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Journal of Cardiovascular Translational Research

Erschienen in:

13.12.2019 | Review

The Level of Circulating Microparticles in Patients with Coronary Heart Disease: a Systematic Review and Meta-Analysis

verfasst von: Baofu Wang, Tong Li, Xiaowan Han, Yang Li, Wenkun Cheng, Lei Wang, Ziwen Lu, Jingjing Yang, Mingjing Zhao

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 5/2020

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Abstract

Background/Aims

To assess the correlation between microparticles (MPs) and subgroups of coronary heart disease (CHD), including stable angina (SA), unstable angina (UA), and myocardial infarction (MI).

Methods

A literature search was carried out systematically to identify available case–control studies. The level of MPs was compared and MPs’ merged standardized mean differences (SMDs) were pooled for the meta-analysis.

Results

Six studies met the inclusion criteria and were used for systematic review and meta-analysis. The level of MPs was higher in patients with CHD than that in the NS (normal subjects) group (SMD 2.28; 95% confidence interval (CI) 1.70–2.85; P = 0.000), and was also significantly different in subgroups of CHD (UA vs SA: SMD 2.35, 95% CI 1.56–3.14, P = 0.000; MI vs SA: SMD 3.08, 95% CI 2.07–4.09, P = 0.000; MI vs UA: SMD 0.83, 95% CI 0.41–1.26, P = 0.000). The similar results were also found in subgroups analyses of CD31⁺CD42⁻ endothelium-derived microparticles (EMPs) and CD144⁺EMPs.

Conclusion

The level of MPs, especially CD31⁺CD42⁻EMPs and CD144⁺EMPs, had an increasing trend with the degree of CHD: NS<SA<UA<MI, suggesting that MPs might be a potential biomarker to identify SA, UA, and MI.

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Thomas, H., Diamond, J., Vieco, A., Chaudhuri, S., Shinnar, E., Cromer, S., et al. (2018). Global atlas of cardiovascular disease 2000-2016: the path to prevention and control. Global Heart, 13(3), 143–163. https://doi.org/10.1016/j.gheart.2018.09.511.CrossRefPubMed

Fernández, M., & Calligaris, S. D. (2019). Circulating microparticles in cardiovascular disease: going on stage. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 24(5), 423–428. https://doi.org/10.1080/1354750X.2019.1616822.CrossRef

Boulanger, C. M., Loyer, X., Rautou, P. E., & Amabile, N. (2017). Extracellular vesicles in coronary artery disease. Nature Reviews. Cardiology, 14, 259–272. https://doi.org/10.1038/nrcardio.2017.7.CrossRefPubMed

Hafiane, A., & Daskalopoulou, S. S. (2018). Extracellular vesicles characteristics and emerging roles in atherosclerotic cardiovascular disease. Metabolism, Clinical and Experimental, 85, 213–222. https://doi.org/10.1016/j.metabol.2018.04.008.CrossRef

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., et al. (2018). Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of extracellular vesicles, 7(1), 1535750. https://doi.org/10.1080/20013078.2018.1535750.CrossRefPubMedPubMedCentral

Koganti, S., Eleftheriou, D., Brogan, P. A., Kotecha, T., Hong, Y., & Rakhit, R. D. (2017). Microparticles and their role in coronary artery disease. International Journal of Cardiology, 230, 339–345. https://doi.org/10.1016/j.ijcard.2016.12.108.CrossRefPubMed

Liu, Y., He, Z., Zhang, Y., Dong, Z., Bi, Y., Kou, J., et al. (2016). Dissimilarity of increased phosphatidylserine-positive microparticles and associated coagulation activation in acute coronary syndromes. Coronary Artery Disease, 27, 365–375. https://doi.org/10.1097/MCA.0000000000000368.CrossRefPubMed

Biasucci, L. M., Porto, I., Di Vito, L., De Maria, G. L., Leone, A. M., Tinelli, G., et al. (2012). Differences in microparticle release in patients with acute coronary syndrome and stable angina. Circulation Journal, 76, 2174–2182. https://doi.org/10.1253/circj.cj-12-0068.CrossRefPubMed

Sarlon-Bartoli, G., Bennis, Y., Lacroix, R., Piercecchi-Marti, M. D., Bartoli, M. A., Arnaud, L., et al. (2013). Plasmatic level of leukocyte-derived microparticles is associated with unstable plaque in asymptomatic patients with high-grade carotid stenosis. Journal of the American College of Cardiology, 62, 1436–1441. https://doi.org/10.1016/j.jacc.2013.03.078.CrossRefPubMed

10.

Suades, R., Padró, T., Crespo, J., Ramaiola, I., Martin-Yuste, V., Sabaté, M., et al. (2016). Circulating microparticle signature in coronary and peripheral blood of ST elevation myocardial infarction patients in relation to pain-to-PCI elapsed time. International Journal of Cardiology, 202, 378–387. https://doi.org/10.1016/j.ijcard.2015.09.011.CrossRefPubMed

11.

Sun, C., Zhao, W. B., Chen, Y., & Hu, H. Y. (2016). Higher plasma concentrations of platelet microparticles in patients with acute coronary syndrome: a systematic review and meta-analysis. The Canadian Journal of Cardiology, 32, 1325.e1–1325.e10. https://doi.org/10.1016/j.cjca.2016.02.052.CrossRef

12.

Wang, Z., Cai, W., Hu, S., Xia, Y., Wang, Y., Zhang, Q., et al. (2017). A meta-analysis of circulating microvesicles in patients with myocardial infarction. Arquivos Brasileiros de Cardiologia , 0. doi: https://doi.org/10.5935/abc.20170102.

13.

Yuan, Y. J., Muyesai, N., & Abdeyrim, A. (2018). Comparison of erythrocyte microparticle levels between acute coronary syndrome and stable angina pectoris patients. International Journal of Clinical and Experimental Medicine, 11, 9528–9535.

14.

Fu, Y.Y. (2008) Application of flow cytometry in estimation of microparticles and its clinical significance. [dissertation/master’s thesis]. Zhejiang University.

15.

Cui, Y., Zheng, L., Jiang, M., Jia, R., Zhang, X., Quan, Q., et al. (2013). Circulating microparticles in patients with coronary heart disease and its correlation with interleukin-6 and C-reactive protein. Molecular Biology Reports, 40, 6437–6442. https://doi.org/10.1007/s11033-013-2758-1.CrossRefPubMed

16.

Lu, Y., Li, L., Yan, H., Su, Q., Huang, J., & Fu, C. (2013). Endothelial microparticles exert differential effects on functions of Th1 in patients with acute coronary syndrome. International Journal of Cardiology, 168, 5396–5404. https://doi.org/10.1016/j.ijcard.2013.08.050.CrossRefPubMed

17.

Shen, H. Y., Chen, Y. R., and Shen, J. L. (2015). Dynamic changes and clinical significance of EMPs, Th cytokines levels in patients with coronary heart disease. Laboratory Medicine & Clinic .

18.

Zhang, W., Chen, W. Q., Zhu, B., Pan, X. Y., & Zhao, L. N. (2017). Changes and clinical significance of peripheral blood endothelial cell membrane particles and helper T cell cytokines in patients with coronary heart disease. International Journal of Laboratory Medicine., 38(02), 245–247.

19.

Nomura, S., Uehata, S., Saito, S., Osumi, K., Ozeki, Y., & Kimura, Y. (2003). Enzyme immunoassay detection of platelet-derived microparticles and RANTES in acute coronary syndrome. Thrombosis and Haemostasis, 89, 506–512.CrossRef

20.

Shah, R., Patel, T., & Freedman, J. E. (2018). Circulating extracellular vesicles in human disease. The New England Journal of Medicine, 379, 2180–2181. https://doi.org/10.1056/NEJMc1813170.CrossRefPubMed

21.

