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Erschienen in: Child's Nervous System 10/2018

13.07.2018 | Special Annual Issue

The spectrum of tuberculosis of the spine in pediatric age group: a review

verfasst von: Sandip Chatterjee, Aditya Banta

Erschienen in: Child's Nervous System | Ausgabe 10/2018

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Abstract

Introduction

Pediatric spinal tuberculosis is characterized by rapid bone destruction and carries the risk of rapid onset neurological deficits and severe deformity of the spine. Behavior of spinal deformity over time is affected by growth of spine. Owing to this dynamic behavior of pediatric spinal tuberculosis both in active phase and in healed phase, it presents with challenges which are quite different from adults with caries spine. A clinician must have high index of suspicion for accurate and early diagnosis of spinal tuberculosis in the pediatric population and should also have a thorough knowledge of differences in natural history between adult and pediatric spinal tuberculosis.

Discussion

This is based on the senior author’s experience of dealing with tuberculosis of the spine in children over the last two decades. Recent advances in field of rapid diagnosis of tuberculosis based on nuclear material-related diagnostic tests have further improved the management of tuberculosis. At the same time, the basic treatment principles remain the same. However, the threshold for surgical vs conservative treatment have subtle differences when compared to adult population. The importance of long-term follow-up after treatment must be appreciated.

