Background
Methods
Patients
Treatment and pain evaluation
DNA extraction and 5-HTTLPR genotyping
Statistical analysis
Results
TN (n = 244)
|
Control (n = 280)
|
P
| |
---|---|---|---|
Characteristics
| |||
Mean age (yrs)
|
55.06 (38.7-67.8)
|
54.93 (38.5-69.1)
|
0.876
|
Sex
| |||
Male
|
100
|
112
|
0.432
|
Female
|
144
|
168
| |
Smoking status
| |||
Never
|
70
|
115
|
<0.001
|
Ever
|
94
|
87
| |
Current
|
80
|
78
| |
Symptom Duration (months)
|
40.3 (2.6-56.7)
| ||
Pain location
| |||
V1
|
10
| ||
V2
|
127
| ||
V3
|
107
| ||
Pain severity
| |||
<III
|
81
| ||
>TTT
|
163
|
Genotype
|
TN
|
Control
|
Adjusted OR
|
95% CI
|
Adjusted P
| ||||
---|---|---|---|---|---|---|---|---|---|
5-HTTLPR
|
Long-long
|
58
|
23.77%
|
103
|
36.79%
|
1.000
| |||
Long-short
|
99
|
40.57%
|
129
|
46.07%
|
1.363
|
0.900
|
2.064
|
0.143
| |
Short-short
|
87
|
35.66%
|
48
|
17.14%
|
3.219
|
1.997
|
5.187
|
0.000
| |
Long
|
215
|
44.06%
|
335
|
59.82%
|
1.000
| ||||
short
|
273
|
55.94%
|
225
|
40.18%
|
1.891
|
1.478
|
2.418
|
0.045
| |
rs25531 |
AA
| 68 | 27.87% | 75 | 26.79% | 1.000 | |||
AG
| 114 | 46.72% | 135 | 48.21% | 0.931 | 0.617 | 1.406 | 0.735 | |
GG
| 62 | 25.41% | 70 | 25.00% | 0.977 | 0.608 | 1.569 | 0.923 | |
A
| 250 | 51.23% | 285 | 50.89% | 1.000 | ||||
G
| 238 | 48.77% | 275 | 49.11% | 0.987 | 0.774 | 1.258 | 0.913 |
Genotype
|
TN with BNI grade (IV-V)
|
TN with BNI grade scores (I-III)
|
Adjusted OR
|
95% CI
|
Adjusted P
| ||||
---|---|---|---|---|---|---|---|---|---|
5-HTTLPR
|
Long-long
|
40
|
24.54%
|
34
|
41.98%
|
1.000
| |||
Long-short
|
75
|
46.01%
|
39
|
48.15%
|
1.635
|
0.898
|
2.975
|
0.107
| |
Short-short
|
48
|
29.45%
|
8
|
9.88%
|
5.100
|
2.122
|
12.260
|
0.000
| |
Long
|
155
|
47.55%
|
107
|
66.05%
|
1.000
| ||||
short
|
171
|
52.45%
|
55
|
33.95%
|
2.146
|
1.451
|
3.174
|
0.034
| |
rs25531 |
AA
| 35 | 21.47% | 17 | 20.99% | 1.000 | |||
AG
| 96 | 58.90% | 41 | 50.62% | 1.137 | 0.573 | 2.256 | 0.713 | |
GG
| 32 | 19.63% | 23 | 28.40% | 0.676 | 0.307 | 1.488 | 0.329 | |
A
| 166 | 50.92% | 75 | 46.30% | 1.000 | ||||
G
| 160 | 49.08% | 87 | 53.70% | 0.831 | 0.570 | 1.212 | 0.336 |
Dose |
Treatment without improvement
|
Treatment with improvement
| P |
---|---|---|---|
400 mg/day |
34
| 55 | 0.620 |
800 mg/day |
33
| 71 | |
>800 mg/day |
9
| 15 | |
Discontinuation due to side effect | 11 | 6 | 0.568 |
Discontinuation due to interventional or surgical treatment | 6 | 4 | 0.448 |
Genotype
|
Treatment without improvement
|
Treatment with improvement
|
Adjusted OR
|
95% CI
|
Adjusted P
| ||||
---|---|---|---|---|---|---|---|---|---|
5-HTTLPR
|
Long-long
| 15 | 19.74% | 46 | 32.62% | 1.000 | |||
Long-short
| 39 | 51.32% | 72 | 51.06% | 1.661 | 0.824 | 3.349 | 0.154 | |
Short-short
| 22 | 28.95% | 23 | 16.31% | 2.933 | 1.285 | 6.696 | 0.009 | |
Long
| 69 | 45.39% | 164 | 58.16% | 1.000 | ||||
short
| 83 | 54.61% | 118 | 41.84% | 1.672 | 1.124 | 2.488 | 0.011 | |
rs25531 |
AA
| 13 | 17.11% | 31 | 21.99% | 1.000 | |||
AG
| 45 | 59.21% | 76 | 53.90% | 1.412 | 0.670 | 2.975 | 0.363 | |
GG
| 18 | 23.68% | 34 | 24.11% | 1.262 | 0.532 | 2.994 | 0.597 | |
A
| 71 | 46.71% | 138 | 48.94% | 1.000 | ||||
G
| 81 | 53.29% | 144 | 51.06% | 1.093 | 0.737 | 1.623 | 0.851 |