Boulanger, C. M., Amabile, N., & Tedgui, A. (2006). Circulating microparticles: a potential prognostic marker for atherosclerotic vascular disease. Hypertension, 48(2), 180–186. https://doi.org/10.1161/01.HYP.0000231507.00962.b5.CrossRefPubMed

22.

Jansen, F., Yang, X., Franklin, B. S., Hoelscher, M., Schmitz, T., Bedorf, J., et al. (2013). High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation. Cardiovascular Research, 98, 94–106. https://doi.org/10.1093/cvr/cvt013.CrossRefPubMed

23.

Badimon, L., Suades, R., Fuentes, E., Palomo, I., & Padró, T. (2016). Role of platelet-derived microvesicles as crosstalk mediators in atherothrombosis and future pharmacology targets: a link between inflammation, atherosclerosis, and thrombosis. Frontiers in Pharmacology, 7, 293. https://doi.org/10.3389/fphar.2016.00293.CrossRefPubMedPubMedCentral

24.

Martínez, M. C., & Andriantsitohaina, R. (2017). Extracellular vesicles in metabolic syndrome. Circulation Research, 120, 1674–1686. https://doi.org/10.1161/CIRCRESAHA.117.309419.CrossRefPubMed

25.

Shao, H., Im, H., Castro, C. M., Breakefield, X., Weissleder, R., & Lee, H. (2018). New technologies for analysis of extracellular vesicles. Chemical Reviews, 118, 1917–1950. https://doi.org/10.1021/acs.chemrev.7b00534.CrossRefPubMedPubMedCentral

26.

Porto, I., Biasucci, L. M., De Maria, G. L., Leone, A. M., Niccoli, G., Burzotta, F., et al. (2012). Intracoronary microparticles and microvascular obstruction in patients with ST elevation myocardial infarction undergoing primary percutaneous intervention. European Heart Journal, 33, 2928–2938. https://doi.org/10.1093/eurheartj/ehs065.CrossRefPubMed

27.

Bernal-Mizrachi, L., Jy, W., Jimenez, J. J., Pastor, J., Mauro, L. M., Horstman, L. L., et al. (2003). High levels of circulating endothelial microparticles in patients with acute coronary syndromes. American Heart Journal, 145, 962–970. https://doi.org/10.1016/S0002-8703(03)00103-0.CrossRefPubMed

28.

Sinning, J. M., Losch, J., Walenta, K., Böhm, M., Nickenig, G., & Werner, N. (2011). Circulating CD31+/annexin V+ microparticles correlate with cardiovascular outcomes. European Heart Journal, 32, 2034–2041. https://doi.org/10.1093/eurheartj/ehq478.CrossRefPubMed

29.

Lee, S. T., Chu, K., Jung, K. H., Kim, J. M., Moon, H. J., Bahn, J. J., et al. (2012). Circulating CD62E+ microparticles and cardiovascular outcomes. PLoS One, 7, e35713. https://doi.org/10.1371/journal.pone.0035713.CrossRefPubMedPubMedCentral

30.

Kanhai, D. A., Visseren, F. L., van der Graaf, Y., Schoneveld, A. H., Catanzariti, L. M., Timmers, L., et al. (2013). Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease. International Journal of Cardiology, 168, 2358–2363. https://doi.org/10.1016/j.ijcard.2013.01.231.CrossRefPubMed

31.

Yong, P. J., Koh, C. H., & Shim, W. S. (2013). Endothelial microparticles: missing link in endothelial dysfunction. European Journal of Preventive Cardiology, 20, 496–512. https://doi.org/10.1177/2047487312445001.CrossRefPubMed

32.

Paone, S., Baxter, A. A., Hulett, M. D., & Poon, I. (2019). Endothelial cell apoptosis and the role of endothelial cell-derived extracellular vesicles in the progression of atherosclerosis. Cellular and Molecular Life Sciences: CMLS, 76(6), 1093–1106. https://doi.org/10.1007/s00018-018-2983-9.CrossRefPubMed

33.

