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Erschienen in: Current Urology Reports 2/2021

01.02.2021 | Men's Health (R Carrion, Section Editor)

The Management of Penile Fracture: a Review of the Literature with Special Consideration for Patients Undergoing Collagenase Clostridium Histolyticum Injection Therapy

verfasst von: William M. Hughes, Caleb Natale, Wayne J. G. Hellstrom

Erschienen in: Current Urology Reports | Ausgabe 2/2021

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Abstract

Purpose of Review

To review the current literature on acute management of traumatic penile fracture, with a specific discussion of those injuries following collagenase clostridium histolyticum (CCH) injections for the treatment of Peyronie’s disease.

Recent Findings

The immediate repair of traumatic penile fracture injury is associated with significantly better prognosis for long-term sexual health. Corporal disruption following CCH administration has several distinct features, and the trend is to manage these patients conservatively in the absence of urethral injury.

Summary

Traumatic penile fracture repair continues to have excellent results when performed immediately following injury. The post-CCH treatment setting portends increased difficulty during surgical management and can be successfully managed in most cases by conservative measures.
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Literatur
1.
Zurück zum Zitat Barros R, Hampl D, Cavalcanti AG, Favorito LA, Koifman L. Lessons learned after 20 years' experience with penile fracture. Int Braz J Urol. 2020;46(3):409–16.CrossRef Barros R, Hampl D, Cavalcanti AG, Favorito LA, Koifman L. Lessons learned after 20 years' experience with penile fracture. Int Braz J Urol. 2020;46(3):409–16.CrossRef
2.
Zurück zum Zitat Zargooshi J. Sexual function and tunica albuginea wound healing following penile fracture: an 18-year follow-up study of 352 patients from Kermanshah, Iran. J Sex Med. 2009;6(4):1141–50.CrossRef Zargooshi J. Sexual function and tunica albuginea wound healing following penile fracture: an 18-year follow-up study of 352 patients from Kermanshah, Iran. J Sex Med. 2009;6(4):1141–50.CrossRef
3.
Zurück zum Zitat Falcone M, Garaffa G, Castiglione F, Ralph DJ. Current management of penile fracture: an up-to-date systematic review. Sex Med Rev. 2018;6(2):253–60.CrossRef Falcone M, Garaffa G, Castiglione F, Ralph DJ. Current management of penile fracture: an up-to-date systematic review. Sex Med Rev. 2018;6(2):253–60.CrossRef
4.
Zurück zum Zitat Fernstrom U. Rupture of the penis. Report of one operated case and review of literature. Acta Chir Scand. 1957;113(3):211–7.PubMed Fernstrom U. Rupture of the penis. Report of one operated case and review of literature. Acta Chir Scand. 1957;113(3):211–7.PubMed
5.
Zurück zum Zitat Dias-Filho AC, Fregonesi A, Martinez CAT, Pimentel ES, Riccetto CLZ. Can the snapping sound discriminate true from false penile fractures? Bayesian analysis of a case series of consecutively treated penile fracture patients. Int J Impot Res. 2020;32(4):446–454 Dias-Filho AC, Fregonesi A, Martinez CAT, Pimentel ES, Riccetto CLZ. Can the snapping sound discriminate true from false penile fractures? Bayesian analysis of a case series of consecutively treated penile fracture patients. Int J Impot Res. 2020;32(4):446–454
6.
Zurück zum Zitat Izzo L, Izzo S, Pugliese F, Izzo P, Messineo D, Selvaggi F, et al. The role of imaging in penile fracture our experience. Ann Ital Chir. 2019;90:330–4.PubMed Izzo L, Izzo S, Pugliese F, Izzo P, Messineo D, Selvaggi F, et al. The role of imaging in penile fracture our experience. Ann Ital Chir. 2019;90:330–4.PubMed
7.
