nach oben

BMC Complementary Medicine and Therapies

Erschienen in:

Open Access 01.12.2023 | Research

The intention of utilization and experience toward traditional Chinese medicine among breast cancer patients in the early and late stages: a qualitative study

verfasst von: Kai-wei Chen, Kuo-piao Chung, Chung-hua Hsu

Erschienen in: BMC Complementary Medicine and Therapies | Ausgabe 1/2023

Abstract

Background

In Taiwan, breast cancer patients usually take conventional medicine and traditional Chinese medicine simultaneously. The utilization of traditional Chinese medicine among breast cancer patients at various stages has not been examined. This study aims to compare the intention of utilization and experience toward traditional Chinese medicine among early- and late-stage breast cancer patients.

Method

This qualitative research collected data from breast cancer patients through focus groups interview by convenience sampling. Conducted in 2 branches of Taipei City Hospital, a public hospital managed by the Taipei City government. Breast cancer patients > 20 years old and had used TCM for breast cancer therapy for at least 3 months were included in the interview. A semi-structured interview guide was adopted in each focus group interview. In the following data analysis, stages I and II were considered early-stage, and stages III and IV were late-stage. For analyzing the data and reporting the results, we used qualitative content analysis as the approach for data analysis, assisted by NVivo 12. Categories and subcategories were identified through content analysis.

Results

Twelve and seven early- and late-stage breast cancer patients were included in this study, respectively. The side effects were the main intention of utilizing traditional Chinese medicine. Improving side effects and constitution was the main benefit for patients in both stages. Additionally, early-stage breast cancer patients used traditional Chinese medicine to prevent recurrence or metastasis. Late-stage breast cancer patients responded more frequently to the use of traditional Chinese medicine due to the side effects of western medicine. However, some of their symptoms were not fully relieved.

Conclusions

Breast cancer staging may influence the intention and utilization of traditional Chinese medicine. Health policymakers should consider the results of this research and the evidence-based illustrations to establish guidelines for integrating traditional Chinese medicine among various stages of breast cancer to improve the outcome and quality of care for cancer patients.

Additional file 1. Interview guide for BCPs focus groups.

Supplementary Information

The online version contains supplementary material available at https://doi.org/10.1186/s12906-023-04054-0.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

CAM

Complementary and alternative medicine

TCM

Traditional Chinese medicine

BCPs

Patients with breast cancer

Western medicine

Introduction

Cancer is the leading cause of death worldwide, responsible for nearly 10 million deaths in 2020 [1]. In Taiwan, cancer has been the main cause of death for over 40 years [2]. In 2019, the incidence rate of colorectal and breast cancer were the highest among males and females, respectively, in Taiwan [3]. While breast cancer is the second most common cancer among all genders and the most common cancer among women worldwide [4, 5]. The age-standardized incidence rate of breast cancer in more developed regions is higher than in less developed regions [5, 6]. Besides, breast cancer was the second cause of death in developed countries in the world [4, 5]. In 2021, breast cancer is the fourth leading cause of cancer death, with a crude death rate of 24.6 per 100,000 population [7]. Due to the poor quality of life, anxiety, chronic pain, and psychosocial stress, cancer patients might use complementary and alternative medicine (CAM), to improve the symptoms after cancer diagnosis [8]. The prevalence of CAM use in cancer patients worldwide is approximately 40% [9], and the complementary therapies of cancer include Traditional Chinese medicine (TCM), diet supplements, herbal medicines, homeopathy, body-mind therapies, and others [10, 11]. TCM, which include herbal medicine, acupuncture, Qi Gong, Tai Qi, food therapy, Tui Na (Chinese massage) [12, 13], is the type of CAM mostly used in Taiwan [14]. According to the National Center for Complementary and Integrative Health(NCCIH), complementary medicine approaches can be classified as nutritional, psychological, physical, and combinations [15]. And due to TCM cannot fit any of these, it is defined as an “other complementary health approach” [15]. Despite it, TCM is still widely used because of the ancient Chinese culture and because it is an important medical approach in Taiwan [16]. All Taiwanese citizens are mandated to join the National Health Insurance, a single-payer system for healthcare implemented in 1995 [16, 17]. Its coverage rate in recent years is more than 99% [17, 18]. Under the National Health Insurance, Western medicine (WM) and TCM were included in the program [16, 17, 19]. People can choose WM, TCM, or both because of the accessibility and affordability of the healthcare system [16‐19]. Conventional medicine, a system that involves medical doctors and other healthcare professionals to treat symptoms and diseases [20], is usually combined with TCM among cancer patients in Taiwan [21]. Studies have shown that TCM is most commonly used by patients with breast cancer (BCPs) [11]; 81.5% of BCPs will use TCM at least once after diagnosis, and 95.8% of TCM users used WM simultaneously [22]. The most frequently used TCM approaches for BCPs in Taiwan are Chinese herbal medicine (80.5%), followed by acupuncture or traumatology manipulative therapies (22.3%) [23]. However, according to research about the mental health of cancer patients, early- and late-stage patients have different degrees of depressive symptoms[24]. Patients with more advanced cancer stages were more likely to use Chinese medicine after diagnosis [25]. Besides, the effects of TCM care for cancer patients at different stages, including prognosis and survival time, vary [13, 26‐28]. Therefore, because of the various stages of cancer, the intention of TCM utilization and experience may differ. There is a lack of studies exploring the intention of utilization and experience toward TCM among early- and late-stage cancer patients. Breast cancer has a high incidence rate, and BCPs tend to use TCM [3, 7, 11, 23]. This study compares the intention of TCM utilization and the experience of early- and late-stage BCPs.

Method

Design

To explore the intention and experience of early- and late-stage BCPs toward TCM, we adopted a qualitative research method. We collected and analyzed interview data regarding the participants’ perspectives from March to June 2021 by audio recording and analyzed the data after transcribing them verbatim. This study conducted focus group interviews for BCPs to understand the comparison between early- and late-stage breast cancer. In this study, stages I and II were considered early-stage, and stages III and IV were late-stage, based on the definition of the National Breast Cancer Foundation [29] and several studies [30, 31].

