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Erschienen in: Current Infectious Disease Reports 6/2015

01.06.2015 | Healthcare Associated Infections (G Bearman and D Morgan, Section Editors)

The Pros, Cons, and Unknowns of Search and Destroy for Carbapenem-Resistant Enterobacteriaceae

verfasst von: Prashini Moodley, Andrew Whitelaw

Erschienen in: Current Infectious Disease Reports | Ausgabe 6/2015

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Abstract

Antibiotic drug discovery has not kept pace with the development of microbial resistance to these agents. There are ever increasing reports where the causative agents of serious infections are multi-drug resistant and in some cases resistant to all known antibiotics. The emergence and spread of carbapenemase-producing Enterobacteriaceae has heightened awareness regarding antibiotic stewardship programs and infection prevention and control measures. There has been much controversy regarding the utility of the “search and destroy” strategy to prevent the spread of carbapenem-resistant Enterobacteriaceae. These controversies center on screening and management of carriers, including decontamination and isolation. It is however clear that a functional infection prevention and control program is fundamental to any strategy that serves to address the spread of microbes within a healthcare facility.
Literatur
2.
Zurück zum Zitat Livermore DM. Antibiotic resistance in staphylococci. Int J Antimicrob Agents. 2000;16 Suppl 1:S3–10.CrossRefPubMed Livermore DM. Antibiotic resistance in staphylococci. Int J Antimicrob Agents. 2000;16 Suppl 1:S3–10.CrossRefPubMed
3.
Zurück zum Zitat Ferebee SH. Controlled chemoprophylaxis trials in tuberculosis. A general review. Bibl Tuberc. 1970;26:28–106.PubMed Ferebee SH. Controlled chemoprophylaxis trials in tuberculosis. A general review. Bibl Tuberc. 1970;26:28–106.PubMed
4.
Zurück zum Zitat Kock R, Becker K, Cookson B, van Gemert-Pijnen JE, Harbarth S, Kluytmans J, et al. Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe. Euro Surveill: Bull Eur sur les Maladies Transmissibles = Eur Communicable Dis Bull. 2010;15(41):19688. Kock R, Becker K, Cookson B, van Gemert-Pijnen JE, Harbarth S, Kluytmans J, et al. Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe. Euro Surveill: Bull Eur sur les Maladies Transmissibles = Eur Communicable Dis Bull. 2010;15(41):19688.
5.
Zurück zum Zitat Boyce JM, Suppl A. MRSA patients: proven methods to treat colonization and infection. J Hosp Infect. 2001;48:S9–14.CrossRefPubMed Boyce JM, Suppl A. MRSA patients: proven methods to treat colonization and infection. J Hosp Infect. 2001;48:S9–14.CrossRefPubMed
6.
Zurück zum Zitat Boyce JM, Jackson MM, Pugliese G, Batt MD, Fleming D, Garner JS, et al. Methicillin-resistant Staphylococcus aureus (MRSA): a briefing for acute care hospitals and nursing facilities. The AHA technical panel on infections within hospitals. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 1994;15(2):105–15.CrossRef Boyce JM, Jackson MM, Pugliese G, Batt MD, Fleming D, Garner JS, et al. Methicillin-resistant Staphylococcus aureus (MRSA): a briefing for acute care hospitals and nursing facilities. The AHA technical panel on infections within hospitals. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 1994;15(2):105–15.CrossRef
7.
Zurück zum Zitat Ribeiro J, Boyce JM, Zancanaro PQ. Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) among patients visiting the emergency room at a tertiary hospital in Brazil. Braz J Infect Dis: Off Publ Braz Soc Infect Dis. 2005;9(1):52–5.CrossRef Ribeiro J, Boyce JM, Zancanaro PQ. Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) among patients visiting the emergency room at a tertiary hospital in Brazil. Braz J Infect Dis: Off Publ Braz Soc Infect Dis. 2005;9(1):52–5.CrossRef
8.
Zurück zum Zitat Abecasis F, Kerr S, Sarginson RE, Silvestri L, de la Cal MA, Zandstra D, et al. Comment on: emergence of multidrug-resistant Gram-negative bacteria during selective decontamination of the digestive tract on an intensive care unit. J Antimicrob Chemother. 2007;60(2):445. author reply 446.CrossRefPubMed Abecasis F, Kerr S, Sarginson RE, Silvestri L, de la Cal MA, Zandstra D, et al. Comment on: emergence of multidrug-resistant Gram-negative bacteria during selective decontamination of the digestive tract on an intensive care unit. J Antimicrob Chemother. 2007;60(2):445. author reply 446.CrossRefPubMed
9.
Zurück zum Zitat Petros A, Roos D, van Saene H, Taylor N, Rommes H, Silvestri L. Selective decontamination of the digestive tract may reduce perioperative risk in elective surgery. BMJ. 2011;343:d7536. author reply 7542.CrossRefPubMed Petros A, Roos D, van Saene H, Taylor N, Rommes H, Silvestri L. Selective decontamination of the digestive tract may reduce perioperative risk in elective surgery. BMJ. 2011;343:d7536. author reply 7542.CrossRefPubMed
10.
Zurück zum Zitat Petros AJ, Silvestri L, Taylor N, Abecasis F, Damjanovic V, de la Cal MA, et al. Comment on: Selective decontamination of the oropharynx and the digestive tract, and antimicrobial resistance: a 4 year ecological study in 38 intensive care units in the Netherlands. J Antimicrob Chemother. 2014;69(3):860.CrossRefPubMed Petros AJ, Silvestri L, Taylor N, Abecasis F, Damjanovic V, de la Cal MA, et al. Comment on: Selective decontamination of the oropharynx and the digestive tract, and antimicrobial resistance: a 4 year ecological study in 38 intensive care units in the Netherlands. J Antimicrob Chemother. 2014;69(3):860.CrossRefPubMed
11.
