nach oben

Metabolic Brain Disease

Erschienen in:

30.03.2017 | Review Article

The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone

verfasst von: Shima Motamedi, Isaac Karimi, Fariba Jafari

Erschienen in: Metabolic Brain Disease | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

The brain-derived neurotrophic factor (BDNF) is involved in metabolic syndrome (MetS) and neurodegenerative diseases (NDD) like Alzheimer's disease, Huntington's disease, Parkinson's disease and depression. If one factor plays an essential role in the pathogenesis of two diseases, it can be concluded that there might be a common root in these two diseases, as well. This review was aimed to highlight the crucial roles of BDNF in the pathogenesis of MetS and NDD and to introduce sole prophylactic or therapeutic applications, BDNF gene therapy and BDFN administration, in controlling MetS and NDD.

Abdel-Maksoud SM, Hassanein SI, Gohar NA, Attia SMM, Gad MZ (2016) Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: modulation by omega-3 fatty acids. Nutr Neurosci 1:1–6CrossRef

Altieri PI, Marcial J, Banchs HL, Escobales N, Crespo M (2015) The metabolic syndrome in Hispanics–the role of inflammation. Glob J Obes Diabetes Metab Syndr 2:12–17CrossRef

Ansari S, Djalali M, Mohammadzadeh N, Mohammadzadeh Honarvar N, Mazaherioun M, Zarei M, Gholampour Z, Javanbakht MH (2016) Assessing the effect of omega-3 fatty acids supplementation on serum BDNF (brain derived neurotrophic factor) in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Int Res J Appl Basic Sci 10:380–383

Astrup A, Finer N (2000) Redefining type 2 diabetes: 'diabesity' or 'obesity dependent diabetes mellitus'? Obes Rev1:57–59

Baptista T, Sandia I, Fernandez E, Balza’n L, Connell L, Tegui EU, Serrano A, Pabo’n A, Angeles FL, Araque Y, Delgado H, Gonza’lez A, Alviarez Y, Pinero J, Baptista EAD (2015) Metabolic syndrome and related variables, insulin resistance, leptin levels, and PPAR-c2 and leptin gene polymorphisms in a pedigree of subjects with bipolar disorder. Rev Bras Psiquiatr 37:106–112CrossRefPubMed

Bauer F, Elbers CC, Adan RAH, Loos RJF, Onland-Moret NC, Grobbee DE, Vliet-Ostaptchouk JVV, Wijmenga C, Schouw YTVD (2009) Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr 90:951–959CrossRefPubMed

Bonaccorso S, Sodhi MLJ, Bobo WV, Chen Y, Tumuklu, M, Theleritis C, Jayathilake K, Meltzer H. Y (2015) The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia. Bipolar Disord 17:528–535

Boyuk B, Degirmencioglu S, Atalay H, Guzel S, Acar A, Celebi A, Ekizoglu I, Simsek C (2014) Relationship between levels of brain-derived neurotrophic factor and metabolic parameters in patients with type 2 diabetes mellitus. J Diabetes Res 143:1–6CrossRef

Brett ZH, Sheridan M, Humphreys K, Smyke A, Gleason MM, Fox N, Zeanah C, Nelson C, Drury S (2015) A neurogenetics approach to defining differential susceptibility to institutional care. Int J Behav Dev 39:150–160CrossRefPubMedPubMedCentral

Brito GN (2009) Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective. Diabetol Metab Syndr 1:7CrossRefPubMedPubMedCentral

Budni J, Bellettini-Santos T, Mina F, Lima Garcez M, Ioppi Zugno A (2016) The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease. Aging Dis 6:331–341CrossRef

Bullo M, Peeraully MR, Trayhurn P, Folch J, Salvado JS (2007) Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women. Eur J Endocrinol 157:303–310CrossRefPubMed

Burns B, Schmidt K, Williams SR, Kim S, Girirajan S, Elsea SH (2010) Rail haploinsufficiency causes reduced BDNF expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with noevidence of metabolic syndrome. Hum Mol Genet 19:4026–4042CrossRefPubMed

Carmona-Mora P, Walz K (2010) Retinoic acid induced 1, RAI1: a dosage sensitive Gene related to neurobehavioral alterations including autistic behavior. Curr Genomics 11:607–617CrossRefPubMedPubMedCentral

Chaldakov GN (2011) The metabotrophic NGF and BDNF: an emerging concept. Arch Ital bio l149:257-263

Chaldakov GN, Tonchev AB, Aloe L (2009) NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines. Rivista Di Psichiatria 44:79–87PubMed