Participants and setting

Nineteen BCPs participated in this study. In the focus group interviews, there were 3 to 5 participants in five focus groups, regarded as mini focus groups. With the interviewer’s guidance, the participants can provide more in-depth perspectives in a mini focus group [32]. Patients > 20 years old, diagnosed with breast cancer, and had used TCM for breast cancer therapy for at least 3 months were included in the interview. Before the interview, the interviewer informed the participants of their rights and that they could withdraw from the study anytime for any reason. The code numbers were applied instead of their names to maintain anonymity. The participants who agreed to the study signed an informed consent form. This study was approved by the Research Ethics Committee of Taipei City Hospital (Protocol number TCHIRB-11002011-E).

Data collection

The participants were recruited using electronic and paper posters that were approved by the Research Ethics Committee of Taipei City Hospital. The posters were distributed among cancer patient groups at the hospital, with convenience sampling employed to collect the data. Following the recruitment process, BCPs were interviewed in several focus groups. We used a semi-structured guide with open-ended questions to conduct the interviews. The interview guide included six open-ended questions developed from the literature [33‐35] and revised after discussing with co-authors (See the Additional file 1). The interviews were conducted in the Ren-ai Branch and Linsen Chinese Medicine and Kunming Branch of Taipei City Hospital, a public hospital with 4,700 beds in seven branches managed by the Taipei city government [36]. The data collection process continued until saturation was reached. The interviews were recorded using an audio recorder and subsequently transcribed into traditional Chinese text.

Data analysis

After the interviews, the meaning unit of this study was found by listening to the audio record repeatedly and browsing the transcript verbatim followed by coding in accordance with the study’s objective after carefully understanding the text [37]. The data were analyzed through a conventional content analysis approach, which included driving the original codes after repeatedly reading the text and inducting or deducting them into subcategories, categories, and themes [38‐40]. We applied computer-assisted qualitative data analysis software—Nvivo 12— to assist the organization and classification of data analysis and improve its efficiency [41]. To elevate the rigor of the qualitative study, triangulation, and peer review were conducted in the research. We also collected adequate data and increased the credibility, dependability, confirmability, and transferability through the thick description and maximum variation [41‐43].

Results

Participants’ characteristics

Twenty-one BCPs were recruited for focus group interviews, but two were absent. Therefore, 12 and 7 BCPs in the early and late stages completed the interviews. The age of the participants ranged from 43 to 71 (mean = 55.42 ± 7.11) years. The mean time since cancer diagnosis was 3.92 ± 2.53 years (Table 1). In the following text, the codes starting with ‘E’ or ‘A’ refer to BCPs with early or late stages, respectively.

Table 1

Statistics on the information of breast cancer patients participants

Characteristic	No. (SD)
Mean age	55.42 (± 7.11)
Time since diagnosed (year)	3.92 (± 2.53)
Stage
Early stage
I	7
II	5
Late stage
III	1
IV	6
The class of hospital for TCM consulted
Regional	2
District	17

The intention of TCM utilization for BCPs

BCPs were influenced by their feelings about diagnosis and multiple reasons for attempting TCM. According to data analysis, this theme contains two categories, including the mental state of BCPs after cancer diagnosis and the factors influencing BCPs to use TCM (Table 2).

Table 2

Key codes of the intention of TCM utilization for BCPs

Categories	Subcategories	Codes	Frequency of early-stage BCPs^a	Frequency of late-stage BCPs^a
Mental feelings of BCPs after cancer diagnosis	Negative mental impact	Cannot accept the diagnosis	8	4
		Shocked	9	6
		Sad or tearful	6	3
		Scared or upset	3	3
		Thought she was healthy	3	1
		Thought about the follow-up arrangements	1	3
	Facing it positively	Did not be nervous or worried	7	3
		Did not think it was an illness	2	0
		Soul had sustenance	1	1
		Peaceful coexistence	2	1
		Accepted it and faced it	3	4
		Hoped to live on	1	4
The influence factors of BCPs starting to use TCM	Push force of using TCM	Suffering from side effects	4	10
	Push force of using TCM	Worried about the treatment of WM	1	1
	Pull force of using TCM	Recommendations from family members or friends	11	7
		Hoped to adjust her constitution	7	7
		Trust in TCM	2	2
		Based on personal experience	2	1
		Prevention of recurrence or metastasis	4	0
		WM recommendation	1	0
		Last resort	1	0

^aAmong the BCPs participants, there are 12 in the early stage and 7 in the late stage

Mental state of BCPs after cancer diagnosis

BCPs were shocked after diagnosis. Whether early or late-stage, most BCPs faced negative mental stress after a cancer diagnosis. Some BCPs could not accept the diagnosis and might be depressed, shocked, or upset.

“At that time, it was really very upsetting, I couldn’t accept it, why did I get cancer?” (E1)

Some BCPs faced the diagnosis head-on without nervousness or fear. They accepted it and lived peacefully because they believe cancer is not an illness. They also believe their soul has sustenance and hope to continue surviving.

“My thought was that I could persist in (survive) or something like that, I can persist in till the end.” (A1)

Factors influencing BCPs to use TCM

BCPs started using TCMs for various reasons. Under conventional treatment, BCPs usually suffer physical and psychological side effects, including skin symptoms, hot flashes, constipation, depression, insomnia, and restlessness. Some were also worried about the treatment with WM. While nearly all BCPs were plagued by conventional medical side effects that drove the force of pushing to TCM utilizing. Especially mentioned more frequently in late-stage patients.

“Because of the side effects of the drugs at that time, I would have itching and hives on my body.” (E11)

“I used that TCM for conditioning, and then I adjusted my mentality, … Because of the side effects of chemotherapy, there would be hot flushes and insomnia… that was emotional anxiety.” (A1)

However, BCPs used TCM might also be affected by the force of pulling. In other words, BCPs in any stage used TCM based on the recommendations of family members or friends, individual trust, and personal experience, and believed TCM could help to adjust the patients’ constitution.

