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01.12.2018 | Review | Ausgabe 1/2018 Open Access

Journal of Translational Medicine 1/2018

The role of HIV Tat protein in HIV-related cardiovascular diseases

Zeitschrift:
Journal of Translational Medicine > Ausgabe 1/2018
Autoren:
Yanan Jiang, Lu Chai, Moyondafoluwa Blessing Fasae, Yunlong Bai

Abstract

The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regulatory protein encoded by tat gene of HIV-1, which not only promotes the transcription of HIV, but it is also involved in the pathogenesis of HIV-related complications. This review is aimed at summarizing the current understanding of Tat in HIV-related cardiovascular diseases.
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