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Current Psychiatry Reports
Erschienen in: Current Psychiatry Reports 10/2014

01.10.2014 | Bipolar Disorders (W Coryell, Section Editor)

The Significance of Mixed States in Depression and Mania

verfasst von: Giulio Perugi, Giuseppe Quaranta, Liliana Dell’Osso

Erschienen in: Current Psychiatry Reports | Ausgabe 10/2014

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Abstract

The DSM-5 definition of mixed features “specifier” of manic, hypomanic and major depressive episodes captures sub-syndromal non-overlapping symptoms of the opposite pole, experienced in bipolar (I, II, and not otherwise specified) and major depressive disorders. This combinatory model seems to be more appropriate for less severe forms of mixed state, in which mood symptoms are prominent and clearly identifiable. Sub-syndromal depressive symptoms have been frequently reported to co-occur during mania. Similarly, manic or hypomanic symptoms during depression resulted common, dimensionally distributed, and recurrent. The presence of mixed features has been associated with a worse clinical course and high rates of comorbidities including anxiety, personality, alcohol and substance use disorders and head trauma or other neurological problems. Finally, mixed states represent a major therapeutic challenge, especially when you consider that these forms tend to have a less favorable response to drug treatments and require a more complex approach than non-mixed forms.
Literatur
1.
Kraepelin, E., Manic-Depressive Illness and Paranoia, ed. B.R. Robertson GM. 1921, Edinburgh: E & S Livingstone.
2.
Kotin J, Goodwin FK. Depression during mania: clinical observations and theoretical implications. Am J Psychiatry. 1972;129(6):679–86.PubMedCrossRef
3.
Himmelhoch JM et al. Incidence and signficiance of mixed affective states in a bipolar population. Arch Gen Psychiatry. 1976;33(9):1062–6.PubMedCrossRef
4.
Secunda SK et al. Diagnosis and treatment of mixed mania. Am J Psychiatry. 1987;144(1):96–8.PubMedCrossRef
5.
McElroy SL et al. Clinical and research implications of the diagnosis of dysphoric or mixed mania or hypomania. Am J Psychiatry. 1992;149(12):1633–44.PubMedCrossRef
6.
McElroy SL et al. Differences and similarities in mixed and pure mania. Compr Psychiatry. 1995;36(3):187–94.PubMedCrossRef
7.
Swann AC et al. Depression during mania. Treatment response to lithium or divalproex. Arch Gen Psychiatry. 1997;54(1):37–42.PubMedCrossRef
8.
9.
Dell'Osso L et al. The manic-depressive mixed state: familial, temperamental and psychopathologic characteristics in 108 female inpatients. Eur Arch Psychiatry Clin Neurosci. 1991;240(4–5):234–9.PubMedCrossRef
10.
Perugi G et al. Clinical subtypes of bipolar mixed states: validating a broader European definition in 143 cases. J Affect Disord. 1997;43(3):169–80.PubMedCrossRef
11.
Perugi G et al. Clinical characterization of depressive mixed state in bipolar-I patients: Pisa-San Diego collaboration. J Affect Disord. 2001;67(1–3):105–14.PubMedCrossRef
12.
Koukopoulos A. Agitated depression as a mixed state and the problem of melancholia. Psychiatr Clin North Am. 1999;22(3):547–64.PubMedCrossRef
13.
Koukopoulos A et al. Melancholia agitata and mixed depression. Acta Psychiatr Scand Suppl. 2007;433:50–7.PubMedCrossRef
14.
Benazzi F, Akiskal HS. Delineating bipolar II mixed states in the Ravenna-San Diego collaborative study: the relative prevalence and diagnostic significance of hypomanic features during major depressive episodes. J Affect Disord. 2001;67(1–3):115–22.PubMedCrossRef
15.
Akiskal HS et al. Gender, temperament, and the clinical picture in dysphoric mixed mania: findings from a French national study (EPIMAN). J Affect Disord. 1998;50(2–3):175–86.PubMedCrossRef
16.
Bourgeois M, Verdoux H, Mainard CH. Dysphoric mania and mixed states. Encephale. 1995;21(Spec No 6):21–32.PubMed
17.
Swann AC et al. Lithium treatment of mania: clinical characteristics, specificity of symptom change, and outcome. Psychiatry Res. 1986;18(2):127–41.PubMedCrossRef
18.