Zurück zum Zitat Silvestri L, de la Cal MA, Taylor N, van Saene HK, Parodi PC. Selective decontamination of the digestive tract in burn patients: an evidence-based maneuver that reduces mortality. J Burn Care Res: Off Publ Am Burn Assoc. 2010;31(2):372–3. author reply 374.CrossRef Silvestri L, de la Cal MA, Taylor N, van Saene HK, Parodi PC. Selective decontamination of the digestive tract in burn patients: an evidence-based maneuver that reduces mortality. J Burn Care Res: Off Publ Am Burn Assoc. 2010;31(2):372–3. author reply 374.CrossRef
12.
Zurück zum Zitat Silvestri L, Mannucci F, van Saene HK. Selective decontamination of the digestive tract: a life saver. J Hosp Infect. 2000;45(3):185–90.CrossRefPubMed Silvestri L, Mannucci F, van Saene HK. Selective decontamination of the digestive tract: a life saver. J Hosp Infect. 2000;45(3):185–90.CrossRefPubMed
13.
Zurück zum Zitat Silvestri L, Petros AJ, Viviani M, Rommes JH, van Saene HK. Selective decontamination of the digestive tract and ventilator-associated pneumonia (part 1). Respir Care. 2006;51(1):67–9. author reply 70–62.PubMed Silvestri L, Petros AJ, Viviani M, Rommes JH, van Saene HK. Selective decontamination of the digestive tract and ventilator-associated pneumonia (part 1). Respir Care. 2006;51(1):67–9. author reply 70–62.PubMed
14.
Zurück zum Zitat Silvestri L, van Saene HK. Selective decontamination of the digestive tract does not increase resistance in critically ill patients: evidence from randomized controlled trials. Crit Care Med. 2006;34(7):2027–9. author reply 2029–2030.CrossRefPubMed Silvestri L, van Saene HK. Selective decontamination of the digestive tract does not increase resistance in critically ill patients: evidence from randomized controlled trials. Crit Care Med. 2006;34(7):2027–9. author reply 2029–2030.CrossRefPubMed
15.
Zurück zum Zitat Silvestri L, van Saene HK, de la Cal MA, Sarginson RE, Thomann C. Prevention of ventilator-associated pneumonia by selective decontamination of the digestive tract. Eur Respir J. 2008;32(1):241–3.CrossRefPubMed Silvestri L, van Saene HK, de la Cal MA, Sarginson RE, Thomann C. Prevention of ventilator-associated pneumonia by selective decontamination of the digestive tract. Eur Respir J. 2008;32(1):241–3.CrossRefPubMed
16.
Zurück zum Zitat Silvestri L, van Saene HK, Milanese M, Gregori D, Gullo A. Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials. J Hosp Infect. 2007;65(3):187–203.CrossRefPubMed Silvestri L, van Saene HK, Milanese M, Gregori D, Gullo A. Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials. J Hosp Infect. 2007;65(3):187–203.CrossRefPubMed
17.
Zurück zum Zitat Silvestri L, van Saene HK, Petros AJ. Selective digestive tract decontamination in critically ill patients. Expert Opin Pharmacother. 2012;13(8):1113–29.CrossRefPubMed Silvestri L, van Saene HK, Petros AJ. Selective digestive tract decontamination in critically ill patients. Expert Opin Pharmacother. 2012;13(8):1113–29.CrossRefPubMed
18.
Zurück zum Zitat van Saene HK, Damjanovic V, Silvestri L, de la Cal MA, Zandstra DF. Selective decontamination of the digestive tract and ventilator-associated pneumonia (part 2). Respir Care. 2006;51(1):72–5. author reply 75.PubMed van Saene HK, Damjanovic V, Silvestri L, de la Cal MA, Zandstra DF. Selective decontamination of the digestive tract and ventilator-associated pneumonia (part 2). Respir Care. 2006;51(1):72–5. author reply 75.PubMed
19.
Zurück zum Zitat Petros A, Silvestri L, Booth R, Taylor N, van Saene H. Selective decontamination of the digestive tract in critically ill children: systematic review and meta-analysis. Pediatr Crit Care Med: J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc. 2013;14(1):89–97.CrossRef Petros A, Silvestri L, Booth R, Taylor N, van Saene H. Selective decontamination of the digestive tract in critically ill children: systematic review and meta-analysis. Pediatr Crit Care Med: J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc. 2013;14(1):89–97.CrossRef
20.
Zurück zum Zitat Zandstra DF, Petros AJ, Silvestri L, de la Cal MA, Taylor N, Damjanovic V, et al. Selective decontamination of the digestive tract: selectivity is not required. Intensive Care Med. 2010;36(10):1783–4.CrossRefPubMedCentralPubMed Zandstra DF, Petros AJ, Silvestri L, de la Cal MA, Taylor N, Damjanovic V, et al. Selective decontamination of the digestive tract: selectivity is not required. Intensive Care Med. 2010;36(10):1783–4.CrossRefPubMedCentralPubMed
21.
Zurück zum Zitat Zandstra DF, Petros AJ, Taylor N, Silvestri L, de la Cal MA, van Saene HK. Withholding selective decontamination of the digestive tract from critically ill patients must now surely be ethically questionable given the vast evidence base. Crit Care. 2010;14(5):443.CrossRefPubMedCentralPubMed Zandstra DF, Petros AJ, Taylor N, Silvestri L, de la Cal MA, van Saene HK. Withholding selective decontamination of the digestive tract from critically ill patients must now surely be ethically questionable given the vast evidence base. Crit Care. 2010;14(5):443.CrossRefPubMedCentralPubMed
22.
Zurück zum Zitat Petros AJ, Silvestri L, van Saene HK, Zandstra DF, de la Cal MA, Viviani M, et al. 2B or not 2B for selective decontamination of the digestive tract in the surviving sepsis campaign guidelines. Crit Care Med. 2013;41(11):e385–6.CrossRefPubMed Petros AJ, Silvestri L, van Saene HK, Zandstra DF, de la Cal MA, Viviani M, et al. 2B or not 2B for selective decontamination of the digestive tract in the surviving sepsis campaign guidelines. Crit Care Med. 2013;41(11):e385–6.CrossRefPubMed
23.
