29.11.2016 | Original Article
The influence of seasonality and manufacturer kit lot changes on 17α-hydroxyprogesterone measurements and referral rates of congenital adrenal hyperplasia in newborns
Erschienen in: European Journal of Pediatrics | Ausgabe 1/2017
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What is Known:
• Newborn screening for congenital adrenal hyperplasia is generally performed by measuring 17α-hydroxyprogesterone (17-OHP) levels in dried blood spots.
• 17-OHP concentrations are affected by gestational age/weight of infant when specimen is collected, specimen collection time after birth, as well as race and sex of infant.
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What is New:
• Seasonal temperature variations and unanticipated manufacturer kit changes affect 17-OHP levels and consequently referral rates in programs that use fixed cutoffs.
• Daily mean 17-OHP is generally higher when the ambient temperature is lower.
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