Cassidy F, Pieper CF, Carroll BJ. Subtypes of mania determined by grade of membership analysis. Neuropsychopharmacology. 2001;25(3):373–83.PubMedCrossRef
19.
Akiskal HS, Benazzi F. Validating Kraepelin’s two types of depressive mixed states: “depression with flight of ideas” and “excited depression”. World J Biol Psychiatry. 2004;5(2):107–13.PubMedCrossRef
20.
APA, A.P.A., Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). 4 ed, Text Revision ed ed. 2000, Washington, DC.
21.
Benazzi F. Depressive mixed state: testing different definitions. Psychiatry Clin Neurosci. 2001;55(6):647–52.PubMedCrossRef
22.
Kim KR et al. Reevaluation of patients with bipolar disorder on manic episode: improving the diagnosing of mixed episode. J Nerv Ment Dis. 2013;201(8):686–90.PubMedCrossRef
23.
McIntyre RS et al. DSM-5 mixed specifier for manic episodes: evaluating the effect of depressive features on severity and treatment outcome using asenapine clinical trial data. J Affect Disord. 2013;150(2):378–83.PubMedCrossRef
24.••
Swann AC et al. Bipolar mixed states: an international society for bipolar disorders task force report of symptom structure, course of illness, and diagnosis. Am J Psychiatry. 2013;170(1):31–42. The article is a very comprehensive and updated review of the current litherature on the clinical characteristics of mixed states.PubMedCrossRef
25.
Bottlender R et al. Mixed depressive features predict maniform switch during treatment of depression in bipolar I disorder. J Affect Disord. 2004;78(2):149–52.PubMedCrossRef
26.
Pae CU et al. Mixed depression: a study of its phenomenology and relation to treatment response. J Affect Disord. 2012;136(3):1059–61.PubMedCrossRef
27.
Goldberg JF et al. Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD. Am J Psychiatry. 2009;166(2):173–81.PubMedCrossRef
28.
Akiskal HS, Benazzi F. The DSM-IV and ICD-10 categories of recurrent [major] depressive and bipolar II disorders: evidence that they lie on a dimensional spectrum. J Affect Disord. 2006;92(1):45–54.PubMedCrossRef
29.
Sato T et al. Irritable psychomotor elation in depressed inpatients: a factor validation of mixed depression. J Affect Disord. 2005;84(2–3):187–96.PubMedCrossRef
30.
Swann AC et al. Structure of mania: depressive, irritable, and psychotic clusters with different retrospectively-assessed course patterns of illness in randomized clinical trial participants. J Affect Disord. 2001;67(1–3):123–32.PubMedCrossRef
31.
Benazzi F, Koukopoulos A, Akiskal HS. Toward a validation of a new definition of agitated depression as a bipolar mixed state (mixed depression). Eur Psychiatry. 2004;19(2):85–90.PubMedCrossRef
32.
Bertschy G et al. Phenomenology of mixed states: a principal component analysis study. Bipolar Disord. 2007;9(8):907–12.PubMedCrossRef
33.
Swann AC et al. Continuum of depressive and manic mixed states in patients with bipolar disorder: quantitative measurement and clinical features. World Psychiatry. 2009;8(3):166–72.PubMedPubMedCentral
34.
35.
Pacchiarotti I et al. Mania and depression. Mixed, not stirred. J Affect Disord. 2011;133(1–2):105–13.PubMedCrossRef
36.
Perugi G et al. Clinical subtypes of severe bipolar mixed states. J Affect Disord. 2013;151(3):1076–82.PubMedCrossRef
37.
Dilsaver SC et al. Depressive mania associated with nonresponse to antimanic agents. Am J Psychiatry. 1993;150(10):1548–51.PubMedCrossRef
38.
Coryell W et al. Bipolar I affective disorder: predictors of outcome after 15 years. J Affect Disord. 1998;50(2–3):109–16.PubMedCrossRef
39.
Akiskal HS et al. Validating the bipolar spectrum in the French National EPIDEP Study: overview of the phenomenology and relative prevalence of its clinical prototypes. J Affect Disord. 2006;96(3):197–205.PubMedCrossRef
40.
Valtonen HM et al. Differences in incidence of suicide attempts during phases of bipolar I and II disorders. Bipolar Disord. 2008;10(5):588–96.PubMedCrossRef
41.
