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Current Diabetes Reports

Erschienen in:

01.05.2019 | Microvascular Complications—Nephropathy (M Afkarian and B Roshanravan, Section Editors)

The Interconnection Between Immuno-Metabolism, Diabetes, and CKD

verfasst von: Fabrizia Bonacina, Andrea Baragetti, Alberico Luigi Catapano, Giuseppe Danilo Norata

Erschienen in: Current Diabetes Reports | Ausgabe 5/2019

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Abstract

Purpose of Review

Metabolic reprogramming is increasingly recognized as an essential trait of functional activation of immune cells. Here, we describe the link between immuno-metabolism, diabetes, and diabetic nephropathy.

Recent Findings

Crosstalk between cellular metabolic functions and immune activation occurs when plasma levels of glucose, triglycerides, and free fatty acids increase, thus promoting systemic low-grade inflammation that further boosts the development of metabolic complications. In the long run, this settles an “apparent paradox,” where, despite excessive inflammation, the immune system is suppressed, further promoting progression to end-stage renal disease (ESRD) and predisposing to premature deaths from infections and cardiovascular diseases. Reviewing the effects of diabetes treatments on immuno-inflammatory responses suggests that the benefit of these drugs might extend beyond the simple control of glucose homeostasis.

Summary

Hyperglycemia and dyslipidemia correlate with enhancement of the immuno-inflammatory response that can promote and worsen metabolic diseases and support the progression toward ESRD. The identification of cellular checkpoints that modulate the immuno-metabolic machinery of immune cells opens new venues for metabolic drugs.

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Titel: The Interconnection Between Immuno-Metabolism, Diabetes, and CKD
verfasst von: Fabrizia Bonacina
Andrea Baragetti
Alberico Luigi Catapano
Giuseppe Danilo Norata
Publikationsdatum: 01.05.2019
Verlag: Springer US
Erschienen in: Current Diabetes Reports / Ausgabe 5/2019
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-019-1143-4

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Abstract

Purpose of Review

Recent Findings

Summary

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