Zurück zum Zitat Cozzi D, Verrone GB, Agostini S, Bartolini M, D’Amico G, Pradella S, et al. Acute penile trauma: imaging features in the emergency setting. Radiol Med. 2019;124(12):1270–80.CrossRef Cozzi D, Verrone GB, Agostini S, Bartolini M, D’Amico G, Pradella S, et al. Acute penile trauma: imaging features in the emergency setting. Radiol Med. 2019;124(12):1270–80.CrossRef
8.
Zurück zum Zitat Panayiotou A, Huang DY, Makanjuola JK, Sidhu PS. Penile fracture: added value of novel assessment with contrast-enhanced ultrasound. BMJ Case Rep. 2019;12(7):e230864 Panayiotou A, Huang DY, Makanjuola JK, Sidhu PS. Penile fracture: added value of novel assessment with contrast-enhanced ultrasound. BMJ Case Rep. 2019;12(7):e230864
10.
Zurück zum Zitat Sokolakis I, Schubert T, Oelschlaeger M, Krebs M, Gschwend JE, Holzapfel K, et al. The role of magnetic resonance imaging in the diagnosis of penile fracture in real-life emergency settings: comparative analysis with intraoperative findings. J Urol. 2019;202(3):552–7.CrossRef Sokolakis I, Schubert T, Oelschlaeger M, Krebs M, Gschwend JE, Holzapfel K, et al. The role of magnetic resonance imaging in the diagnosis of penile fracture in real-life emergency settings: comparative analysis with intraoperative findings. J Urol. 2019;202(3):552–7.CrossRef
12.
Zurück zum Zitat Zare Mehrjardi M, Darabi M, Bagheri SM, Kamali K, Bijan B. The role of ultrasound (US) and magnetic resonance imaging (MRI) in penile fracture mapping for modified surgical repair. Int Urol Nephrol. 2017;49(6):937–45.CrossRef Zare Mehrjardi M, Darabi M, Bagheri SM, Kamali K, Bijan B. The role of ultrasound (US) and magnetic resonance imaging (MRI) in penile fracture mapping for modified surgical repair. Int Urol Nephrol. 2017;49(6):937–45.CrossRef
13.
Zurück zum Zitat Lindquist CM, Nikolaidis P, Mittal PK, Miller FH. MRI of the penis. Abdom Radiol (NY). 2020;45(7):2001–2017 Lindquist CM, Nikolaidis P, Mittal PK, Miller FH. MRI of the penis. Abdom Radiol (NY). 2020;45(7):2001–2017
15.
Zurück zum Zitat De Luca F, Garaffa G, Falcone M, et al. Functional outcomes following immediate repair of penile fracture: a tertiary referral centre experience with 76 consecutive patients. Scand J Urol. 2017;51(2):170–5.CrossRef De Luca F, Garaffa G, Falcone M, et al. Functional outcomes following immediate repair of penile fracture: a tertiary referral centre experience with 76 consecutive patients. Scand J Urol. 2017;51(2):170–5.CrossRef
16.
Zurück zum Zitat Kamdar C, Mooppan UM, Kim H, Gulmi FA. Penile fracture: preoperative evaluation and surgical technique for optimal patient outcome. BJU Int. 2008;102(11):1640–4 discussion 1644.CrossRef Kamdar C, Mooppan UM, Kim H, Gulmi FA. Penile fracture: preoperative evaluation and surgical technique for optimal patient outcome. BJU Int. 2008;102(11):1640–4 discussion 1644.CrossRef
17.
Zurück zum Zitat Mydlo JH, Hayyeri M, Macchia RJ. Urethrography and cavernosography imaging in a small series of penile fractures: a comparison with surgical findings. Urology. 1998;51(4):616–9.CrossRef Mydlo JH, Hayyeri M, Macchia RJ. Urethrography and cavernosography imaging in a small series of penile fractures: a comparison with surgical findings. Urology. 1998;51(4):616–9.CrossRef
18.
Zurück zum Zitat EAU Guidelines. Edn. presented at the EAU Annual Congress, Amsterdam, the Netherlands, 2020. ISBN 978-94-92671-07-3. EAU Guidelines. Edn. presented at the EAU Annual Congress, Amsterdam, the Netherlands, 2020. ISBN 978-94-92671-07-3.
19.
Zurück zum Zitat Rosenstein D, McAninch JW. Urologic emergencies. Med Clin North Am. 2004;88(2):495–518.CrossRef Rosenstein D, McAninch JW. Urologic emergencies. Med Clin North Am. 2004;88(2):495–518.CrossRef
20.