Akiskal HS, Benazzi F. Does the FDA proposed list of possible correlates of suicidality associated with antidepressants apply to an adult private practice population? J Affect Disord. 2006;94(1–3):105–10.PubMedCrossRef
42.
Balazs J et al. The close link between suicide attempts and mixed (bipolar) depression: implications for suicide prevention. J Affect Disord. 2006;91(2–3):133–8.PubMedCrossRef
43.
Abreu LN et al. Suicidal ideation and suicide attempts in bipolar disorder type I: an update for the clinician. Rev Bras Psiquiatr. 2009;31(3):271–80.PubMedCrossRef
44.
Shim IH et al. A reevaluation of the possibility and characteristics in bipolar mania with mixed features: a retrospective chart review. Psychiatry Res. 2014;215(2):335–40.PubMedCrossRef
45.
Gonzalez-Pinto A et al. Epidemiology, diagnosis and management of mixed mania. CNS Drugs. 2007;21(8):611–26.PubMedCrossRef
46.
Sajatovic M et al. Depression symptom ratings in geriatric patients with bipolar mania. Int J Geriatr Psychiatry. 2011;26(11):1201–8.PubMedPubMedCentral
47.
McElroy SL. Understanding the complexity of bipolar mixed episodes. J Clin Psychiatry. 2008;69(2):e06.PubMedCrossRef
48.
Akiskal HS. The distinctive mixed states of bipolar I, II, and III. Clin Neuropharmacol. 1992;15(Suppl 1 Pt A):632A–3.PubMedCrossRef
49.
Cassidy F et al. Signs and symptoms of mania in pure and mixed episodes. J Affect Disord. 1998;50(2–3):187–201.PubMedCrossRef
50.
Swann AC et al. Specificity of mixed affective states: clinical comparison of dysphoric mania and agitated depression. J Affect Disord. 1993;28(2):81–9.PubMedCrossRef
51.
Goldberg JF et al. Qualitative differences in manic symptoms during mixed versus pure mania. Compr Psychiatry. 2000;41(4):237–41.PubMedCrossRef
52.
Suppes T et al. Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon. Arch Gen Psychiatry. 2005;62(10):1089–96.PubMedCrossRef
53.
Akiskal HS, Benazzi F. Family history validation of the bipolar nature of depressive mixed states. J Affect Disord. 2003;73(1–2):113–22.PubMedCrossRef
54.
Zimmermann P et al. Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity. Arch Gen Psychiatry. 2009;66(12):1341–52.PubMedCrossRef
55.
Akiskal HS et al. Agitated “unipolar”depression re-conceptualized as a depressive mixed state: implications for the antidepressant-suicide controversy. J Affect Disord. 2005;85(3):245–58.PubMedCrossRef
56.
Fiedorowicz JG et al. Subthreshold hypomanic symptoms in progression from unipolar major depression to bipolar disorder. Am J Psychiatry. 2011;168(1):40–8.PubMedPubMedCentralCrossRef
57.•
Perugi G et al. Phenomenological subtypes of severe bipolar mixed states: a factor analytic study. Compr Psychiatry. 2014;55(4):799–806. The study is focused on the symptomatological presentation of severe mixed states. Sixty percent of the patients did not showed dominant manic or depressive features and cannot be easily described according to a combinatory model.PubMedCrossRef
58.
Azorin JM, Belzeaux R, Fakra E. Mixed states between schizophrenia and bipolar disorders. Encephale. 2013;39(3):S127–8.PubMedCrossRef
59.
Akiskal HS, Mallya G. Criteria for the “soft” bipolar spectrum: treatment implications. Psychopharmacol Bull. 1987;23(1):68–73.PubMed
60.
Angst, J., et al., Evidence-based definitions of bipolar-I and bipolar-II disorders among 5,635 patients with major depressive episodes in the Bridge Study: validity and comorbidity. Eur Arch Psychiatry Clin Neurosci, 2013.
61.••
Koukopoulos A, Sani G. DSM-5 criteria for depression with mixed features: a farewell to mixed depression. Acta Psychiatr Scand. 2013. doi:10.​1111/​acps.​12140. The article review the available empirical evidence on the clinical presentation of mixed depression, suggesting that the non-evidence based definition of the DSM-5 “specifier” can be misleading and very restrictive.PubMed
62.