“At the beginning of chemotherapy, many friends introduced me to visit the TCM physician and suggested I see him.” (A6)

“I am quite confident in Chinese medicine. …, I was diagnosed in May 2010, …, I have been taking traditional Chinese medicine for conditioning since then.” (E2)

Furthermore, early-stage BCPs believed that tumor recurrence or metastasis could be prevented through TCM utilization.

“I had been worrying about whether the tumor will recur, metastasize, or I will die,… then I went to see the TCM physicians.” (E1)

The experience of BCPs in TCM care

Under TCM care, BCPs experienced some changes. According to data analysis, this comprises two categories: the perceived effects and feelings of TCM and the expectations for TCM care (Table 3).

Table 3

Key codes of the experience of BCPs in TCM care

Categories	Subcategories	Codes	Frequency of early-stage BCPs^a	Frequency of late-stage BCPs^a
Perceive effects and feelings of BCPs from TCM experience	Changes in physiology	Relieving side effects	15	10
		Constitution enhancement	12	3
		Tumor Control and Prevention	4	1
		Improved physiological function	6	2
		Improved the quality of life	1	0
		Reduced the dose of WM	1	0
		Catastrophic illness has been canceled	2	0
	Changes in psychological	Felt peace of mind	9	3
	Changes in psychological	Mood was better	1	0
	Changes to social well-being	Improved family relationships	1	0
	Unmet care needs	Side effects were not fully been improve	1	3
	Communica-tion between TCM and WM	WM agreed with the use of TCM	4	2
		WM rejected TCM use	5	3
		Did not inform WM physicians	3	3
The expectation of BCPs to TCM care	Clinical practices of TCM	Medication Safety and Convenience	5	2
		Establish TCM consultation	5	0
		Long waiting time	3	4
	Policies of TCM	Suggestions for scientific TCM	2	0
		Cooperation between Chinese and Western medicine	1	0
		Suggestions for daycare of cancer	3	8

^aAmong the BCPs participants, there are 12 in the early stage and 7 in the late stage

Perceived effects and feelings of TCM

Early- and late-stage BCPs experienced the physical or psychological perceived effects of TCM.

Early- and late-stage BCPs frequently mentioned that TCM improved the side effects of their conventional medical treatment. They also mentioned the enhancements to their body constitution.

“The biggest improvement for me from TCM is that I used to have diarrhea, … but after taking this Chinese medicine, it became normal.” (E12)

“In addition to fatigue, it was rash, diarrhea, and hand-foot syndrome. I think the acupuncture from daycare of TCM is very helpful for me.” (A2)

Furthermore, after TCM care, BCPs felt more spiritually stable and had improved moods. Early- and late-stage BCPs had similar perspectives.

“After taking the Chinese medicine, it let me sleep better, and then I felt calmer.” (A1)

“I feel that Chinese medicine decoction gives me a very stable strength. …. I believe that if my mental status is healed, then my body should also be fine.” (E4)

However, some BCPs mentioned that their needs for using TCM were not being met. Especially late-stage BCPs frequently mentioned that their side effects were not relieved.

“I think insomnia is actually very difficult to relieve …every time I told the physician: ‘I can’t sleep’, he would change the medicine and strengthen it.” (A7)

For the use of TCM, regardless of early- or late-stage breast cancer, patients communicated with WM practitioners and either got approval or were rejected. Moreover, some BCPs did not inform WM physicians of TCM usage due to fear or feeling that it was meaningless.

“The western physician said, ‘okay, if it helps you, just go to see TCM.” (E11)

“I already trust TCM very much, I don’t need WM to give me affirmation, so I don’t need to ask them.” (E2)

The expectations for TCM care

Most BCPs were satisfied with the current TCM care but had some expectations about TCM. In clinical practice, many BCPs mentioned that the safety and convenience of TCM still need to be strictly verified. The long waiting time and the lack of available TCM consultations should be improved.

“The ingredients of concentrated scientific Chinese medicine is the toxicity of lead. Many people will worry about this problem.” (A1)

“There are really too many patients in the TCM physician…the time to answer my question may be a bit rushed.” (A6)

In terms of policy, BCPs thought TCM should be more scientific and incorporated with WM. The enhanced daycare of TCM for cancer can be implemented more extensively.

“I feel that Chinese medicine is going to develop this kind of instrument that can be digitized…that can help them make a more accurate diagnosis.” (E9)

“I think this enhanced daycare of TCM is only available in our hospital. I think it is too lack, and it really needs to be everywhere.” (E10)

Discussion

To our knowledge, this is the first study to explore the intention and experience of BCPs in the early and late stages toward TCM utilization using content analysis to compare the frequency of specific codes. Through this study, we can further understand the factors that affect BCPs’ demand for TCM care.

BCPs were driven by push and pull by cancer diagnosis and treatment to use TCM

The intention of BCPs to use TCM in this study may be a disturbance to the disease, which becomes a push for the use of TCM; BCPs believed that TCM could benefit cancer referred to as a pull for using TCM.

Previous studies have indicated that patients will generate push factors for TCM use due to dissatisfaction with WM care or generate pull factors based on their background and attraction to the benefits of TCM care, forming a “push-pull model” [34, 44].

This study found that suffering from the side effects of WM treatment is an important push force driving early- and late-stage BCPs to use TCM. Late-stage BCPs especially mentioned this disturbance more frequently and hoped TCM would strengthen their constitution. It is similar to the results of previous studies [22, 45, 46] in that BCPs used TCM to improve the side effects, provide tonic effects, and treat the tumor since late-stage BCPs might experience more side effects after WM treatment, including physical and psychological discomfort. Hamer et al. demonstrated that advanced BCPs had greater symptom burden and lower quality of life than early-stage BCPs [47]. Therefore, late-stage BCPs had more motivation to undergo TCM. In addition, early- and late-stage BCPs use TCM because of the trust and hope that TCM can adjust their body constitution, which is common between both groups. Hence, cancer patients usually trust TCM because of their cultural background and personal experience [35].

