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Medical Microbiology and Immunology

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01.06.2008 | Review

The salivary glands as a privileged site of cytomegalovirus immune evasion and persistence

verfasst von: Ann E. Campbell, Victoria J. Cavanaugh, Jacquelyn S. Slater

Erschienen in: Medical Microbiology and Immunology | Ausgabe 2/2008

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Abstract

The salivary glands (SG) provide a haven for persistent cytomegalovirus replication, and in this regard are a privileged site of virus immune evasion. The murine cytomegalovirus (MCMV) model has provided insight into the immunological environment of the SG and the unqiue virus–host relationship of this organ. In response to MCMV infection, a robust T cell-mediated immune response is elicited, comprised predominantly of CD8+ T cells that phenotypically and functionally appear activated. However, they fail to clear virus by an unknown evasion mechanism that is independent of inhibitory NKG2A- or Programmed Death 1-mediated signaling. Virus is eventually eliminated from the SG by effector CD4+ T cells expressing antiviral cytokines. However, this mechanism is severely dampened by high levels of the immunosuppressive cytokine IL-10, selectively expressed by SG CD4+ T cells.

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Titel: The salivary glands as a privileged site of cytomegalovirus immune evasion and persistence
verfasst von: Ann E. Campbell
Victoria J. Cavanaugh
Jacquelyn S. Slater
Publikationsdatum: 01.06.2008
Verlag: Springer Berlin Heidelberg
Erschienen in: Medical Microbiology and Immunology / Ausgabe 2/2008
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-008-0077-2

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