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International Journal of Hematology
Erschienen in: International Journal of Hematology 2/2020

01.02.2020 | Progress in Hematology

The role of driver mutations in myeloproliferative neoplasms: insights from mouse models

verfasst von: Kotaro Shide

Erschienen in: International Journal of Hematology | Ausgabe 2/2020

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Abstract

High frequency of JAK2V617F or CALR exon 9 mutations is a main molecular feature of myeloproliferative neoplasms (MPNs). Analysis of mouse models driven by these mutations suggests that they are a direct cause of MPNs and that the expression levels of the mutated genes define the disease phenotype. The function of MPN-initiating cells has also been elucidated by these mouse models. Such mouse models also play an important role in modeling disease to investigate the effects and action mechanisms of therapeutic drugs, such as JAK2 inhibitors and interferon α, against MPNs. The mutation landscape of hematological tumors has already been clarified by next-generation sequencing technology, and the importance of functional analysis of mutant genes in vivo should increase further in the future.
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Metadaten
Titel
The role of driver mutations in myeloproliferative neoplasms: insights from mouse models
verfasst von
Kotaro Shide
Publikationsdatum
01.02.2020
Verlag
Springer Singapore
Erschienen in
International Journal of Hematology / Ausgabe 2/2020
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-019-02803-x

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