Erschienen in:
01.06.2010 | SSAT State-of-the-Art Conference
The Molecular Basis of Carcinogenesis in Barrett’s Esophagus
verfasst von:
Rhonda F. Souza
Erschienen in:
Journal of Gastrointestinal Surgery
|
Ausgabe 6/2010
Einloggen, um Zugang zu erhalten
Excerpt
Our current management of cancer risk in Barrett’s esophagus is to perform endoscopic surveillance for the detection of dysplasia. However, dysplasia is an imperfect predictor of cancer risk for a variety of reasons including biopsy sampling error, poor intra- and inter-observer reproducibility of dysplasia interpretations and the poor predictive value for negative, indefinite, low-grade, and even high-grade dysplasia.
1‐
3 Dysplasia is a conglomerate of histologic abnormalities that suggest that clones of cells have acquired neoplastic properties that predispose them to cancer formation. Therefore, dysplasia is a surrogate marker for cells that have accumulated enough genetic damage that they now possess some of the physiologic properties of cancer cells. Therefore, a better indicator of cancer risk would be detection of the genetic damage itself before the histologic manifestations of dysplasia are even apparent. In addition, the identification of molecular biomarkers may offer easy reproducibility and standardization in addition to the truly early detection of neoplastic progression. …