However, the factor “hoping to prevent metastasis and recurrence” was only mentioned by early-stage BCPs. It may relate to the results of this study. Late-stage BCPs do not aim to cure or eliminate cancer but hope that TCM can improve their physical strength and reduce side effects so they can coexist peacefully with cancer cells. One literature pointed out that early-stage BCPs experience crucial psychological distress regarding recurrence compared with late-stage BCPs [48].

An early-stage BCP responded that she thought TCM was the last option except for WM, so she tried to receive TCM care. TCM can be regarded as a BCP’s last resort to stay alive, according to Smithson et al. and Yu et al., seeking CAM or TCM is the last resort for cancer patients to control cancer and get better outcomes [33, 49].

TCM is beneficial for breast cancer care, and BCPs in various stages had different care needs for TCM

The most frequent response was that TCM could improve the side effects of the BCPs, whether early- or late-stage, and enhance physical strength so they can continue WM treatment. Most participants only use oral Chinese medicine, including concentrated powder and Chinese medicine decoction. Some participants also receive acupuncture treatment in addition to obtain more intensive TCM care. In participants’ responses, TCM can improve physiological side effects such as diarrhea or constipation, insomnia, skin rash, poor appetite, hot flashes, menopausal syndrome, hand-foot syndrome, and symptoms of numbness in the hands and feet. Especially, participants in enhanced daycare indicated significant improvements not only in relieving gastrointestinal symptoms induced by WM but also in reducing fatigue and enhancing physical strength after TCM intervention. The improvement in quality of life was also significant and believed to be beneficial. On the other hand, TCM can also play a role in enhancing psychological well-being. Almost all participants mentioned feeling calm and experiencing an improved mood after receiving TCM intervention. Many studies have demonstrated that TCM can alleviate the adverse effects of conventional medicine [12, 45, 50‐53], inhibit cancer cells [54, 55], and improve the quality of life or prolong survival time [13, 51, 54‐56].

According to the participants’ responses, TCM has different effects in different periods of WM treatment. Before WM treatment, TCM plays a preventive role. During the WM treatment period, both early- and late-stage BCPs are suffered by the side effects of WM, and TCM can relieve their symptoms and help the treatment continue and complete. After finishing the WM treatment, TCM becomes a supportive and maintenance role, allowing patients to return to their normal lives.

‘Tumor control and prevention’ is one of the positive changes brought about by TCM care, and early-stage patients mentioned it frequently. Compared with late-stage breast cancer, early-stage breast cancer cells are more stable and can be protected from tumor progression through TCM. Some previous studies have reported that one of the reasons why cancer patients use TCM is to prevent tumor recurrence or metastasis [34]. TCM has proven to be effective in preventing cancer recurrence and metastasis [55, 57]. A study showed that the rates of psychosocial distress are high and similar among early- and late-stage BCPs [58], and TCM can improve psychological stability in both groups. The effects on early- and late-stage BCPs during various WM treatment periods had shown in Fig. 1. In particular, one participant mentioned that after TCM care, she could take care of herself, and her family relationship improved. This is like the World Health Organization’s definition of health: ‘health is a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity’ [59]. However, after TCM care, some participants felt that their care needs regarding side effects had not been met, and most were late-stage patients. It is estimated that the treatment methods and doses for late-stage BCPs are more complicated when treated with WM, making the side effects more pronounced, so the need for TCM would also be affected. This response is similar to a previous study [60] indicating that cancer patients in late stages generally undergo chemotherapy and radiotherapy as the preferred treatments after surgery. While the side effects of these therapies, including myelosuppression, gastrointestinal tract reactions, and cardiac damage, can be more complicated. Moreover, tumor cells may develop resistance to conventional treatments, rendering them less effective over time [60]. Therefore, TCM can serve as an adjunctive therapy, making efforts to deal with the side effects and complications caused by chemotherapy and radiotherapy for BCPs in late stages.

TCM is beneficial to BCPs, and some WM practitioners agreed for the use of TCM, especially for early-stage breast cancer. However, many BCPs responded that WM practitioners were less accepting of TCM due to worries about the mutual influence of Chinese and Western medicine. WM consultants of late-stage BCPs were more reluctant to accept TCM, probably because they were more worried about its possible interaction with efficacy. Not all BCPs discussed the use of TCM with WM, probably because of fear of telling or the feeling that reporting it is meaningless. Studies have also shown that many BCPs do not inform WM physicians of the use of CAM or TCM, and most of their WM physicians were unaware that the patients were using other therapies [61, 62]. Therefore, the risk of potential interaction between Chinese and Western medicines may be increased, causing unexpected adverse reactions [22, 63].

Some participants believe that WM and TCM should be integrated to establish communication and cooperation. Many studies have shown that proper integration of Chinese and Western medicine in cancer care can improve the survival rate, quality of life, and overall health of cancer patients [13, 22, 64‐66]. Wang and his colleagues [65] conducted a meta-analysis study on 29 randomized controlled trials studies that included 3,142 BCPs. The study found that compared to conventional treatments alone, the combination of TCM and conventional treatments can improve short-term treatment efficacy and have a better 3-year and 5-year survival rate after mastectomy. It can also reduce the incidence of adverse reactions, including nausea and vomiting, leucopenia, thrombocytopenia, and upper extremity edema. Another meta-analysis study that included 22 randomized controlled trial studies with a total of 1,689 BCPs also confirmed that the combination of TCM interventions such as Chinese herbal medicine and acupuncture with conventional treatments can improve the quality of life, alleviate side effect symptoms, and improve the value of tumor markers, compared to those who use conventional chemotherapy, radiation therapy, and endocrine therapy alone [66]. In this study, participants believed that if TCM clinics had more time for consultations, TCM could be practiced in a more scientific manner and the quality of TCM treatments could be improved, resulting in safer care and better quality of life for cancer patients. Regarding the waiting time that some BCPs expect, due to the coverage of TCM by the National Health Insurance in Taiwan, Approximately 5.5 million individuals sought TCM outpatient care in 2021, resulting in an average of 6.24 visits per user [67, 68]. Notably, cancer patients specifically chose TCM care based on their reputation [35]. Consequently, this heightened demand can potentially lead to prolonged waiting periods at certain TCM clinics. As stated in the literature, scientific evidence-based research on TCM should be strengthened [46, 53, 56], and the heterogeneity of Chinese medicine quality should improve [53], since the enhanced daycare of TCM for cancer is also beneficial to the alleviation of adverse reactions for cancer patients [69].