Zurück zum Zitat Creecy AA, Beazlie FS Jr. Fracture of the penis: traumatic rupture of corpora cavernosa. J Urol. 1957;78:620–7.CrossRef Creecy AA, Beazlie FS Jr. Fracture of the penis: traumatic rupture of corpora cavernosa. J Urol. 1957;78:620–7.CrossRef
23.
Zurück zum Zitat • Amer T, Wilson R, Chlosta P, et al. Penile fracture: a meta-analysis. Urol Int. 2016;96(3):315–29 Meta-analysis of outcomes in series of traumatic penile fracture patients.CrossRef • Amer T, Wilson R, Chlosta P, et al. Penile fracture: a meta-analysis. Urol Int. 2016;96(3):315–29 Meta-analysis of outcomes in series of traumatic penile fracture patients.CrossRef
24.
Zurück zum Zitat Al Ansari A, Talib RA, Shamsodini A, Hayati A, Canguven O, Al NA. Which is guilty in self-induced penile fractures: marital status, culture or geographic region? A case series and literature review. Int J Impot Res. 2013;25(6):221–3.CrossRef Al Ansari A, Talib RA, Shamsodini A, Hayati A, Canguven O, Al NA. Which is guilty in self-induced penile fractures: marital status, culture or geographic region? A case series and literature review. Int J Impot Res. 2013;25(6):221–3.CrossRef
25.
Zurück zum Zitat Kozacıoğlu Z, Ceylan Y, Aydoğdu Ö, Bolat D, Günlüsoy B, Minareci S. An update of penile fractures: long-term significance of the number of hours elapsed till surgical repair on long-term outcomes. Turk J Urol. 2017;43(1):25–9.CrossRef Kozacıoğlu Z, Ceylan Y, Aydoğdu Ö, Bolat D, Günlüsoy B, Minareci S. An update of penile fractures: long-term significance of the number of hours elapsed till surgical repair on long-term outcomes. Turk J Urol. 2017;43(1):25–9.CrossRef
30.
Zurück zum Zitat Raheem AA, El-Tatawy H, Eissa A, Elbahnasy AH, Elbendary M. Urinary and sexual functions after surgical treatment of penile fracture concomitant with complete urethral disruption. Arch Ital Urol Androl. 2014;86(1):15–9.CrossRef Raheem AA, El-Tatawy H, Eissa A, Elbahnasy AH, Elbendary M. Urinary and sexual functions after surgical treatment of penile fracture concomitant with complete urethral disruption. Arch Ital Urol Androl. 2014;86(1):15–9.CrossRef
31.
Zurück zum Zitat Acimovic M, Zivkovic M, Georgescu AV, Matei IR, Bumbasirevic U. Repair of urethral injury associated with penile fracture using buccal mucosa graft: a novel therapeutic approach for complex cases. Injury. 2020;s0020-1383(20)30190-X Acimovic M, Zivkovic M, Georgescu AV, Matei IR, Bumbasirevic U. Repair of urethral injury associated with penile fracture using buccal mucosa graft: a novel therapeutic approach for complex cases. Injury. 2020;s0020-1383(20)30190-X
32.
Zurück zum Zitat •• Gelbard M, Goldstein I, Hellstrom WJ, et al. Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of Peyronie’s disease in 2 large double-blind, randomized, placebo controlled phase 3 studies. J Urol. 2013;190(1):199–207 Initial study of CCH treatment leading to FDA approval.CrossRef •• Gelbard M, Goldstein I, Hellstrom WJ, et al. Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of Peyronie’s disease in 2 large double-blind, randomized, placebo controlled phase 3 studies. J Urol. 2013;190(1):199–207 Initial study of CCH treatment leading to FDA approval.CrossRef
34.
Zurück zum Zitat •• Beilan JA, Wallen JJ, Baumgarten AS, Morgan KN, Parker JL, Carrion RE. Intralesional injection of collagenase clostridium histolyticum may increase the risk of late-onset penile fracture. Sex Med Rev. 2018;6(2):272–8 Contributed to new recommendations for prolonged abstinence from sexual activity following CCH therapy.CrossRef •• Beilan JA, Wallen JJ, Baumgarten AS, Morgan KN, Parker JL, Carrion RE. Intralesional injection of collagenase clostridium histolyticum may increase the risk of late-onset penile fracture. Sex Med Rev. 2018;6(2):272–8 Contributed to new recommendations for prolonged abstinence from sexual activity following CCH therapy.CrossRef
35.
