nach oben

European Archives of Oto-Rhino-Laryngology

Erschienen in:

13.04.2018 | Review Article

The lymphocyte-to-monocyte ratio as a prognostic indicator in head and neck cancer: a systematic review and meta-analysis

verfasst von: Tristan Tham, Caitlin Olson, Julian Khaymovich, Saori Wendy Herman, Peter David Costantino

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 7/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The aim of this systematic review and meta-analysis was to investigate the relationship between the pre-treatment lymphocyte-to-monocyte ratio (LMR) and prognosis in HNC.

Methods

PubMed (via the Web), Embase, Scopus, and the Cochrane Library were searched. A systematic review and meta-analysis was done to generate the pooled hazard ratios (HR) for overall survival (OS) and disease-free survival (DFS).

Results

Our analysis included the results of 4260 patients in seven cohorts. The pooled data demonstrated that an elevated LMR was associated with significantly improved OS (HR 0.5; 95% CI 0.44–0.57), and DFS (HR 0.70; 95% CI 0.62–0.80). Of note, there was no detectable heterogeneity in either OS (I² = 0%) or DFS (I² = 0%).

Conclusions

An elevated LMR may be an indicator of favorable prognosis in HNC. However, our results should be interpreted with some degree of caution due to the retrospective nature of cohort studies. Further research with high-quality prospective studies is needed to confirm the effect of LMR in HNC prognosis.

Nur mit Berechtigung zugänglich

Jemal A, Bray F, Center MM et al (2011) Global cancer statistics. CA Cancer J Clin 61(2):69–90CrossRefPubMed

Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140(6):883–99CrossRefPubMedPubMedCentral

O’callaghan DS, O’donnell D, O’connell F, O’byrne KJ (2010) The role of inflammation in the pathogenesis of non-small cell lung cancer. J Thorac Oncol 5(12):2024–2036CrossRefPubMed

Aggarwal BB, Vijayalekshmi R, Sung B (2009) Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res 15(2):425–30CrossRefPubMed

Teng J-J, Zhang J, Zhang T-Y, Zhang S, Li B-S (2016) Prognostic value of peripheral blood lymphocyte-to-monocyte ratio in patients with solid tumors: a meta-analysis. Onco Targets Ther 9:37PubMed

Su L, Zhang M, Zhang W, Cai C, Hong J (2017) Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis. Medicine 96(11):e6364CrossRefPubMedPubMedCentral

Macaskill P, Gatsonis C, Deeks J, Harbord R, Takwoingi Y. Cochrane handbook for systematic reviews of diagnostic test accuracy. Version 09 0 London: The Cochrane Collaboration. 2010

Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097CrossRefPubMedPubMedCentral

Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 283(15):2008–2012CrossRefPubMed

10.

PROSPERO ID:80658 [Internet]. 2017. Available from: https://www.crd.york.ac.uk/prospero/ [Pending Approval]

11.

Hayden JA, van der Windt DA, Cartwright JL, Côté P, Bombardier C (2013) Assessing bias in studies of prognostic factors. Ann Intern Med 158(4):280–286CrossRefPubMed

12.

Hsueh C, Tao L, Zhang M et al (2017) The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer. Oncotarget 8(36):60514CrossRefPubMedPubMedCentral

13.

Szekely G, Remenar E, Kasler M, Bodrog A, Gundy S (2001) Validity of chromosome analysis and bleomycin sensitivity assay in the prevention of head and neck cancer in Hungary. Orv Hetil 142(12):611–616PubMed

14.

Rosenthal R (1979) The file drawer problem and tolerance for null results. Psychol Bull 86(3):638CrossRef

15.

Suurmond R, Rhee H, Hak T (2017) Introduction, comparison, and validation of Meta‐Essentials: a free and simple tool for meta‐analysis. Res Synth Methods 8(4):537–553CrossRef

16.

Li J, Jiang R, Liu W-S et al (2013) A large cohort study reveals the association of elevated peripheral blood lymphocyte-to-monocyte ratio with favorable prognosis in nasopharyngeal carcinoma. PLoS One 8(12):e83069CrossRefPubMedPubMedCentral

17.

Li MX, Liu XM, Zhang XF et al (2014) Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis. Int J Cancer 134(10):2403–2413CrossRefPubMed

18.