Zurück zum Zitat Kollef MH, Micek ST. Rational use of antibiotics in the ICU: balancing stewardship and clinical outcomes. JAMA. 2014;312(14):1403–4.CrossRefPubMed Kollef MH, Micek ST. Rational use of antibiotics in the ICU: balancing stewardship and clinical outcomes. JAMA. 2014;312(14):1403–4.CrossRefPubMed
24.
Zurück zum Zitat Guh AY, Limbago BM, Kallen AJ. Epidemiology and prevention of carbapenem-resistant Enterobacteriaceae in the United States. Expert Rev Anti-Infect Ther. 2014;12(5):565–80.CrossRefPubMed Guh AY, Limbago BM, Kallen AJ. Epidemiology and prevention of carbapenem-resistant Enterobacteriaceae in the United States. Expert Rev Anti-Infect Ther. 2014;12(5):565–80.CrossRefPubMed
25.
Zurück zum Zitat Gupta N, Limbago BM, Patel JB, Kallen AJ. Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis: Off Publ Infect Dis Soc Am. 2011;53(1):60–7.CrossRef Gupta N, Limbago BM, Patel JB, Kallen AJ. Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis: Off Publ Infect Dis Soc Am. 2011;53(1):60–7.CrossRef
26.
Zurück zum Zitat Williams RJ. Epidemiology of antibiotic resistance in gram-negative bacteria. J Hosp Infect. 1988;11(Suppl A):130–4.CrossRefPubMed Williams RJ. Epidemiology of antibiotic resistance in gram-negative bacteria. J Hosp Infect. 1988;11(Suppl A):130–4.CrossRefPubMed
27.
Zurück zum Zitat Williams RJ, Heymann DL. Containment of antibiotic resistance. Science. 1998;279(5354):1153–4.CrossRefPubMed Williams RJ, Heymann DL. Containment of antibiotic resistance. Science. 1998;279(5354):1153–4.CrossRefPubMed
28.
Zurück zum Zitat Williams RJ, Lindridge MA, Said AA, Livermore DM, Williams JD. National survey of antibiotic resistance in Pseudomonas aeruginosa. J Antimicrob Chemother. 1984;14(1):9–16.CrossRefPubMed Williams RJ, Lindridge MA, Said AA, Livermore DM, Williams JD. National survey of antibiotic resistance in Pseudomonas aeruginosa. J Antimicrob Chemother. 1984;14(1):9–16.CrossRefPubMed
29.
Zurück zum Zitat Yang YJ, Livermore DM, Williams RJ. Chromosomal beta-lactamase expression and antibiotic resistance in Enterobacter cloacae. J Med Microbiol. 1988;25(3):227–33.CrossRefPubMed Yang YJ, Livermore DM, Williams RJ. Chromosomal beta-lactamase expression and antibiotic resistance in Enterobacter cloacae. J Med Microbiol. 1988;25(3):227–33.CrossRefPubMed
30.
Zurück zum Zitat Kim NH, Han WD, Song KH, Seo HK, Shin MJ, Kim TS, et al. Successful containment of carbapenem-resistant Enterobacteriaceae by strict contact precautions without active surveillance. Am J Infect Control. 2014;42(12):1270–3.CrossRefPubMed Kim NH, Han WD, Song KH, Seo HK, Shin MJ, Kim TS, et al. Successful containment of carbapenem-resistant Enterobacteriaceae by strict contact precautions without active surveillance. Am J Infect Control. 2014;42(12):1270–3.CrossRefPubMed
31.
Zurück zum Zitat Barbarini D, Russello G, Brovarone F, Capatti C, Colla R, Perilli M, et al. Evaluation of carbapenem-resistant Enterobacteriaceae in an Italian setting: report from the trench. Infect Gen Evol: J Mol Epidemiol Evol Gen Infect Dis. 2014;30C:8–14. Barbarini D, Russello G, Brovarone F, Capatti C, Colla R, Perilli M, et al. Evaluation of carbapenem-resistant Enterobacteriaceae in an Italian setting: report from the trench. Infect Gen Evol: J Mol Epidemiol Evol Gen Infect Dis. 2014;30C:8–14.
32.
Zurück zum Zitat Muscarella LF. Risk of transmission of carbapenem-resistant Enterobacteriaceae and related “superbugs” during gastrointestinal endoscopy. World J Gastrointest Endosc. 2014;6(10):457–74.CrossRefPubMedCentralPubMed Muscarella LF. Risk of transmission of carbapenem-resistant Enterobacteriaceae and related “superbugs” during gastrointestinal endoscopy. World J Gastrointest Endosc. 2014;6(10):457–74.CrossRefPubMedCentralPubMed
33.
Zurück zum Zitat Zurawski RM. Carbapenem-resistant enterobacteriaceae: occult threat in the intensive care unit. Crit Care Nurse. 2014;34(5):44–52.CrossRefPubMed Zurawski RM. Carbapenem-resistant enterobacteriaceae: occult threat in the intensive care unit. Crit Care Nurse. 2014;34(5):44–52.CrossRefPubMed
34.
Zurück zum Zitat Rafailidis PI, Falagas ME. Options for treating carbapenem-resistant Enterobacteriaceae. Curr Opin Infect Dis. 2014;27(6):479–83.CrossRefPubMed Rafailidis PI, Falagas ME. Options for treating carbapenem-resistant Enterobacteriaceae. Curr Opin Infect Dis. 2014;27(6):479–83.CrossRefPubMed
35.
Zurück zum Zitat Temkin E, Adler A, Lerner A, Carmeli Y. Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management. Ann N Y Acad Sci. 2014;1323:22–42.CrossRefPubMed Temkin E, Adler A, Lerner A, Carmeli Y. Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management. Ann N Y Acad Sci. 2014;1323:22–42.CrossRefPubMed
36.
Zurück zum Zitat Hsieh WS, Wang NY, Feng JA, Weng LC, Wu HH. Molecular surveillance and prevalence of carbapenem-resistant Enterobacteriaceae in northern Taiwan. J Antimicrob Chemother. 2014;69(10):2871–3.CrossRefPubMed Hsieh WS, Wang NY, Feng JA, Weng LC, Wu HH. Molecular surveillance and prevalence of carbapenem-resistant Enterobacteriaceae in northern Taiwan. J Antimicrob Chemother. 2014;69(10):2871–3.CrossRefPubMed
37.