Limitations

The BCPs focus group interviews in this study included 19 participants, 12 early-stage and 7 late-stage patients. Although great efforts were made for recruitment, the numbers of early- and late-stage BCPs were unequal. The late-stage BCPs were fewer, similar to the breast cancer survival statistics, and this study tried to encourage participants to fully express their opinions during the interviews. This study recruited BCP participants by convenience sampling, which may introduce a selection bias. While the viewpoints were completely collected in the research until it was saturated, future research should extend the sampling source to avoid possible bias.

According to the study’s purpose, we only included those who had experience using TCM; we did not explore the views of non-users. Therefore, the reasons why those BCPs did not use TCM care are unknown. We only explored participants’ utilization and experiences of TCM in the healthcare system and did not discuss the types and frequency of TCM used by participants. Future research may be needed to further explore the above.

Conclusion

Relieving the side effects of conventional treatment and trust in TCM are the main factors for BCPs to use TCM. Many BCPs experienced relief from side effects, improved constitution, and emotional stability with TCM. Early-stage BCPs additionally expected that TCMs could prevent cancer from recurrence and metastasis. Late-stage BCPs frequently indicated that the need for care was not fulfilled. Early- and late-stage BCPs’ intentions and experiences in TCM utilization were inconsistent. Scientific evidence-based research on TCM and integration with WM to improve the quality of cancer care should be strengthened. Based on the results of the studies, health policymakers can appropriately revise cancer TCM care programs or care guides with WM to meet the treatment needs of various stages to improve the quality of care and outcome in cancer care.

Acknowledgements

We want to express our gratitude to all the participants in this study. And we thank the Kuan Sin association and all partners in the 635 Research room to assist with the research conducting.

Declarations

This study was approved by the Research Ethics Committee of Taipei City Hospital (Protocol number TCHIRB-11002011-E). The participants who agreed to the study signed an informed consent form. All methods were performed in accordance with the relevant guidelines and regulations.

Consent to publication was obtained from each participant.

Competing interests

The authors declare no competing interests.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Additional file 1. Interview guide for BCPs focus groups.

International Agency for Research on Cancer. The Global Cancer Observatory: Cancer Today. 2020. https://gco.iarc.fr/today/data/factsheets/cancers/39-All-cancers-fact-sheet.pdf. Accessed 21 Jan 2023.

Ministry of Health and Welfare. Cause of death statistics over the years. 2022. https://dep.mohw.gov.tw/DOS/cp-5069-71092-113.html. Accessed 10 Jan 2023.

Health Promotion Administration. Top 10 cancer incidence rates. 2022. https://www.gender.ey.gov.tw/gecdb/Stat_Statistics_DetailData.aspx?sn=nLF9GdMD%2B%2Bv41SsobdVgKw%3D%3D. Accessed 3 Jan 2023.

Ferley J, Soerjomataram I, Ervik M. Cancer incidence and mortality worldwide: IARC CancerBase No. 2013.

Momenimovahed Z, Salehiniya H. Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer Targets Ther. 2019;11:151–64. https://doi.org/10.2147/BCTT.S176070.CrossRef

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA-Cancer J Clin. 2015;65(2):87–108. https://doi.org/10.3322/caac.21262.CrossRefPubMed

Ministry of Health and Welfare. Cancer causes of death. 2022. https://dep.mohw.gov.tw/DOS/cp-5069-71092-113.html. Accessed 10 Jan 2023.

Jurisevic M, Bolevich S. Complementary and alternative medicine applications in cancer medicine. Tradit Med Res. 2020;5(1):7–21. https://doi.org/10.12032/Tmr20190728127.CrossRef

Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M. How many cancer patients use complementary and alternative medicine: a systematic review and metaanalysis. Integr Cancer Ther. 2011;11(3):187–203. https://doi.org/10.1177/1534735411423920.CrossRefPubMed

10.

Rossi E, Di Stefano M, Firenzuoli F, Monechi MV, Baccetti S. Add-on complementary medicine in cancer care: evidence in literature and experiences of integration. Medicines. 2017;4(1):5. https://www.mdpi.com/2305-6320/4/1/5.CrossRefPubMedPubMedCentral

11.

Kuo YT, Chang TT, Muo CH, et al. Use of complementary traditional Chinese medicines by adult cancer patients in Taiwan: a nationwide population-based study. Integr Cancer Ther. 2018;17(2):531–41. https://doi.org/10.1177/1534735417716302.CrossRefPubMed

12.

McQuade JL, Meng Z, Chen Z, et al. Utilization of and attitudes towards traditional Chinese medicine therapies in a Chinese cancer hospital: a survey of patients and physicians. Evid Based Complement Alternat Med. 2012;2012:504507. https://doi.org/10.1155/2012/504507.CrossRefPubMedPubMedCentral

13.

Lee YC, Chen YH, Huang YC, Lee YF, Tsai MY. Effectiveness of combined treatment with traditional Chinese medicine and western medicine on the prognosis of patients with breast cancer. J Altern Complement Med. 2020;26(9):833–40. https://doi.org/10.1089/acm.2019.0200.CrossRefPubMed

14.

Chang MY, Liu CY, Chu MC, Wu TM, Chen ML, Chu ML. Conditions for the use of complementary and alternative medicine in Taiwan: a nationwide survey analysis for 2011. Taiwan J Public Health. 2013;32(1):85–99. https://doi.org/10.6288/TJPH2013-32-01-11.CrossRef

15.

