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30.09.2023 | Original Article

The prognostic nutrition index is a predictor for long-term outcomes after revascularization in adult moyamoya disease

verfasst von: Xiaofan Yu, Peicong Ge, Yuanren Zhai, Wei Liu, Qian Zhang, Xun Ye, Xingju Liu, Rong Wang, Yan Zhang, Jizong Zhao, Dong Zhang

Erschienen in: Acta Neurochirurgica | Ausgabe 12/2023

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Abstract

Background and purpose

The prognostic nutrition index (PNI) has been associated with the prognosis of various medical disorders. This study aimed to explore the correlation between PNI and the long-term outcomes of adult patients afflicted with moyamoya disease (MMD).

Methods

This prospective study initially employed 138 adult patients diagnosed with MMD. After excluding 15 patients who did not meet the criteria, a total of 123 patients were included. Participants were divided into three groups based on the tertile of change in the PNI score. Statistical analysis compared clinical information and lab tests among the groups. The study was conducted between July 1 and December 31, 2019.

Results

After adjusting for multiple variables, patients in the upper two tertiles (tertiles 2–3) exhibited a significantly lower risk of adverse long-term outcomes compared to those in the lowest tertile (tertile 1) (OR, 0.089; 95% CI, 0.009–0.895; P = 0.040). Furthermore, adding PNI tertile to traditional risk factors substantially improved predicting adverse long-term outcomes (net reclassification improvement: 98.03%, P = 0.000; integrated discrimination improvement: 4.65%, P = 0.030). However, there was no statistically significant difference between the first PNI tertile (tertile 1) and the upper two tertiles (tertiles 2–3) in the Kaplan–Meier curve of stroke incidence (log-rank test, P = 0.244).

Conclusions

A higher PNI level was significantly associated with a reduced risk of unfavorable long-term outcomes. Nevertheless, the PNI score did not predict stroke recurrence during extended follow-up. This study provides insights into a potential predictor of adverse long-term outcomes after revascularization in MMD patients.

Registration number

ChiCTR2000031412

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Titel: The prognostic nutrition index is a predictor for long-term outcomes after revascularization in adult moyamoya disease
verfasst von: Xiaofan Yu
Peicong Ge
Yuanren Zhai
Wei Liu
Qian Zhang
Xun Ye
Xingju Liu
Rong Wang
Yan Zhang
Jizong Zhao
Dong Zhang
Publikationsdatum: 30.09.2023
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 12/2023
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-023-05816-y

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The prognostic nutrition index is a predictor for long-term outcomes after revascularization in adult moyamoya disease