Zurück zum Zitat Yamamoto M, Pop-Vicas AE. Treatment for infections with carbapenem-resistant Enterobacteriaceae: what options do we still have? Crit Care. 2014;18(3):229.CrossRefPubMed Yamamoto M, Pop-Vicas AE. Treatment for infections with carbapenem-resistant Enterobacteriaceae: what options do we still have? Crit Care. 2014;18(3):229.CrossRefPubMed
38.
Zurück zum Zitat Thaden JT, Lewis SS, Hazen KC, Huslage K, Fowler Jr VG, Moehring RW, et al. Rising rates of carbapenem-resistant Enterobacteriaceae in community hospitals: a mixed-methods review of epidemiology and microbiology practices in a network of community hospitals in the southeastern United States. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(8):978–83.CrossRef Thaden JT, Lewis SS, Hazen KC, Huslage K, Fowler Jr VG, Moehring RW, et al. Rising rates of carbapenem-resistant Enterobacteriaceae in community hospitals: a mixed-methods review of epidemiology and microbiology practices in a network of community hospitals in the southeastern United States. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(8):978–83.CrossRef
39.
Zurück zum Zitat Falagas ME, Tansarli GS, Karageorgopoulos DE, Vardakas KZ. Deaths attributable to carbapenem-resistant Enterobacteriaceae infections. Emerg Infect Dis. 2014;20(7):1170–5.CrossRefPubMedCentralPubMed Falagas ME, Tansarli GS, Karageorgopoulos DE, Vardakas KZ. Deaths attributable to carbapenem-resistant Enterobacteriaceae infections. Emerg Infect Dis. 2014;20(7):1170–5.CrossRefPubMedCentralPubMed
40.
Zurück zum Zitat Palmore TN, Henderson DK. Carbapenem-resistant Enterobacteriaceae: a call for cultural change. Ann Intern Med. 2014;160(8):567–9.CrossRefPubMed Palmore TN, Henderson DK. Carbapenem-resistant Enterobacteriaceae: a call for cultural change. Ann Intern Med. 2014;160(8):567–9.CrossRefPubMed
41.
Zurück zum Zitat Dirajlal-Fargo S, DeBiasi R, Campos J, Song X. Carbapenem-resistant Enterobacteriaceae in pediatric patients: epidemiology and risk factors. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):447–9.CrossRef Dirajlal-Fargo S, DeBiasi R, Campos J, Song X. Carbapenem-resistant Enterobacteriaceae in pediatric patients: epidemiology and risk factors. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):447–9.CrossRef
42.
Zurück zum Zitat Drekonja DM, Beekmann SE, Elliott S, Mukundan D, Polenakovik H, Rosenthal ME, et al. Challenges in the management of infections due to carbapenem-resistant Enterobacteriaceae. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):437–9.CrossRef Drekonja DM, Beekmann SE, Elliott S, Mukundan D, Polenakovik H, Rosenthal ME, et al. Challenges in the management of infections due to carbapenem-resistant Enterobacteriaceae. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):437–9.CrossRef
43.
Zurück zum Zitat Pisney LM, Barron MA, Kassner E, Havens D, Madinger NE. Carbapenem-resistant Enterobacteriaceae rectal screening during an outbreak of New Delhi metallo-beta-lactamase-producing Klebsiella pneumoniae at an acute care hospital. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):434–6.CrossRef Pisney LM, Barron MA, Kassner E, Havens D, Madinger NE. Carbapenem-resistant Enterobacteriaceae rectal screening during an outbreak of New Delhi metallo-beta-lactamase-producing Klebsiella pneumoniae at an acute care hospital. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):434–6.CrossRef
44.
Zurück zum Zitat Fitzpatrick M, Zembower T, Malczynski M, Qi C, Bolon MK. Outcomes of an enhanced surveillance program for carbapenem-resistant Enterobacteriaceae. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):419–22.CrossRef Fitzpatrick M, Zembower T, Malczynski M, Qi C, Bolon MK. Outcomes of an enhanced surveillance program for carbapenem-resistant Enterobacteriaceae. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):419–22.CrossRef
45.
Zurück zum Zitat Landry J, Hurst H. The emerging threat from carbapenem-resistant enterobacteriaceae. NursWomens Health. 2013;17(6):519–24. Landry J, Hurst H. The emerging threat from carbapenem-resistant enterobacteriaceae. NursWomens Health. 2013;17(6):519–24.
46.
Zurück zum Zitat Johnson K, Boucher HW. Editorial commentary: imminent challenges: carbapenem-resistant Enterobacteriaceae in transplant recipients and patients with hematologic malignancy. Clin Infect Dis: Off Publ Infect Dis Soc Am. 2014;58(9):1284–6.CrossRef Johnson K, Boucher HW. Editorial commentary: imminent challenges: carbapenem-resistant Enterobacteriaceae in transplant recipients and patients with hematologic malignancy. Clin Infect Dis: Off Publ Infect Dis Soc Am. 2014;58(9):1284–6.CrossRef
47.•
Zurück zum Zitat Schwaber MJ, Carmeli Y. An ongoing national intervention to contain the spread of carbapenem-resistant Enterobacteriaceae. Clin Infect Dis: Off Publ Infect Dis Soc Am. 2014;58(5):697–703. This study demonstrates the results that can be obtained through a nationally co-ordinated response to the challenge of CRE.CrossRef Schwaber MJ, Carmeli Y. An ongoing national intervention to contain the spread of carbapenem-resistant Enterobacteriaceae. Clin Infect Dis: Off Publ Infect Dis Soc Am. 2014;58(5):697–703. This study demonstrates the results that can be obtained through a nationally co-ordinated response to the challenge of CRE.CrossRef
48.