Chaldakov GN, Fiore M, Ranćić G, Beltowski J, Tunçel N, Aloe L (2014) An integrated view: neuroadipocrinology of diabesity. Ser J Expclin Res 15:61–69

Cohen-Cory S, Kidane AH, Shirkey NJ, Marshak S (2010) Brain-derived neurotrophic factor and the development of structural neuronal connectivity. Dev Neurobiol 70:271–288PubMedPubMedCentral

Cools R, Nakamura K, Daw ND (2011) Serotonin and dopamine: unifying affective, activational, and decision functions. Neuropsychopharmacol Rev 36:98–113CrossRef

Duan W, Guo Z, Jiang H, Ware M, Mattson MP (2003) Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. Endocrinol 144:2446–2453CrossRef

Dušátková L, Zamrazilová H, Sedláčková B, Včelák J, Hlavatý P, Hainerová IA, KoRenková V, Bradnová O, Bendlová B, Kunešová M, Hainer V (2013) Association of Obesity Susceptibility Gene Variants with metabolic syndrome and related traits in 1,443 Czech adolescents. Folia Biol (Praha) 59:123–133

Feijó FDM, Bertoluci MC, Reis C (2011) Serotonin and hypothalamic control of hunger: a review. Rev Assoc Med Bras 57:74–77

Ferguson D, Koo JW, Feng J, Heller E, Rabkin J, Heshmati M, Renthal W, Neve R, Liu X, Shao N, Sartorelli V, Shen L, Nestler EJ (2013) Essential role of SIRT1 signaling in the nucleus Accumbens in cocaine and morphine action. J Neurosci 33:16088–16098CrossRefPubMedPubMedCentral

Franco-Robles E, Campos-Cervantes A, Murillo-Ortiz BO, Segovia J, López-Briones S, Vergara P, Pérez-Vazquez V, Solis-Ortiz MS, Ramirez-Emiliano J (2014) Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes. Appl Physiol Nutrmet 39:211–218CrossRef

Gholamine B, Karimi I, Salimi A, Mazdarani P, Becker L (2016) Neurobehavioral toxicity of carbon nanotubes in mice. Focus on brain-derived neurotrophic factor messenger RNA and protein Toxicol Ind Health, doi:10.1177/0748233716644381.

Giannella-Neto D, Gomes MDB (2009) Diabetology and metabolic syndrome: providing an open access future for diabetes research. Diabetol Metab Syndr 1:1CrossRefPubMedPubMedCentral

Guibinga GH, Barron N, Pandori W (2014) Striatal neurodevelopment is dysregulated in purine metabolism deficiency and impacts darpp-32, BDNF/TrkB expression and signaling: new insights on the molecular and cellular basis of Lesch-Nyhan syndrome. PLoS One 9:e96575CrossRefPubMedPubMedCentral

Hague SM, Klaffke S, Bandmann O (2005) Neurodegenerative disorders: Parkinson’s disease and Huntington’s disease. J Neurol Neurosurg Psychiatry 76:1058–1063CrossRefPubMedPubMedCentral

Hardy OT, Czecha MP, Corvera S (2012) What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes 19:81–87CrossRefPubMedPubMedCentral

Hayashi A, Kasahara T, Iwamoto K, Ishiwata M, Kametani M, Kakiuchi C, Furuichi T, Kato T (2007) The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development. J Biol Chem 282:34525–34534CrossRefPubMed

Herskovits AZ, Guarente L (2014) SIRT1 in neurodevelopment and brain senescence. Neuron 81:471–483CrossRefPubMedPubMedCentral

Hert MD, Schreursl V, Vancampfort D, Winkel RV (2009) Metabolic syndrome in people with schizophrenia:a review. World Psychiatry 8:15–22CrossRef

Hristova M, Atanassova P (2016) Plasma levels of cortisol, leptin and an expression of the leptin receptors in the visceral adipose tissue in case of metabolic syndrome. J Endocrinol Diabetes Obes 4:1086

Hu Y, Russek SJ (2008) BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation. J Neurochem 105:1–17CrossRefPubMed

Huang WH, Guenthner CJ, Xu J, Nguyen T, Schwarz LA, Wilkinson AW, Gozani O, Chang HY, Shamloo M, Luo L (2016) Molecular and neural functions of Rai1, the causal gene for Smith-Magenis syndrome. Neuron 92:1–15CrossRef

Ibarguen-Vargas Y, Surget A, Vourch P, Leman S, Andres CR, Gardier AM, Belzung C (2009) Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress. Behav Brain Res 202:245–251CrossRefPubMed

