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Current Psychiatry Reports
Erschienen in: Current Psychiatry Reports 3/2010

01.06.2010

The Role of the Entorhinal Cortex in Paraphrenia

verfasst von: Manuel F. Casanova

Erschienen in: Current Psychiatry Reports | Ausgabe 3/2010

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Abstract

Evidence derived from postmortem brain studies has implicated the uncal cortex in paraphrenia. In the present review, we expand on the anatomic and physiologic nuances endogenous to this region that make entorhinal cortex pathology an important clinicopathological correlate to paraphrenia. First, we summarize the anatomic landmarks and histologic features that will allow the reader to define the entorhinal region in future research studies. As cortical regions usually project to neighboring cortices, inferences will be drawn as to the function of the entorhinal region based on the surrounding cortical regions. The results will help explain why patients with paraphrenia may exhibit amnestic deficits that stand in contrast to a well-preserved thought process and personality. We also review the results of surgical ablation studies in animals. These studies suggest that some risk factors currently associated with paraphrenia (eg, social isolation) may in reality be an early manifestation of entorhinal pathology. Finally, the author provides a parallelism between the hallucinations observed in some paraphrenic patients and the results of electrical stimulation of the uncal cortex. The results will help explain why hallucinations in paraphrenia are usually limited to the patient’s surroundings.
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Metadaten
Titel
The Role of the Entorhinal Cortex in Paraphrenia
verfasst von
Manuel F. Casanova
Publikationsdatum
01.06.2010
Verlag
Current Science Inc.
Erschienen in
Current Psychiatry Reports / Ausgabe 3/2010
Print ISSN: 1523-3812
Elektronische ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-010-0109-7

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