Zurück zum Zitat Kruse EB, Aurbach U, Wisplinghoff H. Carbapenem-resistant Enterobacteriaceae: laboratory detection and infection control practices. Curr Infect Dis Rep. 2013. Kruse EB, Aurbach U, Wisplinghoff H. Carbapenem-resistant Enterobacteriaceae: laboratory detection and infection control practices. Curr Infect Dis Rep. 2013.
49.
Zurück zum Zitat Palmore TN, Henderson DK. Managing transmission of carbapenem-resistant Enterobacteriaceae in healthcare settings: a view from the trenches. Clin Infect Dis: Off Publ Infect Dis Soc Am. 2013;57(11):1593–9.CrossRef Palmore TN, Henderson DK. Managing transmission of carbapenem-resistant Enterobacteriaceae in healthcare settings: a view from the trenches. Clin Infect Dis: Off Publ Infect Dis Soc Am. 2013;57(11):1593–9.CrossRef
50.
Zurück zum Zitat Arend LN, Pilonetto M, de Alencar Siebra C, Tuon FF. Phenotypic and molecular characterization of 942 carbapenem-resistant Enterobacteriaceae (CRE) in southern Brazil. J Infect Chemother: Off J Jpn Soc Chemother. 2014. Arend LN, Pilonetto M, de Alencar Siebra C, Tuon FF. Phenotypic and molecular characterization of 942 carbapenem-resistant Enterobacteriaceae (CRE) in southern Brazil. J Infect Chemother: Off J Jpn Soc Chemother. 2014.
51.
Zurück zum Zitat Banach DB, Francois J, Blash S, Patel G, Jenkins SG, LaBombardi V, et al. Active surveillance for carbapenem-resistant Enterobacteriaceae using stool specimens submitted for testing for Clostridium difficile. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(1):82–4.CrossRef Banach DB, Francois J, Blash S, Patel G, Jenkins SG, LaBombardi V, et al. Active surveillance for carbapenem-resistant Enterobacteriaceae using stool specimens submitted for testing for Clostridium difficile. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(1):82–4.CrossRef
52.
Zurück zum Zitat Betts JW, Phee LM, Hornsey M, Woodford N, Wareham DW. In vitro and in vivo activities of tigecycline-colistin combination therapies against carbapenem-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2014;58(6):3541–6.CrossRefPubMedCentralPubMed Betts JW, Phee LM, Hornsey M, Woodford N, Wareham DW. In vitro and in vivo activities of tigecycline-colistin combination therapies against carbapenem-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2014;58(6):3541–6.CrossRefPubMedCentralPubMed
53.
Zurück zum Zitat Birgy A, Bidet P, Genel N, Doit C, Decre D, Arlet G, et al. Phenotypic screening of carbapenemases and associated beta-lactamases in carbapenem-resistant Enterobacteriaceae. J Clin Microbiol. 2012;50(4):1295–302.CrossRefPubMedCentralPubMed Birgy A, Bidet P, Genel N, Doit C, Decre D, Arlet G, et al. Phenotypic screening of carbapenemases and associated beta-lactamases in carbapenem-resistant Enterobacteriaceae. J Clin Microbiol. 2012;50(4):1295–302.CrossRefPubMedCentralPubMed
54.
Zurück zum Zitat Boyce JM, Havill NL. Comparison of BD GeneOhm methicillin-resistant Staphylococcus aureus (MRSA) PCR versus the CHROMagar MRSA assay for screening patients for the presence of MRSA strains. J Clin Microbiol. 2008;46(1):350–1.CrossRefPubMedCentralPubMed Boyce JM, Havill NL. Comparison of BD GeneOhm methicillin-resistant Staphylococcus aureus (MRSA) PCR versus the CHROMagar MRSA assay for screening patients for the presence of MRSA strains. J Clin Microbiol. 2008;46(1):350–1.CrossRefPubMedCentralPubMed
55.
Zurück zum Zitat Havill NL, Boyce JM. Evaluation of a new selective medium, BD BBL CHROMagar MRSA II, for detection of methicillin-resistant Staphylococcus aureus in stool specimens. J Clin Microbiol. 2010;48(6):2228–30.CrossRefPubMedCentralPubMed Havill NL, Boyce JM. Evaluation of a new selective medium, BD BBL CHROMagar MRSA II, for detection of methicillin-resistant Staphylococcus aureus in stool specimens. J Clin Microbiol. 2010;48(6):2228–30.CrossRefPubMedCentralPubMed
56.
Zurück zum Zitat Kazi M, Drego L, Nikam C, Ajbani K, Soman R, Shetty A, Rodrigues C. Molecular characterization of carbapenem-resistant Enterobacteriaceae at a tertiary care laboratory in Mumbai. Eur J Clin Microbiol Infect Dis: Off Publ Eur Soc Clin Microbiol. 2014. Kazi M, Drego L, Nikam C, Ajbani K, Soman R, Shetty A, Rodrigues C. Molecular characterization of carbapenem-resistant Enterobacteriaceae at a tertiary care laboratory in Mumbai. Eur J Clin Microbiol Infect Dis: Off Publ Eur Soc Clin Microbiol. 2014.
57.
Zurück zum Zitat Kim J, Lee JY, Kim SI, Song W, Kim JS, Jung S, et al. Rates of fecal transmission of extended-spectrum beta-lactamase-producing and carbapenem-resistant Enterobacteriaceae among patients in intensive care units in Korea. Ann Lab Med. 2014;34(1):20–5.CrossRefPubMedCentralPubMed Kim J, Lee JY, Kim SI, Song W, Kim JS, Jung S, et al. Rates of fecal transmission of extended-spectrum beta-lactamase-producing and carbapenem-resistant Enterobacteriaceae among patients in intensive care units in Korea. Ann Lab Med. 2014;34(1):20–5.CrossRefPubMedCentralPubMed
58.
Zurück zum Zitat Lerner A, Romano J, Chmelnitsky I, Navon-Venezia S, Edgar R, Carmeli Y. Rectal swabs are suitable for quantifying the carriage load of KPC-producing carbapenem-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2013;57(3):1474–9.CrossRefPubMedCentralPubMed Lerner A, Romano J, Chmelnitsky I, Navon-Venezia S, Edgar R, Carmeli Y. Rectal swabs are suitable for quantifying the carriage load of KPC-producing carbapenem-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2013;57(3):1474–9.CrossRefPubMedCentralPubMed
59.