Jiang R, Cai X-Y, Yang Z-H et al (2015) Elevated peripheral blood lymphocyte-to-monocyte ratio predicts a favorable prognosis in the patients with metastatic nasopharyngeal carcinoma. Chin J Cancer 34(3):23CrossRefPubMedCentral

19.

Kano S, Homma A, Hatakeyama H et al (2017) Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer. Head Neck 39(2):247–53CrossRefPubMed

20.

Ong HS, Gokavarapu S, Wang LZ, Tian Z, Zhang CP (2016) Low pretreatment lymphocyte–monocyte ratio and high platelet–lymphocyte ratio indicate poor cancer outcome in early tongue cancer. J Oral Maxillofac Surg 75(8):1762–1774

21.

Lin G-N, Peng J-W, Liu D-Y et al (2014) Increased lymphocyte to monocyte ratio is associated with better prognosis in patients with newly diagnosed metastatic nasopharyngeal carcinoma receiving chemotherapy. Tumor Biol 35(11):10849–10854CrossRef

22.

Li XH, Chang H, Xu BQ et al (2016) An inflammatory biomarker-based nomogram to predict prognosis of patients with nasopharyngeal carcinoma: an analysis of a prospective study. Cancer Med 6(1):310–319

23.

Ryan R; Cochrane Consumers and Communication Review Group (2016) Heterogeneity and subgroup analyses in cochrane consumers and communication group reviews: planning the analysis at protocol stage. http://cccrg.cochrane.org

24.

Lu H, Ouyang W, Huang C (2006) Inflammation, a key event in cancer development. Mol Cancer Res 4(4):221–33CrossRefPubMed

25.

Gooden MJ, de Bock GH, Leffers N, Daemen T, Nijman HW (2011) The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis. Br J Cancer 105(1):93–103CrossRefPubMedPubMedCentral

26.

Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4(1):71–8CrossRefPubMed

27.

Xiong M, Elson G, Legarda D, Leibovich SJ (1998) Production of vascular endothelial growth factor by murine macrophages: regulation by hypoxia, lactate, and the inducible nitric oxide synthase pathway. Am J Pathol 153(2):587–98CrossRefPubMedPubMedCentral

28.

Lin G-N, Peng J-W, Xiao J-j, Liu D-Y, Xia Z-J (2014) Prognostic impact of circulating monocytes and lymphocyte-to-monocyte ratio on previously untreated metastatic non-small cell lung cancer patients receiving platinum-based doublet. Med Oncol 31(7):70CrossRefPubMed

29.

Zhang G-M, Zhu Y, Luo L et al (2015) Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy. Tumor Biol 36(11):8537–8543CrossRef

30.

Qi Q, Geng Y, Sun M, Wang P, Chen Z (2015) Clinical implications of systemic inflammatory response markers as independent prognostic factors for advanced pancreatic cancer. Pancreatology 15(2):145–50CrossRefPubMed

31.

Szkandera J, Gerger A, Liegl-Atzwanger B et al (2014) The lymphocyte/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas. Int J Cancer 135(2):362–70CrossRefPubMed

32.

Templeton AJ, McNamara MG, Šeruga B et al (2014) Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst 106(6):dju124CrossRefPubMed

33.

McMillan DC (2013) The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. Cancer Treat Rev 39(5):534–40CrossRefPubMed

Titel: The lymphocyte-to-monocyte ratio as a prognostic indicator in head and neck cancer: a systematic review and meta-analysis
verfasst von: Tristan Tham
Caitlin Olson
Julian Khaymovich
Saori Wendy Herman
Peter David Costantino
Publikationsdatum: 13.04.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 7/2018
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-4972-x

Neu im Fachgebiet HNO

16.04.2024 | HNO-Chirurgie | Nachrichten

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

The lymphocyte-to-monocyte ratio as a prognostic indicator in head and neck cancer: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2018

Anatomical variations of the ethmoidal roof: differences between men and women

Provox 2® and Provox Vega® device life-time: a case-crossover study with multivariate analysis of possible influential factors and duration

Identification of dizzy patients who will develop an acute cerebrovascular syndrome: a descriptive study among emergency department patients

Evaluation of a new slim lateral wall electrode for cochlear implantation: an imaging study in human temporal bones

Complications in septoplasty based on a large group of 5639 patients

Effects of “trigeminal training” on trigeminal sensitivity and self-rated nasal patency

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO