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Reviews in Endocrine and Metabolic Disorders

Erschienen in:

01.06.2014

The role of adiponectin signaling in metabolic syndrome and cancer

verfasst von: Michael P. Scheid, Gary Sweeney

Erschienen in: Reviews in Endocrine and Metabolic Disorders | Ausgabe 2/2014

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Abstract

The increased prevalence of obesity has mandated extensive research focused on mechanisms responsible for associated clinical complications. Emerging from the focus on adipose tissue biology as a vitally important adipokine is adiponectin which is now believed to mediate anti-diabetic, anti-atherosclerotic, anti-inflammatory, cardioprotective and cancer modifying actions. Adiponectin mediates these primarily beneficial effects via direct signaling effects and via enhancing insulin sensitivity via crosstalk with insulin signaling pathways. Reduced adiponectin action is detrimental and occurs in obesity via decreased circulating levels of adiponectin action or development of adiponectin resistance. This review will focus on cellular mechanisms of adiponectin action, their crosstalk with insulin signaling and the resultant role of adiponectin in cardiovascular disease, diabetes and cancer and reviews data from in vitro cell based studies through animal models to clinical observations.

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Titel: The role of adiponectin signaling in metabolic syndrome and cancer
verfasst von: Michael P. Scheid
Gary Sweeney
Publikationsdatum: 01.06.2014
Verlag: Springer US
Erschienen in: Reviews in Endocrine and Metabolic Disorders / Ausgabe 2/2014
Print ISSN: 1389-9155
Elektronische ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-013-9265-5

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