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28.11.2021 | Review

The pros and cons of cytokines for fowl adenovirus serotype 4 infection

verfasst von: Baiyu Wang, Huifang Guo, Jun Zhao

Erschienen in: Archives of Virology | Ausgabe 2/2022

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Abstract

Hepatitis-hydropericardium syndrome (HHS), caused by fowl adenovirus serotype 4 (FAdV-4), has spread on chicken farms worldwide, causing huge economic losses. Currently, the exact mechanism of pathogenesis of FAdV-4 remains unknown. Despite the severe inflammatory damage observed in chickens infected with pathogenic FAdV-4, few studies have focused on the host immune system-virus interactions and cytokine secretion. Host immunity acts as one of the most robust defense mechanisms against infection by pathogens, and cytokines are important in their elimination. However, excessive inflammatory cytokine secretion could contribute to the pathogenesis of FAdV-4. Understanding of the roles of cytokines produced during FAdV-4 infection is important for the study of pathogenicity and for developing strategies to control FAdV-4. Several previous studies have addressed the immune responses to FAdV-4 infection, but there has not been a systematic review of this work. The present review provides a detailed summary of the current findings on cytokine production induced by FAdV-4 infection to accelerate our understanding of FAdV-4 pathogenesis.

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Titel: The pros and cons of cytokines for fowl adenovirus serotype 4 infection
verfasst von: Baiyu Wang
Huifang Guo
Jun Zhao
Publikationsdatum: 28.11.2021
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 2/2022
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-021-05318-1

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