Erschienen in:
17.10.2023 | Review article
The role of a novel mineralocorticoid receptor antagonist, finerenone, in chronic kidney disease: mechanisms and clinical advances
verfasst von:
Xinping Chen, Xuan Li, Kexin Zhang, Kexin Lian, Wenqiang Zhang, Yixin Song, Chengxia Kan, Jingwen Zhang, Fang Han, Xiaodong Sun, Zhentao Guo
Erschienen in:
Clinical and Experimental Nephrology
|
Ausgabe 2/2024
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Abstract
Background
Chronic kidney disease (CKD) poses a significant health risk in contemporary society. Current CKD treatments primarily involve renin-angiotensin-aldosterone system inhibitors and mineralocorticoid receptor antagonists, albeit associated with hyperkalemia risks. A novel selective mineralocorticoid receptor antagonist, finerenone, offers a promising, safer alternative for CKD therapy.
Summary
This review comprehensively assesses the role and efficacy of finerenone in CKD treatment by analyzing clinical and animal studies. Emerging evidence consistently supports finerenone's ability to effectively slow the progression of CKD. By targeting the mineralocorticoid receptor, finerenone not only mitigates renal damage but also exhibits a favorable safety profile, minimizing hyperkalemia concerns.
Conclusion
Finerenone emerges as a valuable addition to CKD therapy, demonstrating potential benefits in delaying CKD progression while minimizing side effects. Nevertheless, further clinical trials are necessary to provide a comprehensive understanding of its safety and efficacy.