Kahn R, Buse J, Ferrannini E, Stern M (2005) The metabolic syndrome: time for a critical appraisal. Diabetes Care 28:2289–2304CrossRefPubMed

Karczewska-Kupczewska M, Strączkowski M, Adamska A, Nikołajuk A, Otziomek E, Górska M, Kowalska I (2011) Decreased serum brain-derived neurotrophic factor concentration in young nonobese subjects with low insulin sensitivity. Clin Biochem 44:817–820CrossRefPubMed

Karimi I (2012) Animal models as tools for translational research: focus on atherosclerosis, metabolic syndrome and type ІІ diabetes mellitus. Lipoproteins – role in health and diseases, edited by Saša frank and Gerhard Kostner. ISBN 978-953-51-0773-6, chapter 21, 509-510

Kaur J (2014) A comprehensive review on metabolic syndrome. Cardiol Res Practice 2014, Article ID 943162, 21 pages

Kelli HM, Kassas I, Lattouf OM (2015) Cardio metabolic syndrome: a global epidemic. J Diabetes Met 6:513

Kereiakes DJ, Willerson JT (2003) Metabolic syndrome epidemic. Circulation 108:1552–1553CrossRefPubMed

Koronowski KB, Perez-Pinzon MA (2015) Sirt1 in cerebral ischemia. Brain Circ 1:69–78CrossRefPubMedPubMedCentral

Lee IT, Fu CP, Lee WJ, Liang KW, Lin SY, Wan CJ, Sheu WHH (2014) Brain-derived neurotrophic factor, but not body weight, correlated with a reduction in depression scale scores in men with metabolic syndrome: a prospective weight-reduction study. Diabetes Metab Syndr 6:1–7CrossRef

Martins IJ (2013) Increased risk for obesity and diabetes with neurodegeneration in developing countries. J Mol Genet Med, doi:10.4172/1747-0862.S1-001

Moghbelinejad S, Nassiri-Asl M, Naserpour T, Abbasi EM, Taghiloo M, Farsad F, Samimie A, Hajiali F (2014) Rutin activates the MAPK pathway and BDNF gene expression on beta-amyloid induced neurotoxicity in rats. Toxicol Lett 224:108–113CrossRefPubMed

Molteni R, Barnard J, Ying Z, Roberts CK, Gomez-Pinilla F (2002) A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neurosci 112:803–814CrossRef

Morales-Marín ME, Genis-Mendoza AD, Tovilla-Zarate CA, Lanzagorta N, Escamilla M, Nicolini H (2016) Association between obesity and the brain-derived neurotrophic factor gene polymorphism Val66Met in individuals with bipolar disorder in Mexican population. Neuropsychiatr Dis Treat 12:1843–1848CrossRefPubMedPubMedCentral

Murray P, Holmes P (2011) An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus. Int J Pept. doi:10.1155/2011/654085 PubMedPubMedCentral

Mys’liwiec MM, Cichocka E, Dziedziejko V, Dutkiewicz GY, Stepniewska J, Safranow K, Budkowska M, Sałata D, Syrenicz A, Machalin’ski B, Ciechanowski K (2014) Insulin resistance and brain-derived neurotrophic factor levels in chronic kidney disease. Ann Clin Biochem 0:1–7

Nakagomi A, Okada S, Yokoyama M, Yoshida Y, Shimizu I, Miki T, Kobayashi Y, Minamino T (2015) Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation. Aging Mech Dis, doi:10.1038/npjamd.2015.9

Neary NM, Goldstone AP, Bloom SR (2004) Appetite regulation: from the gut to the hypothalamus. Clin Endocrinol 60:153–160CrossRef

Nemeroff CB, Owens MJ (2009) The role of serotonin in the pathophysiology of depression: as important as ever. Clin Chem 55:1578–1579CrossRefPubMed

Ng F, Wijaya L, Tang BL (2015) SIRT1 in the brain-connections with aging-associated disorders and lifespan. Front cell Neurosci 9

Nimmagadda VK, Bever CT, Vattikunta NR, Talat S, Ahmad V, Nagalla NK, Trisler D, Judge SIV, Royal W III, Chandrasekaran K, Russell JW, Makar TK (2013) Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets. J Immunol 190:4595–4607PubMedPubMedCentral

O'Bryant SE, Hobson V, Hall JR, Waring SC, Chan W, Massman P, Lacritz L, Cullum M, Diaz-Arrastia R (2009) Brain-derived neurotrophic factor levels in Alzheimer's disease. J Alzheimers Dis 17:337–341CrossRefPubMedPubMedCentral

Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37:1553–1561CrossRefPubMed

Roberts CK, Hevener AL, Barnard RJ (2013) Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol 3:1–58PubMedPubMedCentral

Singh RB, Takahashi T, Tokunaga M, Wilczynska A, Chee J, Kim CJ, Meester FD, Darlenska TH, Cheema SK, Wilson DW, Milovanovic B, Fedacko J, Hristova K, Chaves H (2014) Effect of brain derived neurotrophic factor, in relation to diet and lifestyle factors, for prevention of neuropsychiatric and vascular diseases and diabetes. Open Nutr J 7:5–14

Sleiman SF, Henry J, Al-Haddad R, Hayek L, Abou Haidar E, Stringer T, Ulja D, Karuppagounder SS, Holson EB, Ratan RR, Ninan I, Chao MV (2016) Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body b-hydroxybutyrate. E Life 5:5092

Smith AJ, Malan L, Uys AS, Malan NT, Harvey BH, Ziemssen T (2015) Attenuated brain-derived neurotrophic factor and hypertrophic remodelling: the SABPA study. J Hum Hypertens 29:33–39CrossRefPubMed

Srikanthan K, Feyh A, Visweshwar H, Shapiro JI, Sodhi K (2016) Systematic review of metabolic syndrome biomarkers: a panel for early detection, management, and risk stratification in the west virginian population. Int J Med Sci 13:25–38CrossRefPubMedPubMedCentral

Suriyaprom K, Tungtrongchitr R, Thawnasom K (2014) Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome. Diabetol Metab Syndr 6:1–9CrossRef

Taha AY, Gao F, Ramadan E, Cheon Y, Rapoport SI, Kim HW (2012) Upregulated expression of brain enzymatic markers of arachidonic and docosahexaenoic acid metabolism in a rat model of the metabolic syndrome. BMC Neurosci 13:131CrossRefPubMedPubMedCentral

Takei N, Furukawa K, Hanyu O, Sone H, Nawa H (2014) A possible link between BDNF and mTOR in control of food intake. Front Psychol 5:1–6CrossRef

Teillon S, Calderon GA, Rios M (2010) Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARa and FGF21 in mice with hepatic ablation of brain-derived neurotropic factor. J Endocrinol 205:37–47CrossRefPubMed

Unger TJ, Calderon GA, Bradley LC, Esteves MS, Rios M (2007) Selective deletion of BDNF in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 27:14265–14274CrossRefPubMed

Wang J, He M (2014) Levels of serum brain-derived neurotrophic factor in type 2 diabetes mellitus patients with and without depressive symptoms. Acta Biochim Biophys Sin 47:137–138CrossRefPubMed

Xu J, Stanislaus S, Chinookoswong N, Lau YY, Hager T, Patel J, Ge H, Weiszmann J, Lu SC, Graham M, Busby J, Hecht R, Li YS, Li Y, Lindberg RA, Veniant MM (2009) Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin resistant mouse models. Association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab 297:E1105–E1114CrossRefPubMed

Yamanaka M, Itakura Y, Tsuchida A, Nakagawa T, Noguchi H, Taiji M (2007) Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice. Diabetes Obes Metab 9:879–888CrossRefPubMed

Zimmet P, Alberti G (2008) The metabolic syndrome: progress towards one definition for an epidemic of our time. Natclin Pract Endocrinol Metab 4:239CrossRef

Zocchi L, Sassone-Corsi P (2012) SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression. Epigenetics 7:695–700CrossRefPubMedPubMedCentral

Zuccato C, Cattaneo E (2007) Role of brain-derived neurotrophic factor in Huntington’s disease. Prog Neurobiol 81:294–330CrossRefPubMed

Titel: The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone
verfasst von: Shima Motamedi
Isaac Karimi
Fariba Jafari
Publikationsdatum: 30.03.2017
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 3/2017
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-9997-0

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2017

Characterization of the CA1 pyramidal neurons in rat model of hepatic cirrhosis: insights into their electrophysiological properties

Protective effect of tropisetron on high glucose induced apoptosis and oxidative stress in PC12 cells: roles of JNK, P38 MAPKs, and mitochondria pathway

Serum trace elements are associated with hemostasis, lipid spectrum and inflammatory markers in men suffering from acute ischemic stroke

Diabetic brain or retina? Visual psychophysical performance in diabetic patients in relation to GABA levels in occipital cortex

Curcumin attenuates surgery-induced cognitive dysfunction in aged mice