National Center for Complementary and Integrative Health (NCCIH). Complementary, alternative, or integrative health: what’s in a name? 2021. https://www.nccih.nih.gov/health/complementary-alternative-or-integrative-health-whats-in-a-name. Accessed 12 Jan 2023.

16.

Yeh YH, Chou YJ, Huang N, Pu C, Chou P. The trends of utilization in traditional Chinese medicine in Taiwan from 2000 to 2010: a population-based study. Medicine (Baltimore). 2016;95(27):e4115. https://doi.org/10.1097/MD.0000000000004115.CrossRefPubMed

17.

Wu TY, Majeed A, Kuo KN. An overview of the healthcare system in Taiwan. London J Prim Care (Abingdon). 2010;3(2):115–9. https://doi.org/10.1080/17571472.2010.11493315.CrossRefPubMed

18.

Lin LY, Warren-Gash C, Smeeth L, Chen PC. Data resource profile: the National Health Insurance Research Database (NHIRD). Epidemiol Health. 2018;40:e2018062. https://doi.org/10.4178/epih.e2018062.CrossRefPubMedPubMedCentral

19.

Chen PH, Huang SM, Lai JC, Lin WL. Determinants of health-seeking behavior toward Chinese or Western medicine in Taiwan: an analysis of biobank research database. Complement Ther Clin Pract. 2022;48:101592. https://doi.org/10.1016/j.ctcp.2022.101592.CrossRefPubMed

20.

National Cancer Institute. Conventional medicine. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/conventional-medicine. Accessed 10 May 2023.

21.

Pu CY, Lan VM, Lan CF, Lang HC. The determinants of traditional Chinese medicine and acupuncture utilization for cancer patients with simultaneous conventional treatment. Eur J Cancer Care (Engl). 2008;17(4):340–9. https://doi.org/10.1111/j.1365-2354.2007.00865.x.CrossRefPubMed

22.

Lai JN, Wu CT, Wang JD. Prescription pattern of chinese herbal products for breast cancer in Taiwan: a population-based study. Evid Based Complement Alternat Med. 2012;2012:891893. https://doi.org/10.1155/2012/891893.CrossRefPubMedPubMedCentral

23.

Lin YH, Chiu JH. Use of Chinese medicine by women with breast cancer: a nationwide cross-sectional study in Taiwan. Complement Ther Med. 2011;19(3):137–43. https://doi.org/10.1016/j.ctim.2011.04.001.CrossRefPubMed

24.

Vodermaier A, Linden W, MacKenzie R, Greig D, Marshall C. Disease stage predicts post-diagnosis anxiety and depression only in some types of cancer. Br J Cancer. 2011;105(12):1814–7. https://doi.org/10.1038/bjc.2011.503.CrossRefPubMedPubMedCentral

25.

Liu TG, Xiong SQ, Yan Y, Zhu H, Yi C. Use of Chinese herb medicine in cancer patients: a survey in southwestern china. Evid Based Complement Alternat Med. 2012;2012:769042. https://doi.org/10.1155/2012/769042.CrossRefPubMedPubMedCentral

26.

Lee YW, Chen TL, Shih YR, et al. Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: a population-based study. Cancer. 2014;120(9):1338–44. https://doi.org/10.1002/cncr.28579.CrossRefPubMed

27.

McCulloch M, Broffman M, van der Laan M, et al. Colon cancer survival with herbal medicine and vitamins combined with standard therapy in a whole-systems approach: ten-year follow-up data analyzed with marginal structural models and propensity score methods. Integr Cancer Ther. 2011;10(3):240–59. https://doi.org/10.1177/1534735411406539.CrossRefPubMed

28.

Shi Q, Liu S, Li W, et al. Exploring the medication duration based on the effect of traditional Chinese medicine on postoperative stage I-III colorectal patients: a retrospective cohort study. Oncotarget. 2017;8(8):13488–95. https://doi.org/10.18632/oncotarget.14567.CrossRefPubMedPubMedCentral

29.

National Breast Cancer Foundation. Stages & types of breast cancer. 2023. https://nbcf.org.au/about-breast-cancer/diagnosis/stages-of-breast-cancer/. Accessed 6 Feb 2023.

30.

Lohrisch C, Paltiel C, Gelmon K, et al. Impact on survival of time from definitive surgery to initiation of adjuvant chemotherapy for early-stage breast cancer. J Clin Oncol. 2006;24(30):4888–94. https://doi.org/10.1200/JCO.2005.01.6089.CrossRefPubMed

31.

Unger-Saldana K, Miranda A, Zarco-Espinosa G, Mainero-Ratchelous F, Bargallo-Rocha E, Miguel L-L. Health system delay and its effect on clinical stage of breast cancer: multicenter study. Cancer. 2015;121(13):2198–206. https://doi.org/10.1002/cncr.29331.CrossRefPubMed

32.

O. Nyumba T, Wilson K, Derrick CJ, Mukherjee N. The use of focus group discussion methodology: insights from two decades of application in conservation. Methods Ecol Evol. 2018;9(1):20–32. https://doi.org/10.1111/2041-210X.12860.CrossRef

33.

Yu H, Wang S, Liu J, Lewith G. Why do cancer patients use Chinese medicine?—a qualitative interview study in China. Eur J Integr Med. 2012;4(2):e197–203. https://doi.org/10.1016/j.eujim.2012.02.007.CrossRef

34.

Wang JW, Yang ZQ, Liu C, et al. Cancer survivors’ perspectives and experience on western medicine and traditional Chinese medicine treatment and rehabilitation: a qualitative study. Patient Prefer Adherence. 2015;9:9–16. https://doi.org/10.2147/PPA.S76617.CrossRefPubMed

35.

Liu CH, Tang WR, Wang HM, Lee KC. How cancer patients build trust in traditional Chinese medicine. Eur J Integr Med. 2013;5(6):495–500. https://doi.org/10.1016/j.eujim.2013.08.003.CrossRef

36.

