Introduction
Methods
Study design and data description
Statistical analysis to identify the risk factor for OSCC
Results
Patients characteristics
Non-matched | Matched | |||
---|---|---|---|---|
Cases n = 544 n (%) | Controls n = 359 n (%) | Cases n = 255 n (%) | Controls n = 255 n (%) | |
Age | ||||
Median | 63 (18–98) | 61 (24–96) | 64 (18–98) | 61 (20–96) |
Gender | ||||
Male | 319 (58.6) | 83 (23.1) | 82 (32.2) | 82 (32.2) |
Female | 225 (41.4) | 276 (76.9) | 173 (67.8) | 173 (67.8) |
Race | ||||
White | 496 (92.7) | 284 (79.1) | 230 (90.2) | 203 (79.6) |
Black | 17 (3.2) | 17 (4.7) | 7 (2.7) | 15 (5.9) |
Asian/Pacific Islander | 12 (2.2) | 14 (3.9) | 9 (3.5) | 11 (4.3) |
Hispanic | 3 (0.6) | 27 (7.5) | 0 (0.0) | 16 (6.3) |
Other | 7 (1.3) | 2 (0.6) | 4 (1.6) | 2 (0.8) |
BMIa | ||||
Median (Range) | 25 (18.8–36.8) | 25.7 (20.1–39.1) | 25.1 (18.8–37.3) | 26.3 (21.1–39.1) |
OSCC Siteb | ||||
Floor of the Mouth (C.04) | 158 (29.0) | 0 (0.0) | 64 (25.1) | 0 (0.0) |
Gingiva (C.03) | 114 (20.9) | 0 (0.0) | 45 (17.6) | 0 (0.0) |
Palate (C.05) | 77 (14.1) | 0 (0.0) | 42 (16.4) | 0 (0.0) |
Mouth, NOS (C.06.9) | 71 (13.2) | 0 (0.0) | 39 (15.3) | 0 (0.0) |
Buccal Mucosa (C.06) | 65 (11.9) | 0 (0.0) | 34 (13.3) | 0 (0.0) |
Retromolar area (C.06.2) | 45 (8.3) | 0 (0.0) | 16 (6.3) | 0 (0.0) |
Tongue (C.02.9) | 11 (2.1) | 0 (0.0) | 14 (5.5) | 0 (0.0) |
Labial mucosa (C.00.5) | 3 (0.5) | 0 (0.0) | 1 (0.4) | 0 (0.0) |
Tobacco History | ||||
Never | 138 (25.4) | 230 (64.1) | 131 (51.4) | 131 (51.4) |
Former | 293 (53.8) | 114 (31.8) | 109 (42.7) | 109 (42.7) |
Current | 113 (20.8) | 15 (4.1) | 15 (5.9) | 15 (5.9) |
Median Pack/years (Range) | 40 (1–160) | 10 (1–60) | 30 (1–160) | 10 (1–60) |
Alcohol consumption | ||||
Never drinker | 147 (27.0) | 164 (45.7) | 126 (49.4) | 126 (49.4) |
Former | 99 (18.2) | 12 (3.3) | 9 (3.5) | 9 (3.5) |
Current | 298 (54.8) | 183 (51.0) | 120 (47.0) | 120 (47.0) |
Median Drinks/week (Range) | 12 (1–105) | 3 (1–28) | 7 (1–45) | 5 (1–28) |
Family history of cancer and head and neck cancer
Cases n = 255 | Controls n = 255 | p-value | OR | 95% CI | |
---|---|---|---|---|---|
Family history of cancera | |||||
Overall family | |||||
Negative | 127 (49.8) | 130 (51.0) | 0.48 | 0.95 | 0.82–1.1 |
Positive | 128 (50.2) | 125 (49.0) | |||
1 | 72 (28,2) | 67 (26.3) | |||
2 | 31 (12.2) | 32 (12.5) | |||
3 | 22 (8.6) | 14 (5.5) | |||
> 3 | 3 (1.2) | 12 (4.9) | |||
Parents | |||||
Negative | 182 (71.7) | 161 (63.4) | < 0.05 | 0.73 | 0.55–0.98 |
Positive | 72 (28.3) | 90 (36.6) | |||
One parent | 58 (22.8) | 72 (28.3) | |||
Both parents | 14 (5.5) | 18 (8.3) | |||
Siblings | |||||
Negative | 203 (79.9) | 221 (87.0) | < 0.01 | 1.59 | 1.17–2.89 |
Positive | 51 (20.1) | 33 (13.0) | |||
1 | 35 (13,8) | 29 (11.4) | |||
2 | 15 (5.9) | 4 (1.6) | |||
3 | 1 (0.4) | 0 | |||
Children | |||||
Negative | 248 (97.2) | 250 (98.4) | 0.52 | 1.50 | 0.42–5.31 |
Positive | 7 (2.8) | 5 (1.6) | |||
Second degree | |||||
Negative | 228 (89.8) | 227 (89.4) | 0.30 | 0.87 | 0.67–1.13 |
Positive | 26 (10.2) | 27 (10.6) | |||
1 | 16 (6.3) | 15 (5.9) | |||
2 | 8 (3.1) | 5 (2.0) | |||
> 2 | 2 (0.8) | 7 (2.8) | |||
Grandparents | |||||
Negative | 244 (96.1) | 237 (93.3) | 0.06 | 0.53 | 0.27–1.03 |
Positive | 10 (3.9) | 17 (6.7) | |||
1 | 10 (3.9) | 11 (4.3) | |||
2 | 0 | 4 (1.6) | |||
3 | 0 | 2 (0.8) | |||
Family history of head and neck cancera | |||||
Negative | 240 (94.3) | 244 (96.6) | 0.75 | 1.11 | 0.59–2.07 |
Positive | 15 (5.7) | 11 (3.4) | |||
1 | 14 (5.3) | 10 (3.0) | |||
> 1 | 1 (0.4) | 1 (0.4) |
Other primary and secondary risk factors for OSCC
Primary factors | Cases n = 255 n (%) | Controls n = 255 n (%) | p-value | Odds ratio (95% CI) |
---|---|---|---|---|
Prior personal cancer history | 24 (9.4) | 31 (12.1) | 0.25 | |
Solid cancer (excluding HNC) | 16 (6.3) | 29 (11.4) | 0.05 | 0.53 (0.28–1.0) |
Hematologic cancer | 1 (0.4) | 2 (1.2) | 0.21 | 0.5 (0.04–5.5) |
Prior HNC | 7 (3.5) | 0 (0.0) | 0.99 | N/A |
Secondary factors | ||||
History of dysplasia/leukoplakia | 47 (18.4) | 3 (1.2) | < 0.01 | 15.6 (4.87–50.3) |
History of head and neck RT | 7 (2.7) | 0 (0.0) | 0.99 | N/A |