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Endocrine
Erschienen in: Endocrine 3/2015

01.12.2015 | Mini Review

The impact of vitamin D deficiency on patients undergoing kidney transplantation: focus on cardiovascular, metabolic, and endocrine outcomes

verfasst von: Gerardo Sarno, Giuseppe Daniele, Giacomo Tirabassi, Alberto O. Chavez, Opeolu O. Ojo, Francesco Orio, Hana Kahleova, Giancarlo Balercia, William B. Grant, Paride De Rosa, Annamaria Colao, Giovanna Muscogiuri

Erschienen in: Endocrine | Ausgabe 3/2015

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Abstract

Vitamin D deficiency is common among kidney transplant (KT) recipients because of reduced sunlight exposure, low intake of vitamin D, the immunosuppressive drug regimen administered, and steroid therapy. Glucocorticoids regulate expression of genes coding for enzymes that catabolize vitamin D, further reducing its level in serum. Although vitamin D primarily regulates calcium homeostasis, vitamin D deficiency is associated with the risk of several diseases, such as diabetes mellitus and tuberculosis. Aim of this review is to highlight endocrine and metabolic alterations due to the vitamin D deficiency by evaluating the mechanisms involved in the development of KT-related disease (cardiovascular, bone mineral density, and new-onset diabetes after transplantation). Next, we review evidence to support a link between low vitamin D status and KT-related diseases. Finally, we briefly highlight strategies for restoring vitamin D status in KT patients.
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Metadaten
Titel
The impact of vitamin D deficiency on patients undergoing kidney transplantation: focus on cardiovascular, metabolic, and endocrine outcomes
verfasst von
Gerardo Sarno
Giuseppe Daniele
Giacomo Tirabassi
Alberto O. Chavez
Opeolu O. Ojo
Francesco Orio
Hana Kahleova
Giancarlo Balercia
William B. Grant
Paride De Rosa
Annamaria Colao
Giovanna Muscogiuri
Publikationsdatum
01.12.2015
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 3/2015
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-015-0632-8

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