Calabrese JR et al. A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression. Am J Psychiatry. 2005;162(7):1351–60.PubMedCrossRef
63.
Jeong JH et al. Efficacy of quetiapine in patients with bipolar I and II depression: a multicenter, prospective, open-label, observational study. Neuropsychiatr Dis Treat. 2013;9:197–204.PubMedPubMedCentralCrossRef
64.
Azorin JM, Sapin C, Weiller E. Effect of asenapine on manic and depressive symptoms in bipolar I patients with mixed episodes: results from post hoc analyses. J Affect Disord. 2013;145(1):62–9.PubMedCrossRef
65.
Michalak EE, Guiraud-Diawara A, Sapin C. Asenapine treatment and health-related quality of life in patients experiencing bipolar I disorder with mixed episodes: post-hoc analyses of pivotal trials. Curr Med Res Opin. 2014;30(4):711–8.PubMedCrossRef
66.
Malhi GS et al. Mixed state discrimination: a DSM problem that wont go away? J Affect Disord. 2014;158:8–10.PubMedCrossRef
67.
Cassidy F, Ahearn E, Carroll BJ. A prospective study of inter-episode consistency of manic and mixed subtypes of bipolar disorder. J Affect Disord. 2001;67(1–3):181–5.PubMedCrossRef
68.
Sato T et al. Evaluating the inter-episode stability of depressive mixed states. J Affect Disord. 2004;81(2):103–13.PubMedCrossRef
69.
Moorhead S, Scott J. Clinical characteristics of familial and non-familial bipolar disorder. Bipolar Disord. 2000;2(2):136–9.PubMedCrossRef
70.
Sato T et al. Frequency of manic symptoms during a depressive episode and unipolar ‘depressive mixed state’ as bipolar spectrum. Acta Psychiatr Scand. 2003;107(4):268–74.PubMedCrossRef
71.
Angst J et al. Major depressive disorder with subthreshold bipolarity in the National Comorbidity Survey Replication. Am J Psychiatry. 2010;167(10):1194–201.PubMedPubMedCentralCrossRef
72.
Maj M et al. Agitated “unipolar” major depression: prevalence, phenomenology, and outcome. J Clin Psychiatry. 2006;67(5):712–9.PubMedCrossRef
73.
Judd LL et al. Prevalence and clinical significance of subsyndromal manic symptoms, including irritability and psychomotor agitation, during bipolar major depressive episodes. J Affect Disord. 2012;138(3):440–8.PubMedPubMedCentralCrossRef
74.
Koukopoulos A et al. Mixed depressive states: nosologic and therapeutic issues. Int Rev Psychiatry. 2005;17(1):21–37.PubMedCrossRef
75.
Perugi G et al. The role of cyclothymia in atypical depression: toward a data-based reconceptualization of the borderline-bipolar II connection. J Affect Disord. 2003;73(1–2):87–98.PubMedCrossRef
76.
Benazzi F. Challenging the unipolar-bipolar division: does mixed depression bridge the gap? Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(1):97–103.PubMedCrossRef
77.
Hantouche EG et al. Clinical and psychometric characterization of depression in mixed mania: a report from the French National Cohort of 1090 manic patients. J Affect Disord. 2006;96(3):225–32.PubMedCrossRef
78.
Goldberg JF, T.C., Fordis J, Wisniewski S, Thase ME, Sachs GS, Antidepressant use during mixed states: naturalistic outcome data from the STEP-1000. Neuropsychopharmacology, 2004. 29.
79.
Bauer MS et al. ‘Bipolarity’ in bipolar disorder: distribution of manic and depressive symptoms in a treated population. Br J Psychiatry. 2005;187:87–8.PubMedCrossRef
80.
Angst J et al. Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. J Affect Disord. 2003;73(1–2):133–46.PubMedCrossRef
81.
Duffy A et al. A prospective study of the offspring of bipolar parents responsive and nonresponsive to lithium treatment. J Clin Psychiatry. 2002;63(12):1171–8.PubMedCrossRef
82.
Serretti A, Olgiati P. Profiles of “manic” symptoms in bipolar I, bipolar II and major depressive disorders. J Affect Disord. 2005;84(2–3):159–66.PubMedCrossRef
83.