Zurück zum Zitat Michalska AD, Sacha PT, Ojdana D, Majewski P, Wieczorek P, Tryniszewska E. Carbapenem-resistant strains from the family Enterobacteriaceae isolated in the period 2006–2011 from clinical specimens of patients treated at the university hospital in northeastern Poland. Medycyna Doswiadczalna i Mikrobiologia. 2013;65(1):27–38.PubMed Michalska AD, Sacha PT, Ojdana D, Majewski P, Wieczorek P, Tryniszewska E. Carbapenem-resistant strains from the family Enterobacteriaceae isolated in the period 2006–2011 from clinical specimens of patients treated at the university hospital in northeastern Poland. Medycyna Doswiadczalna i Mikrobiologia. 2013;65(1):27–38.PubMed
60.
Zurück zum Zitat Pereira EC, Shaw KM, Vagnone PM, Harper JE, Kallen AJ, Limbago BM, et al. Thirty-day laboratory-based surveillance for carbapenem-resistant Enterobacteriaceae in the Minneapolis-St. Paul Metropolitan Area Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):423–5.CrossRef Pereira EC, Shaw KM, Vagnone PM, Harper JE, Kallen AJ, Limbago BM, et al. Thirty-day laboratory-based surveillance for carbapenem-resistant Enterobacteriaceae in the Minneapolis-St. Paul Metropolitan Area Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):423–5.CrossRef
61.
Zurück zum Zitat Pollett S, Miller S, Hindler J, Uslan D, Carvalho M, Humphries RM. Phenotypic and molecular characteristics of carbapenem-resistant Enterobacteriaceae in a health care system in Los Angeles, California, from 2011 to 2013. J Clin Microbiol. 2014;52(11):4003–9.CrossRefPubMedCentralPubMed Pollett S, Miller S, Hindler J, Uslan D, Carvalho M, Humphries RM. Phenotypic and molecular characteristics of carbapenem-resistant Enterobacteriaceae in a health care system in Los Angeles, California, from 2011 to 2013. J Clin Microbiol. 2014;52(11):4003–9.CrossRefPubMedCentralPubMed
62.
Zurück zum Zitat Samra Z, Bahar J, Madar-Shapiro L, Aziz N, Israel S, Bishara J. Evaluation of CHROMagar KPC for rapid detection of carbapenem-resistant Enterobacteriaceae. J Clin Microbiol. 2008;46(9):3110–1.CrossRefPubMedCentralPubMed Samra Z, Bahar J, Madar-Shapiro L, Aziz N, Israel S, Bishara J. Evaluation of CHROMagar KPC for rapid detection of carbapenem-resistant Enterobacteriaceae. J Clin Microbiol. 2008;46(9):3110–1.CrossRefPubMedCentralPubMed
63.
Zurück zum Zitat Schechner V, Kotlovsky T, Tarabeia J, Kazma M, Schwartz D, Navon-Venezia S, et al. Predictors of rectal carriage of carbapenem-resistant Enterobacteriaceae (CRE) among patients with known CRE carriage at their next hospital encounter. Infect Control Hosp Epidemiol: Official J Soc Hosp Epidemiol Am. 2011;32(5):497–503.CrossRef Schechner V, Kotlovsky T, Tarabeia J, Kazma M, Schwartz D, Navon-Venezia S, et al. Predictors of rectal carriage of carbapenem-resistant Enterobacteriaceae (CRE) among patients with known CRE carriage at their next hospital encounter. Infect Control Hosp Epidemiol: Official J Soc Hosp Epidemiol Am. 2011;32(5):497–503.CrossRef
64.
Zurück zum Zitat Villar HE, Baserni MN, Jugo MB. Faecal carriage of ESBL-producing Enterobacteriaceae and carbapenem-resistant Gram-negative bacilli in community settings. J Infect Dev Ctries. 2013;7(8):630–4.CrossRefPubMed Villar HE, Baserni MN, Jugo MB. Faecal carriage of ESBL-producing Enterobacteriaceae and carbapenem-resistant Gram-negative bacilli in community settings. J Infect Dev Ctries. 2013;7(8):630–4.CrossRefPubMed
65.
Zurück zum Zitat Adler A, Navon-Venezia S, Moran-Gilad J, Marcos E, Schwartz D, Carmeli Y. Laboratory and clinical evaluation of screening agar plates for detection of carbapenem-resistant Enterobacteriaceae from surveillance rectal swabs. J Clin Microbiol. 2011;49(6):2239–42.CrossRefPubMedCentralPubMed Adler A, Navon-Venezia S, Moran-Gilad J, Marcos E, Schwartz D, Carmeli Y. Laboratory and clinical evaluation of screening agar plates for detection of carbapenem-resistant Enterobacteriaceae from surveillance rectal swabs. J Clin Microbiol. 2011;49(6):2239–42.CrossRefPubMedCentralPubMed
66.
Zurück zum Zitat Gazin M, Paasch F, Goossens H, Malhotra-Kumar S, Mosar WP, Teams SWS. Current trends in culture-based and molecular detection of extended-spectrum-beta-lactamase-harboring and carbapenem-resistant Enterobacteriaceae. J Clin Microbiol. 2012;50(4):1140–6.CrossRefPubMedCentralPubMed Gazin M, Paasch F, Goossens H, Malhotra-Kumar S, Mosar WP, Teams SWS. Current trends in culture-based and molecular detection of extended-spectrum-beta-lactamase-harboring and carbapenem-resistant Enterobacteriaceae. J Clin Microbiol. 2012;50(4):1140–6.CrossRefPubMedCentralPubMed
67.
