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01.07.2015 | Original Research

The Interaction of Voluntary Running Exercise and Food Restriction Induces Low Bone Strength and Low Bone Mineral Density in Young Female Rats

verfasst von: Yuki Aikawa, Umon Agata, Yuya Kakutani, Michito Higano, Satoshi Hattori, Hitomi Ogata, Ikuko Ezawa, Naomi Omi

Erschienen in: Calcified Tissue International | Ausgabe 1/2015

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Abstract

There is a concern that the combination of exercise with food intake reduction has a risk of reducing bone strength and bone mass in young female athletes. We examined the influence of the interaction of voluntary running exercise and food restriction on bone in young female rats. Seven-week-old female Sprague–Dawley rats were divided into four groups: the sedentary and ad libitum feeding group (SED), voluntary running exercise and ad libitum feeding group (EX), sedentary and 30 % food restriction group (SED-FR), and voluntary running exercise and 30 % food restriction group (EX-FR). The experiment lasted 12 weeks. Statistical analysis was carried out by two-way analysis of variance with exercise and restriction as the between-subjects factors. As a result, there were significant interactions of running and restriction on energy availability, breaking force, breaking energy, and bone mineral density (BMD). Breaking force and energy in the EX group were significantly higher than in the SED group; breaking force and energy were significantly lower in the EX-FR group than in the EX group, and breaking force in the EX-FR group was significantly lower than that in the SED-FR group. BMD in the EX-FR group was significantly lower than in the EX and SED-FR groups. These results suggest that food restriction induced low bone strength in young female rats engaging in voluntary running exercise. Also, through the interaction of exercise and food restriction, voluntary running exercise combined food restriction, unlike ad libitum feeding conditions, induced low bone strength, and low BMD in young female rats.

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Titel: The Interaction of Voluntary Running Exercise and Food Restriction Induces Low Bone Strength and Low Bone Mineral Density in Young Female Rats
verfasst von: Yuki Aikawa
Umon Agata
Yuya Kakutani
Michito Higano
Satoshi Hattori
Hitomi Ogata
Ikuko Ezawa
Naomi Omi
Publikationsdatum: 01.07.2015
Verlag: Springer US
Erschienen in: Calcified Tissue International / Ausgabe 1/2015
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-015-0005-6

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