Biondi M et al. Dimensional psychopathology of depression: detection of an ‘activation’ dimension in unipolar depressed outpatients. J Affect Disord. 2005;84(2–3):133–9.PubMedCrossRef
84.
Cassano GB et al. Conceptual underpinnings and empirical support for the mood spectrum. Psychiatr Clin North Am. 2002;25(4):699–712. v.PubMedCrossRef
85.
Perugi, G., Angst J., Azorin, J., Bowden C.L., Mosolov, S., Reis, J., Vieta, E., Young, A.H., for the BRIDGE-II-Mix Study Group, Mixed Features in Patients with a Major Depressive Episode: the BRIDGE-II- MIX Study. J Clin Psych 2014.
86.
Benazzi F. Bipolar disorder–focus on bipolar II disorder and mixed depression. Lancet. 2007;369(9565):935–45.PubMedCrossRef
87.
Hoertel N et al. Subthreshold bipolar disorder in a U.S. national representative sample: prevalence, correlates and perspectives for psychiatric nosography. J Affect Disord. 2013;146(3):338–47.PubMedCrossRef
88.
Benazzi F. Is there a continuity between bipolar and depressive disorders? Psychother Psychosom. 2007;76(2):70–6.PubMedCrossRef
89.
Benazzi F. A continuity between bipolar II depression and major depressive disorder? Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(6):1043–50.PubMedCrossRef
90.
Potash JB et al. Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships. Am J Psychiatry. 2000;157(12):2048–50.PubMedCrossRef
91.
Garno JL et al. Bipolar disorder with comorbid cluster B personality disorder features: impact on suicidality. J Clin Psychiatry. 2005;66(3):339–45.PubMedCrossRef
92.
Goldstein BI, Levitt AJ. The specific burden of comorbid anxiety disorders and of substance use disorders in bipolar I disorder. Bipolar Disord. 2008;10(1):67–78.PubMedCrossRef
93.
Vieta E et al. Clinical correlates of psychiatric comorbidity in bipolar I patients. Bipolar Disord. 2001;3(5):253–8.PubMedCrossRef
94.
Frye MA et al. Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression. Am J Psychiatry. 2009;166(2):164–72.PubMedCrossRef
95.
Goldberg JF et al. Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD. Am J Psychiatry. 2007;164(9):1348–55.PubMedCrossRef
96.
Kohler S, Gaus S, Bschor T. The challenge of treatment in bipolar depression: evidence from clinical guidelines, treatment recommendations and complex treatment situations. Pharmacopsychiatry. 2014;47(2):53–9.PubMedCrossRef
97.
98.•
Perlis, R.H., C. Cusin, and M. Fava, Proposed DSM-5 mixed features are associated with greater likelihood of remission in out-patients with major depressive disorder. Psychol Med, 2012:1-7. The study focus on a post hoc analysis, comparing the outcome of major depressive patients with and without mixed features treated with antidepressants. Counterintuitively the Authors found a better outcome in patients with mixed features then in those without.
99.•
Pacchiarotti I et al. The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. Am J Psychiatry. 2013;170(11):1249–62. The article is a very comprehensive and updated review of the empirical evidence available on the controverse issue of the use of antidepressants in bipolar disorder.PubMedPubMedCentralCrossRef
100.••
Ostergaard SD et al. Rethinking the classification of mixed affective episodes in ICD-11. J Affect Disord. 2012;138(1-2):170–2. The article discuss the definition and the diagnostic role of mixed states. The authors conclude that a diagnostic category should be preferred to a specifier.PubMedCrossRef
101.
Koukopoulos A et al. Mixed depressive syndrome. Encephale. 1992;18(Spec No 1):19–21.PubMed
102.
Medda, P., Toni, C., Giorgi Mariani, M., De Simone, L., Mauri, M., Perugi, G., Electroconvulsive therapy (ECT) in 197 patients with severe, drug-resistant bipolar mixed state: treatment outcome and predictors of response. J Clin Psych. 2014.
Metadaten
Titel
The Significance of Mixed States in Depression and Mania
verfasst von
Giulio Perugi
Giuseppe Quaranta
Liliana Dell’Osso
Publikationsdatum
01.10.2014
Verlag
Springer US
Erschienen in
Current Psychiatry Reports / Ausgabe 10/2014
Print ISSN: 1523-3812
Elektronische ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-014-0486-4

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