Zurück zum Zitat Lau AF, Wang H, Weingarten RA, Drake SK, Suffredini AF, Garfield MK, et al. A rapid matrix-assisted laser desorption ionization-time of flight mass spectrometry-based method for single-plasmid tracking in an outbreak of carbapenem-resistant Enterobacteriaceae. J Clin Microbiol. 2014;52(8):2804–12.CrossRefPubMedCentralPubMed Lau AF, Wang H, Weingarten RA, Drake SK, Suffredini AF, Garfield MK, et al. A rapid matrix-assisted laser desorption ionization-time of flight mass spectrometry-based method for single-plasmid tracking in an outbreak of carbapenem-resistant Enterobacteriaceae. J Clin Microbiol. 2014;52(8):2804–12.CrossRefPubMedCentralPubMed
68.
Zurück zum Zitat Doyle D, Peirano G, Lascols C, Lloyd T, Church DL, Pitout JD. Laboratory detection of Enterobacteriaceae that produce carbapenemases. J Clin Microbiol. 2012;50(12):3877–80.CrossRefPubMedCentralPubMed Doyle D, Peirano G, Lascols C, Lloyd T, Church DL, Pitout JD. Laboratory detection of Enterobacteriaceae that produce carbapenemases. J Clin Microbiol. 2012;50(12):3877–80.CrossRefPubMedCentralPubMed
69.•
Zurück zum Zitat Poulou A, Voulgari E, Vrioni G, Xidopoulos G, Pliagkos A, Chatzipantazi V, et al. Imported Klebsiella pneumoniae carbapenemase-producing K. pneumoniae clones in a Greek hospital: impact of infection control measures for restraining their dissemination. J Clin Microbiol. 2012;50(8):2618–23. This study described the impact that can be made by a “package” of IPC practices, and re-emphasises the need for a multi-faceted approach.CrossRefPubMedCentralPubMed Poulou A, Voulgari E, Vrioni G, Xidopoulos G, Pliagkos A, Chatzipantazi V, et al. Imported Klebsiella pneumoniae carbapenemase-producing K. pneumoniae clones in a Greek hospital: impact of infection control measures for restraining their dissemination. J Clin Microbiol. 2012;50(8):2618–23. This study described the impact that can be made by a “package” of IPC practices, and re-emphasises the need for a multi-faceted approach.CrossRefPubMedCentralPubMed
70.
Zurück zum Zitat Kochar S ST, Sharma R, et al. Vital Signs: Carbapenem-resistant Enterobacteriaceae. In: Morbidity and mortality weekly report (MMWR). vol. 09. Atlanta: Centers for Disease Control and Prevention; 2013: 165–170. Kochar S ST, Sharma R, et al. Vital Signs: Carbapenem-resistant Enterobacteriaceae. In: Morbidity and mortality weekly report (MMWR). vol. 09. Atlanta: Centers for Disease Control and Prevention; 2013: 165–170.
71.
Zurück zum Zitat Landman D, Babu E, Shah N, Kelly P, Olawole O, Backer M, et al. Transmission of carbapenem-resistant pathogens in New York City hospitals: progress and frustration. J Antimicrob Chemother. 2012;67(6):1427–31.CrossRefPubMed Landman D, Babu E, Shah N, Kelly P, Olawole O, Backer M, et al. Transmission of carbapenem-resistant pathogens in New York City hospitals: progress and frustration. J Antimicrob Chemother. 2012;67(6):1427–31.CrossRefPubMed
72.
Zurück zum Zitat Zimmerman FS, Assous MV, Bdolah-Abram T, Lachish T, Yinnon AM, Wiener-Well Y. Duration of carriage of carbapenem-resistant Enterobacteriaceae following hospital discharge. Am J Infect Control. 2013;41(3):190–4.CrossRefPubMed Zimmerman FS, Assous MV, Bdolah-Abram T, Lachish T, Yinnon AM, Wiener-Well Y. Duration of carriage of carbapenem-resistant Enterobacteriaceae following hospital discharge. Am J Infect Control. 2013;41(3):190–4.CrossRefPubMed
73.
Zurück zum Zitat Feldman N, Adler A, Molshatzki N, Navon-Venezia S, Khabra E, Cohen D, et al. Gastrointestinal colonization by KPC-producing Klebsiella pneumoniae following hospital discharge: duration of carriage and risk factors for persistent carriage. Clin Microbiol Infect: Off Publ Eur Soc Clin Microbiol Infect Dis. 2013;19(4):E190–6.CrossRef Feldman N, Adler A, Molshatzki N, Navon-Venezia S, Khabra E, Cohen D, et al. Gastrointestinal colonization by KPC-producing Klebsiella pneumoniae following hospital discharge: duration of carriage and risk factors for persistent carriage. Clin Microbiol Infect: Off Publ Eur Soc Clin Microbiol Infect Dis. 2013;19(4):E190–6.CrossRef
74.
Zurück zum Zitat Savard P, Perl TM. Combating the spread of carbapenemases in Enterobacteriaceae: a battle that infection prevention should not lose. Clin Microbiol Infect: Off Publ Eur Soc Clin Microbiol Infect Dis. 2014;20(9):854–61.CrossRef Savard P, Perl TM. Combating the spread of carbapenemases in Enterobacteriaceae: a battle that infection prevention should not lose. Clin Microbiol Infect: Off Publ Eur Soc Clin Microbiol Infect Dis. 2014;20(9):854–61.CrossRef
75.
Zurück zum Zitat Drees M, Pineles L, Harris AD, Morgan DJ. Variation in definitions and isolation procedures for multidrug-resistant Gram-negative bacteria: a survey of the Society for Healthcare Epidemiology of America Research Network. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):362–6.CrossRef Drees M, Pineles L, Harris AD, Morgan DJ. Variation in definitions and isolation procedures for multidrug-resistant Gram-negative bacteria: a survey of the Society for Healthcare Epidemiology of America Research Network. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):362–6.CrossRef
76.
Zurück zum Zitat Saidel-Odes L, Polachek H, Peled N, Riesenberg K, Schlaeffer F, Trabelsi Y, et al. A randomized, double-blind, placebo-controlled trial of selective digestive decontamination using oral gentamicin and oral polymyxin E for eradication of carbapenem-resistant Klebsiella pneumoniae carriage. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2012;33(1):14–9.CrossRef Saidel-Odes L, Polachek H, Peled N, Riesenberg K, Schlaeffer F, Trabelsi Y, et al. A randomized, double-blind, placebo-controlled trial of selective digestive decontamination using oral gentamicin and oral polymyxin E for eradication of carbapenem-resistant Klebsiella pneumoniae carriage. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2012;33(1):14–9.CrossRef
77.