Lee YL, Chu D, Chou SY, Hu HY, Huang SJ, Yen YF. Dental care and infection-control procedures during the COVID-19 pandemic: the experience in Taipei City Hospital, Taiwan. J Dent Sci. 2020;15(3):369–72. https://doi.org/10.1016/j.jds.2020.05.011.CrossRefPubMedPubMedCentral

37.

Vaismoradi M, Turunen H, Bondas T. Content analysis and thematic analysis: implications for conducting a qualitative descriptive study. Nurs Health Sci. 2013;15(3):398–405. https://doi.org/10.1111/nhs.12048.CrossRefPubMed

38.

Hsieh HF, Shannon SE. Three approaches to qualitative content analysis. Qual Health Res. 2005;15(9):1277–88. https://doi.org/10.1177/1049732305276687.CrossRefPubMed

39.

Gale NK, Heath G, Cameron E, Rashid S, Redwood S. Using the framework method for the analysis of qualitative data in multi-disciplinary health research. BMC Med Res Methodol. 2013;13(1):117. https://doi.org/10.1186/1471-2288-13-117.CrossRefPubMedPubMedCentral

40.

Lindgren BM, Lundman B, Graneheim UH. Abstraction and interpretation during the qualitative content analysis process. Int J Nurs Stud. 2020;108:103632. https://doi.org/10.1016/j.ijnurstu.2020.103632.CrossRefPubMed

41.

Merriam SB, Tisdell EJ. Qualitative research: a guide to design and implementation. 4th ed. San Francisco: Jossey-Bass; 2015.

42.

Lincoln YS, Guba EG. Naturalistic inquiry. Beverly Hills: Sage Publications; 1985.CrossRef

43.

Speziale HS, Carpenter DR. Qualitative research in nursing: advancing the humanistic imperative. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2011.

44.

Kelner M, Wellman B. Health care and consumer choice: medical and alternative therapies. Soc Sci Med. 1997;45(2):203–12. https://doi.org/10.1016/s0277-9536(96)00334-6.CrossRefPubMed

45.

Chung VC, Ma PH, Lau CH, Wong SY, Yeoh EK, Griffiths SM. Views on traditional Chinese medicine amongst Chinese population: a systematic review of qualitative and quantitative studies. Health Expect. 2014;17(5):622–36. https://doi.org/10.1111/j.1369-7625.2012.00794.x.CrossRefPubMed

46.

Xu W, Towers AD, Li P, Collet JP. Traditional Chinese medicine in cancer care: perspectives and experiences of patients and professionals in China. Eur J Cancer Care (Engl). 2006;15(4):397–403. https://doi.org/10.1111/j.1365-2354.2006.00685.x.CrossRefPubMed

47.

Hamer J, McDonald R, Zhang L, et al. Quality of life (QOL) and symptom burden (SB) in patients with breast cancer. Support Care Cancer. 2017;25(2):409–19. https://doi.org/10.1007/s00520-016-3417-6.CrossRefPubMed

48.

Reich M, Lesur A, Perdrizet-Chevallier C. Depression, quality of life and breast cancer: a review of the literature. Breast Cancer Res Treat. 2008;110(1):9–17. https://doi.org/10.1007/s10549-007-9706-5.CrossRefPubMed

49.

Smithson J, Britten N, Paterson C, Lewith G, Evans M. The experience of using complementary therapies after a diagnosis of cancer: a qualitative synthesis. Health (London). 2012;16(1):19–39. https://doi.org/10.1177/1363459310371081.CrossRefPubMed

50.

Cohen AJ, Menter A, Hale L. Acupuncture: role in comprehensive cancer care–a primer for the oncologist and review of the literature. Integr Cancer Ther. 2005;4(2):131–43. https://doi.org/10.1177/1534735405276419.CrossRefPubMed

51.

Li X, Yang G, Li X, et al. Traditional Chinese medicine in cancer care: a review of controlled clinical studies published in Chinese. PLoS One. 2013;8(4):e60338. https://doi.org/10.1371/journal.pone.0060338.CrossRefPubMedPubMedCentral

52.

Xiang YN, Cuo ZM, Zhu PF, Chen J, Huang YY. Traditional Chinese medicine as a cancer treatment: modern perspectives of ancient but advanced science. Cancer Med. 2019;8(5):1958–75. https://doi.org/10.1002/cam4.2108.CrossRefPubMedPubMedCentral

53.

Zhang X, Qiu H, Li C, Cai P, Qi F. The positive role of traditional Chinese medicine as an adjunctive therapy for cancer. Biosci Trends. 2021;15(5):283–98. https://doi.org/10.5582/bst.2021.01318.CrossRefPubMed

54.

Nie J, Zhao C, Deng LI, et al. Efficacy of traditional Chinese medicine in treating cancer. Biomed Rep. 2016;4(1):3–14. https://doi.org/10.3892/br.2015.537.CrossRefPubMed

55.

Ye L, Jia Y, Ji KE, et al. Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis. Oncol Lett. 2015;10(3):1240–50. https://doi.org/10.3892/ol.2015.3459.CrossRefPubMedPubMedCentral

56.

Liu J, Wang S, Zhang Y, Fan HT, Lin HS. Traditional Chinese medicine and cancer: history, present situation, and development. Thorac Cancer. 2015;6(5):561–9. https://doi.org/10.1111/1759-7714.12270.CrossRefPubMedPubMedCentral

57.

Wang Y, Li JW, Qin YN, et al. Clinical observation on the effect of Chinese medicine-“TCM formula” intervention on recurrence and metastasis of triple negative breast cancer. Complement Ther Med. 2020;52:102456. https://doi.org/10.1016/j.ctim.2020.102456.CrossRefPubMed

58.

Kissane DW, Grabsch B, Love A, Clarke DM, Bloch S, Smith GC. Psychiatric disorder in women with early stage and advanced breast cancer: a comparative analysis. Aust N Z J Psychiatry. 2004;38(5):320–6. https://doi.org/10.1080/j.1440-1614.2004.01358.x.CrossRefPubMed

59.