Zurück zum Zitat Abdel Raheem A, Capece M, Kalejaiye O, Abdel-Raheem T, Falcone M, Johnson M, et al. Safety and effectiveness of collagenase clostridium histolyticum in the treatment of Peyronie’s disease using a new modified shortened protocol. BJU Int. 2017;120(5):717–23. https://doi.org/10.1111/bju.13932.CrossRefPubMed Abdel Raheem A, Capece M, Kalejaiye O, Abdel-Raheem T, Falcone M, Johnson M, et al. Safety and effectiveness of collagenase clostridium histolyticum in the treatment of Peyronie’s disease using a new modified shortened protocol. BJU Int. 2017;120(5):717–23. https://​doi.​org/​10.​1111/​bju.​13932.CrossRefPubMed
37•.
Zurück zum Zitat ] Yafi FA, Diao L, DeLay KJ, et al. Multi-institutional prospective analysis of intralesional injection of collagenase clostridium histolyticum, tunical plication, and partial plaque excision and grafting for the management of Peyronie’s disease. Urology. 2018;120:138–42. https://doi.org/10.1016/j.urology.2018.06.049Highlights feasibility and risk of surgery for correction of peyronie’s disease following CCH therapy.CrossRefPubMed ] Yafi FA, Diao L, DeLay KJ, et al. Multi-institutional prospective analysis of intralesional injection of collagenase clostridium histolyticum, tunical plication, and partial plaque excision and grafting for the management of Peyronie’s disease. Urology. 2018;120:138–42. https://​doi.​org/​10.​1016/​j.​urology.​2018.​06.​049Highlights feasibility and risk of surgery for correction of peyronie’s disease following CCH therapy.CrossRefPubMed
41.
Zurück zum Zitat Yafi FA, Anaissie J, Zurawin J, Sikka SC, Hellstrom WJ. Results of SMSNA survey regarding complications following intralesional injection therapy with collagenase clostridium histolyticum for Peyronie’s disease. J Sex Med. 2016;13(4):684–9.CrossRef Yafi FA, Anaissie J, Zurawin J, Sikka SC, Hellstrom WJ. Results of SMSNA survey regarding complications following intralesional injection therapy with collagenase clostridium histolyticum for Peyronie’s disease. J Sex Med. 2016;13(4):684–9.CrossRef
42.
Zurück zum Zitat Gelbard M, Lipshultz LI, Tursi J, Smith T, Kaufman G, Levine LA. Phase 2b study of the clinical efficacy and safety of collagenase clostridium histolyticum in patients with Peyronie’s disease. J Urol. 2012;187(6):2268–74.CrossRef Gelbard M, Lipshultz LI, Tursi J, Smith T, Kaufman G, Levine LA. Phase 2b study of the clinical efficacy and safety of collagenase clostridium histolyticum in patients with Peyronie’s disease. J Urol. 2012;187(6):2268–74.CrossRef
47.
Zurück zum Zitat Natale C, McLellan DM, Yousif A, Hellstrom WJG. Review of intralesional collagenase clostridium histolyticum injection therapy and related combination therapies in the treatment of Peyronie's disease (an update) [published online ahead of print, 2020 Mar 18]. Sex Med Rev. 2020;S2050–0521(20):30009–3. https://doi.org/10.1016/j.sxmr.2020.01.005.CrossRef Natale C, McLellan DM, Yousif A, Hellstrom WJG. Review of intralesional collagenase clostridium histolyticum injection therapy and related combination therapies in the treatment of Peyronie's disease (an update) [published online ahead of print, 2020 Mar 18]. Sex Med Rev. 2020;S2050–0521(20):30009–3. https://​doi.​org/​10.​1016/​j.​sxmr.​2020.​01.​005.CrossRef
Metadaten
Titel
The Management of Penile Fracture: a Review of the Literature with Special Consideration for Patients Undergoing Collagenase Clostridium Histolyticum Injection Therapy
verfasst von
William M. Hughes
Caleb Natale
Wayne J. G. Hellstrom
Publikationsdatum
01.02.2021
Verlag
Springer US
Erschienen in
Current Urology Reports / Ausgabe 2/2021
Print ISSN: 1527-2737
Elektronische ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-020-01025-7

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