The online version of this article (doi:10.1186/1129-2377-15-70) contains supplementary material, which is available to authorized users.
All authors declare there are non-financial competing interests (political, personal, religious, ideological, academic, intellectual, commercial or any other) in relation to this manuscript.
MD, WXQ, LSY, XMW, ZX, ZF, DW, SXB, WM, MYF, CYN and YSY carried out the studies. And WXQ drafted the manuscript. M.D. WXQ participated in the design of the study and performed the statistical analysis. Professor YSY, the PI of this study, conceived of the study and participated in its design and helped to draft the manuscript. All authors read and approved the final manuscript.
To examine the association between headaches and epilepsy.
Consecutive adult epileptic patients who went to the outpatient clinic of the Epilepsy Center of PLA General Hospital between February 01, 2012, and May 10, 2013, were recruited into this study. A total of 1109 patients with epilepsy completed a questionnaire regarding headaches.
Overall, 60.1% of the patients (male: 57.2%; female: 63.8%) reported headaches within the last year. The age-weighted prevalence of interictal migraine was 11.7% (male 8.9%, female 15.3%), which is higher than that reported in a large population-based study (8.5%, male 5.4%, female 11.6%) using the same screening questions. The prevalence of postictal headaches was 34.1% (males 32.7%, females 35.2%), and the presence of preictal headaches was 4.5% (males 4.3%, females 5.2%). The prevalence of headache yesterday in the general population was 4.8% (male 3.0%, female 6.6%). Thus, the prevalence of headaches, including migraine, is higher in epileptic patients in China.
The high prevalence of postictal headaches confirms the frequent triggering of a headache by a seizure. A much lower frequency of preictal headaches, a condition in which the real triggering effect of the headache on the seizure might be difficult to prove.
Lj S, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, Steiner T, Zwart JA: The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 2007, 27: 193–210. 10.1111/j.1468-2982.2007.01288.x CrossRef
Vanmolkot KR, Kors EE, Hottenga JJ, Terwindt GM, Haan J, Hoefnagels WA, Black DF, Sandkuijl LA, Frants RR, Ferrari MD, van den Maagdenberg AM: Novel mutations in the Na+, K + −ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions. Ann Neurol 2003, 54: 360–366. 10.1002/ana.10674 CrossRefPubMed
Ottman R, Lipton RB, Ettinger AB, Cramer JA, Reed ML, Morrison A, Wan GJ: Comorbidities of epilepsy: results from the Epilepsy Comorbidities and Health (EPIC) survey. Epilepsy 2011, 52: 308–315.
Belcastro V, Striano P, Kasteleijn-Nolst Trenité DG, Villa MP, Parisi P: Migralepsy, hemicrania epileptica, post-ictal headache and "ictal epileptic headache": a proposal for terminology and classification revision. J Headache Pain 2011, 12: 289–294. 10.1007/s10194-011-0318-4 PubMedCentralCrossRefPubMed
Headache Classification Subcommittee of the International Headache Society: The international classification of headache disorders, 2nd edition. Cephalalgia 2004, 24: 9–160. CrossRef
Verrotti A, Coppola G, Di Fonzo A, Tozzi E, Spalice A, Aloisi P, Bruschi R, Iannetti P, Villa MP, Parisi P: Should "migralepsy" be considered an obsolete concept? A multicenter retrospective clinical/EEG study and review of the literature. Epilepsy Behav 2011, 21: 52–9. 10.1016/j.yebeh.2011.03.004 CrossRefPubMed
Verrotti A, Coppola G, Spalice A, Di Fonzo A, Bruschi R, Tozzi E, Iannetti P, Villa MP, Parisi P: Peri-ictal and inter-ictal headache in children and adolescents with idiopathic epilepsy: a multicenter cross-sectional study. Childs Nerv Syst 2011, 27: 1419–23. 10.1007/s00381-011-1428-7 CrossRefPubMed
HELP (Headache in Epileptic Patients) Study Group: Multi-center study on migraine and seizure-related headache in patients with epilepsy. Yonsei Med J 2010, 51: 219–224. CrossRef
- High prevalence of headaches in patients with epilepsy
- Springer Milan
Neu im Fachgebiet AINS
Meistgelesene Bücher aus dem Fachgebiet AINS
Mail Icon II