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Inflammation
Erschienen in: Inflammation 4/2018

14.04.2018 | REVIEW

The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation

verfasst von: Jonathan M. Bekisz, Christopher D. Lopez, Carmen Corciulo, Aranzazu Mediero, Paulo G. Coelho, Lukasz Witek, Roberto L. Flores, Bruce N. Cronstein

Erschienen in: Inflammation | Ausgabe 4/2018

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Abstract

Adenosine receptor activation has been explored as a modulator of the inflammatory process that propagates osteoarthritis. It has been reported that cartilage has enhanced regenerative potential when influenced by adenosine receptor activation. As adenosine’s role in maintaining chondrocyte homeostasis at the cellular and molecular levels is explored, successful in vivo applications of adenosine delivery for cartilage repair continue to be reported. This review summarizes the role adenosine receptor ligation plays in chondrocyte homeostasis and regeneration of articular cartilage damaged in osteoarthritis. It also reports on all the modalities reported for delivery of adenosine through in vivo applications.
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Metadaten
Titel
The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation
verfasst von
Jonathan M. Bekisz
Christopher D. Lopez
Carmen Corciulo
Aranzazu Mediero
Paulo G. Coelho
Lukasz Witek
Roberto L. Flores
Bruce N. Cronstein
Publikationsdatum
14.04.2018
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 4/2018
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-018-0781-z

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