Zurück zum Zitat Vandenbroucke-Grauls CM, Vandenbroucke JP. Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit. Lancet. 1991;338(8771):859–62.CrossRefPubMed Vandenbroucke-Grauls CM, Vandenbroucke JP. Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit. Lancet. 1991;338(8771):859–62.CrossRefPubMed
78.
Zurück zum Zitat Liberati A, D’Amico R, Pifferi S, Torri V, Brazzi L, Parmelli E. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev. 2009;4:CD000022.PubMed Liberati A, D’Amico R, Pifferi S, Torri V, Brazzi L, Parmelli E. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev. 2009;4:CD000022.PubMed
79.
Zurück zum Zitat Silvestri L, van Saene HK, de la Cal MA, Zandstra DF, Viviani M, Peric M, et al. Surviving sepsis campaign needed consensus to exclude selective decontamination of the digestive tract. Crit Care Med. 2008;36(9):2716–7.CrossRefPubMed Silvestri L, van Saene HK, de la Cal MA, Zandstra DF, Viviani M, Peric M, et al. Surviving sepsis campaign needed consensus to exclude selective decontamination of the digestive tract. Crit Care Med. 2008;36(9):2716–7.CrossRefPubMed
80.
Zurück zum Zitat Schwaber MJ, Lev B, Israeli A, Solter E, Smollan G, Rubinovitch B, et al. Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention. Clin Infect Dis: Off Publ Infect Dis Soc Am. 2011;52(7):848–55.CrossRef Schwaber MJ, Lev B, Israeli A, Solter E, Smollan G, Rubinovitch B, et al. Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention. Clin Infect Dis: Off Publ Infect Dis Soc Am. 2011;52(7):848–55.CrossRef
81.
Zurück zum Zitat Carmeli Y, Akova M, Cornaglia G, Daikos GL, Garau J, Harbarth S, et al. Controlling the spread of carbapenemase-producing Gram-negatives: therapeutic approach and infection control. Clin Microbiol Infect: Off Publ Eur Soc Clin Microbiol Infect Dis. 2010;16(2):102–11.CrossRef Carmeli Y, Akova M, Cornaglia G, Daikos GL, Garau J, Harbarth S, et al. Controlling the spread of carbapenemase-producing Gram-negatives: therapeutic approach and infection control. Clin Microbiol Infect: Off Publ Eur Soc Clin Microbiol Infect Dis. 2010;16(2):102–11.CrossRef
82.
Zurück zum Zitat Oren I, Sprecher H, Finkelstein R, Hadad S, Neuberger A, Hussein K, et al. Eradication of carbapenem-resistant Enterobacteriaceae gastrointestinal colonization with nonabsorbable oral antibiotic treatment: a prospective controlled trial. Am J Infect Control. 2013;41(12):1167–72.CrossRefPubMed Oren I, Sprecher H, Finkelstein R, Hadad S, Neuberger A, Hussein K, et al. Eradication of carbapenem-resistant Enterobacteriaceae gastrointestinal colonization with nonabsorbable oral antibiotic treatment: a prospective controlled trial. Am J Infect Control. 2013;41(12):1167–72.CrossRefPubMed
83.
Zurück zum Zitat Lubbert C, Faucheux S, Becker-Rux D, Laudi S, Durrbeck A, Busch T, et al. Rapid emergence of secondary resistance to gentamicin and colistin following selective digestive decontamination in patients with KPC-2-producing Klebsiella pneumoniae: a single-centre experience. Int J Antimicrob Agents. 2013;42(6):565–70.CrossRefPubMed Lubbert C, Faucheux S, Becker-Rux D, Laudi S, Durrbeck A, Busch T, et al. Rapid emergence of secondary resistance to gentamicin and colistin following selective digestive decontamination in patients with KPC-2-producing Klebsiella pneumoniae: a single-centre experience. Int J Antimicrob Agents. 2013;42(6):565–70.CrossRefPubMed
84.
Zurück zum Zitat Kontopidou F, Giamarellou H, Katerelos P, Maragos A, Kioumis I, Trikka-Graphakos E, et al. Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options. Clin Microbiol Infect: Off Publ Eur Soc Clin Microbiol Infect Dis. 2014;20(2):O117–23.CrossRef Kontopidou F, Giamarellou H, Katerelos P, Maragos A, Kioumis I, Trikka-Graphakos E, et al. Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options. Clin Microbiol Infect: Off Publ Eur Soc Clin Microbiol Infect Dis. 2014;20(2):O117–23.CrossRef
85.
Zurück zum Zitat Mathers AJ, Poulter M, Dirks D, Carroll J, Sifri CD, Hazen KC. Clinical microbiology costs for methods of active surveillance for Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):350–5.CrossRef Mathers AJ, Poulter M, Dirks D, Carroll J, Sifri CD, Hazen KC. Clinical microbiology costs for methods of active surveillance for Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae. Infect Control Hosp Epidemiol: Off J Soc Hosp Epidemiol Am. 2014;35(4):350–5.CrossRef
86.
Zurück zum Zitat O’Neil J. Review on antimicrobial resistance. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. In: Edited by resistance RoA, 01 edn. London, UK; 2014. O’Neil J. Review on antimicrobial resistance. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. In: Edited by resistance RoA, 01 edn. London, UK; 2014.
Metadaten
Titel
The Pros, Cons, and Unknowns of Search and Destroy for Carbapenem-Resistant Enterobacteriaceae
verfasst von
Prashini Moodley
Andrew Whitelaw
Publikationsdatum
01.06.2015
Verlag
Springer US
Erschienen in
Current Infectious Disease Reports / Ausgabe 6/2015
Print ISSN: 1523-3847
Elektronische ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-015-0483-8

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