Radecke, C. E., Warrick, A. E., Singh, G. D., Rogers, J. H., Simon, S. I., & Armstrong, E. J. (2015). Coronary artery endothelial cells and microparticles increase expression of VCAM-1 in myocardial infarction. Thrombosis and Haemostasis, 113(3), 605–616. https://doi.org/10.1160/TH14-02-0151.CrossRefPubMed

34.

Dozio, V., & Sanchez, J. C. (2017). Characterisation of extracellular vesicle-subsets derived from brain endothelial cells and analysis of their protein cargo modulation after TNF exposure. Journal of extracellular vesicles, 6(1), 1302705. https://doi.org/10.1080/20013078.2017.1302705.CrossRefPubMedPubMedCentral

35.

Li-Na, A. N., Dong, F. F., & Wang, G. K. (2012). Circulating miRNAs as diagnosis biomarkers for cardiovascular diseases. Academic Journal of Second Military Medical University, 32, 1365–1367.

36.

Murach, K. A., & Mccarthy, J. J. (2016). MicroRNAs, heart failure, and aging: potential interactions with skeletal muscle. Heart Failure Reviews, 1–10.

37.

Lin, F., Zhao, G., Chen, Z., Wang, X., Lv, F., Zhang, Y., et al. (2019). circRNA-miRNA association for coronary heart disease. Molecular Medicine Reports, 19(4), 2527–2536.PubMedPubMedCentral

38.

Zhang, Y., Cheng, J., Chen, F., Wu, C., Zhang, J., Ren, X., et al. (2017). Circulating endothelial microparticles and miR-92a in acute myocardial infarction. Bioscience Reports, 37, BSR20170047.CrossRef

39.

Li, H., Zhang, P., Li, F., Yuan, G., Wang, X., Zhang, A., et al. (2019). Plasma miR-22-5p, miR-132-5p, and miR-150-3p are associated with acute myocardial infarction. BioMed Research International, 2019, 5012648. https://doi.org/10.1155/2019/5012648.CrossRefPubMedPubMedCentral

40.

Velle-Forbord, T., Eidlaug, M., Debik, J., Sæther, J. C., Follestad, T., Nauman, J., et al. (2019). Circulating microRNAs as predictive biomarkers of myocardial infarction: evidence from the HUNT study. Atherosclerosis, 289, 1–7. https://doi.org/10.1016/j.atherosclerosis.2019.07.024.CrossRefPubMed

41.

Chistiakov, D. A., Orekhov, A. N., & Bobryshev, Y. V. (2016). Cardiac extracellular vesicles in normal and infarcted heart. International Journal of Molecular Sciences, 17(1). https://doi.org/10.3390/ijms17010063.

42.

Ayers, L., Kohler, M., Harrison, P., Sargent, I., Dragovic, R., Schaap, M., et al. (2011). Measurement of circulating cell-derived microparticles by flow cytometry: sources of variability within the assay. Thrombosis Research, 127(4), 370–377. https://doi.org/10.1016/j.thromres.2010.12.014.CrossRefPubMed

43.

Montoro-García, S., Shantsila, E., Tapp, L. D., López-Cuenca, A., Romero, A. I., Hernández-Romero, D., et al. (2013). Small-size circulating microparticles in acute coronary syndromes: relevance to fibrinolytic status, reparative markers and outcomes. Atherosclerosis, 227(2), 313–322. https://doi.org/10.1016/j.atherosclerosis.2013.01.028.CrossRefPubMed

44.

Hu, S.S.(2014) Endothelial cell injury in patients with hypertension-endothelial microparticles and platelet-derived microparticles and its clinical significance [dissertation/master’s thesis]. Peking Union Medical College.

Titel: The Level of Circulating Microparticles in Patients with Coronary Heart Disease: a Systematic Review and Meta-Analysis
verfasst von: Baofu Wang
Tong Li
Xiaowan Han
Yang Li
Wenkun Cheng
Lei Wang
Ziwen Lu
Jingjing Yang
Mingjing Zhao
Publikationsdatum: 13.12.2019
Verlag: Springer US
Erschienen in: Journal of Cardiovascular Translational Research / Ausgabe 5/2020
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-019-09945-7

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