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Current Urology Reports
Erschienen in: Current Urology Reports 1/2013

01.02.2013 | Kidney Diseases (G Ciancio, Section Editor)

The Role of Claudin in Hypercalciuric Nephrolithiasis

verfasst von: Jianghui Hou

Erschienen in: Current Urology Reports | Ausgabe 1/2013

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Abstract

Calcium nephrolithiasis is a common condition. Family-based genetic linkage studies and genome-wide association studies (GWASs) have uncovered a run of important candidate genes involved in renal Ca++ disorders and kidney stone diseases. The susceptible genes include NKCC2, ROMK and ClCkb/Barttin that underlie renal salt excretion; claudin-14, -16 and -19 that underlie renal Ca++ excretion; and CaSR that provides a sensing mechanism for the kidney to regulate salt, water and Ca++ homeostasis. Biological and physiological analyses have revealed the cellular mechanism for transepithelial Ca++ transport in the kidney that depends on the concerted action of these gene products. Although the individual pathogenic weight of the susceptible genes in nephrolithiasis remains unclear, perturbation of their expression or function compromises the different steps within the integrated pathway for Ca++ reabsorption, providing a physiological basis for diagnosing and managing kidney stone diseases.
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Metadaten
Titel
The Role of Claudin in Hypercalciuric Nephrolithiasis
verfasst von
Jianghui Hou
Publikationsdatum
01.02.2013
Verlag
Current Science Inc.
Erschienen in
Current Urology Reports / Ausgabe 1/2013
Print ISSN: 1527-2737
Elektronische ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-012-0289-2

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