World Health Organization. Basic Documents: forty-ninth edition (including amendments adopted up to 31 May 2019). In: Geneva, ed.. Geneva: World Health Organization; 2020. p. 1.

60.

Qi F, Zhao L, Zhou A, et al. The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer. Biosci Trends. 2015;9(1):16–34. https://doi.org/10.5582/bst.2015.01019.CrossRefPubMed

61.

Chin CY, Chen YH, Wu SC, Liu CT, Lee YF, Tsai MY. Complementary and alternative medicine use in breast cancer patients at a medical center in Taiwan: a cross-sectional study. Integr Cancer Ther. 2020;19:1534735420983910. https://doi.org/10.1177/1534735420983910.CrossRefPubMedPubMedCentral

62.

Akeeb AA, King SM, Olaku O, White JD. Communication between cancer patients and physicians about complementary and alternative medicine: a systematic review. J Integr Complement Med. 2023;29(2):80–98. https://doi.org/10.1089/jicm.2022.0516.CrossRefPubMed

63.

Chen KC, Lu R, Iqbal U, et al. Interactions between traditional Chinese medicine and western drugs in Taiwan: a population-based study. Comput Methods Programs Biomed. 2015;122(3):462–70. https://doi.org/10.1016/j.cmpb.2015.09.006.CrossRefPubMed

64.

Tang WR, Yang SH, Yu CT, et al. Long-term effectiveness of combined treatment with traditional Chinese medicine and western medicine on the prognosis of patients with lung cancer. J Altern Complement Med. 2016;22(3):212–22. https://doi.org/10.1089/acm.2015.0214.CrossRefPubMedPubMedCentral

65.

Wang W, Xu L, Shen C. Effects of traditional Chinese medicine in treatment of breast cancer patients after mastectomy: a meta-analysis. Cell Biochem Biophys. 2015;71(3):1299–306. https://doi.org/10.1007/s12013-014-0348-z.CrossRefPubMed

66.

Bai X, Ta N, Gong GH, Zhang B, Wei CX. Effects of integrated Chinese traditional medicine and conventional western medicine on the quality of life of breast cancer patients: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2022;2022:3123878. https://doi.org/10.1155/2022/3123878.CrossRefPubMedPubMedCentral

67.

National Health Insurance Administration. Outpatient and inpatient medical benefit claims. 2021. https://www.nhi.gov.tw/Content_List.aspx?n=6C389A6FCCC5CF4A&topn=23C660CAACAA159D. Accessed 16 May 2023.

68.

National Health Insurance Administration. Statistical quarterly report on total professional medical service quality indicators for traditional Chinese medicine in the 4th quarter of 2022. 2022. https://www.nhi.gov.tw/Content_List.aspx?n=FE0B1F89197DF9F0&topn=23C660CAACAA159D. Accessed 21 May 2023.

69.

Wu HA, Chen CH, Hsieh MH, et al. The benefit of enhanced daycare of traditional Chinese medicine for cancer treatment related adverse events: a retrospective study of medical records. Integr Cancer Ther. 2021;20. https://doi.org/10.1177/15347354211025634.

Titel: The intention of utilization and experience toward traditional Chinese medicine among breast cancer patients in the early and late stages: a qualitative study
verfasst von: Kai-wei Chen
Kuo-piao Chung
Chung-hua Hsu
Publikationsdatum: 01.12.2023
Verlag: BioMed Central
Erschienen in: BMC Complementary Medicine and Therapies / Ausgabe 1/2023
Elektronische ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-023-04054-0

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

The intention of utilization and experience toward traditional Chinese medicine among breast cancer patients in the early and late stages: a qualitative study

Abstract

Background

Method

Results

Conclusions

Supplementary Information

Publisher’s Note

Introduction

Method

Design

Participants and setting

Data collection

Data analysis

Results

Participants’ characteristics

The intention of TCM utilization for BCPs

Mental state of BCPs after cancer diagnosis

Factors influencing BCPs to use TCM

The experience of BCPs in TCM care

Perceived effects and feelings of TCM

The expectations for TCM care

Discussion

BCPs were driven by push and pull by cancer diagnosis and treatment to use TCM

TCM is beneficial for breast cancer care, and BCPs in various stages had different care needs for TCM

Limitations

Conclusion

Acknowledgements

Declarations

Competing interests

Publisher’s Note

Supplementary Information

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Background

Method

Results

Conclusions

Supplementary Information

Publisher’s Note

Introduction

Method

Design

Participants and setting

Data collection

Data analysis

Results

Participants’ characteristics

The intention of TCM utilization for BCPs

Mental state of BCPs after cancer diagnosis

Factors influencing BCPs to use TCM

The experience of BCPs in TCM care

Perceived effects and feelings of TCM

The expectations for TCM care

Discussion

BCPs were driven by push and pull by cancer diagnosis and treatment to use TCM

TCM is beneficial for breast cancer care, and BCPs in various stages had different care needs for TCM

Limitations

Conclusion

Acknowledgements

Declarations

Ethics approval and consent to participate

Consent for publication

Competing interests

Publisher’s Note

Supplementary Information

Weitere Artikel der Ausgabe 1/2023

Defining the landscape of patient harm after osteopathic manipulative treatment: synthesis of an adverse event model

Murine sterile fecal filtrate is a potent pharmacological agent that exerts age-independent immunomodulatory effects in RAW264.7 macrophages

Effectiveness of visceral fascial therapy targeting visceral dysfunctions outcome: systematic review of randomized controlled trials

Enhanced anti-inflammatory and ulcerogenicity of Ibuprofen microsphere formulations using Irvingia wombolu fat (IRW) and moringa oil (MO) as co-lipids

Screening of key functional components of Taohong Siwu Decoction on ischemic stroke treatment based on multiobjective optimization approach and experimental validation

2-phenylacetamide Separated from the seed of Lepidium apetalum Willd. inhibited renal fibrosis via MAPK pathway mediated RAAS and oxidative stress in SHR Rats