Conclusion

Tuberculosis in the spine in children needs early attention. Prompting to diagnostic and medical therapy measures can avoid neurological sequellae and delayed deformity.
Literatur
1.
Zurück zum Zitat World Health Organization. Global tuberculosis report 2016 World Health Organization. Global tuberculosis report 2016
3.
4.
Zurück zum Zitat (1973) A controlled trial of ambulant out-patient treatment and in-patient rest in bed in the management of tuberculosis of the spine in young Korean patients on standard chemotherapy a study in Masan. Korea. First report of the Medical Research Council Working Party on Tuberculosis of the Spine. J Bone Joint Surg Br 55:678–697 (1973) A controlled trial of ambulant out-patient treatment and in-patient rest in bed in the management of tuberculosis of the spine in young Korean patients on standard chemotherapy a study in Masan. Korea. First report of the Medical Research Council Working Party on Tuberculosis of the Spine. J Bone Joint Surg Br 55:678–697
5.
Zurück zum Zitat (1974) A controlled trial of anterior spinal fusion and debridement in the surgical management of tuberculosis of the spine in patients on standard chemotherapy: a study in Hong Kong. Br J Surg 61:853–866 (1974) A controlled trial of anterior spinal fusion and debridement in the surgical management of tuberculosis of the spine in patients on standard chemotherapy: a study in Hong Kong. Br J Surg 61:853–866
6.
Zurück zum Zitat (1982) A 10-year assessment of a controlled trial comparing debridement and anterior spinal fusion in the management of tuberculosis of the spine in patients on standard chemotherapy in Hong Kong. Eighth Report of the Medical Research Council Working Party on Tuberculosis of the Spine. J Bone Joint Surg Br 64:393–398 (1982) A 10-year assessment of a controlled trial comparing debridement and anterior spinal fusion in the management of tuberculosis of the spine in patients on standard chemotherapy in Hong Kong. Eighth Report of the Medical Research Council Working Party on Tuberculosis of the Spine. J Bone Joint Surg Br 64:393–398
9.
Zurück zum Zitat Dimeglio A, Canavese F (2012) The growing spine: how spinal deformities influence normal spine and thoracic cage growth. Eur Spine J 21(1):64–70CrossRefPubMed Dimeglio A, Canavese F (2012) The growing spine: how spinal deformities influence normal spine and thoracic cage growth. Eur Spine J 21(1):64–70CrossRefPubMed
10.
12.
Zurück zum Zitat De Vuyst D, Vanhoenacker F, Gielen J et al (2003) Imaging features of musculoskeletal tuberculosis. Eur Radiol 13:1809–1819CrossRefPubMed De Vuyst D, Vanhoenacker F, Gielen J et al (2003) Imaging features of musculoskeletal tuberculosis. Eur Radiol 13:1809–1819CrossRefPubMed
13.
Zurück zum Zitat Tuli SM (2016) Tuberculosis of the skeletal system. JP Medical Ltd Tuli SM (2016) Tuberculosis of the skeletal system. JP Medical Ltd
14.
Zurück zum Zitat Hoffman EB, Crosier JH, Cremin BJ (1993) Imaging in children with spinal tuberculosis—a comparison of radiography, computed tomography and magnetic resonance imaging. JBJS 75B:233–239 Hoffman EB, Crosier JH, Cremin BJ (1993) Imaging in children with spinal tuberculosis—a comparison of radiography, computed tomography and magnetic resonance imaging. JBJS 75B:233–239
15.
Zurück zum Zitat Jain AK, Agarwal AN, Mehrotra G (1999) Correlation of canal encroachment with neurological deficit in tuberculosis of spine. Int Orthop 23(2):85–86CrossRefPubMedPubMedCentral Jain AK, Agarwal AN, Mehrotra G (1999) Correlation of canal encroachment with neurological deficit in tuberculosis of spine. Int Orthop 23(2):85–86CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Jain AK, Kumar J (2013) Tuberculosis of spine: neurological deficit. Eur Spine J 22(4):624–633CrossRefPubMed Jain AK, Kumar J (2013) Tuberculosis of spine: neurological deficit. Eur Spine J 22(4):624–633CrossRefPubMed
17.
Zurück zum Zitat Jain AK, Sinha S (2005) Evaluation of paraplegia grading systems in tuberculosis of the spine. Spinal Cord 43(6):375–380CrossRefPubMed Jain AK, Sinha S (2005) Evaluation of paraplegia grading systems in tuberculosis of the spine. Spinal Cord 43(6):375–380CrossRefPubMed
18.
Zurück zum Zitat Govender S, Ramnarain A, Danaviah S (2007) Cervical spine tuberculosis in children. Clin Orthop Relat Res 460:78–85CrossRefPubMed Govender S, Ramnarain A, Danaviah S (2007) Cervical spine tuberculosis in children. Clin Orthop Relat Res 460:78–85CrossRefPubMed
19.
20.
Zurück zum Zitat Rajasekaran S (2001) The natural history of post-tubercular kyphosis in children: radiological signs which predict late increase in deformity. Bone Joint J 83(7):954–962CrossRef Rajasekaran S (2001) The natural history of post-tubercular kyphosis in children: radiological signs which predict late increase in deformity. Bone Joint J 83(7):954–962CrossRef
21.
Zurück zum Zitat Cohn DL, O'Brien RJ, Geiter LJ, Rockville MD, Gordin FM, Hershfield E, Horsburgh CR Jr, Jereb JA, Jordan TJ, Kaplan JE, Nolan CM (2000) Targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med 161(4):221–247 Cohn DL, O'Brien RJ, Geiter LJ, Rockville MD, Gordin FM, Hershfield E, Horsburgh CR Jr, Jereb JA, Jordan TJ, Kaplan JE, Nolan CM (2000) Targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med 161(4):221–247
22.
Zurück zum Zitat Horsburgh CR Jr (2004) Priorities for the treatment of latent tuberculosis infection in the United States. N Engl J Med 350(20):2060–2067CrossRefPubMed Horsburgh CR Jr (2004) Priorities for the treatment of latent tuberculosis infection in the United States. N Engl J Med 350(20):2060–2067CrossRefPubMed
24.
Zurück zum Zitat Walls T, Shingadia D (2004) Global epidemiology of paediatric tuberculosis. J Infect 48(1):13–22CrossRefPubMed Walls T, Shingadia D (2004) Global epidemiology of paediatric tuberculosis. J Infect 48(1):13–22CrossRefPubMed
25.
Zurück zum Zitat International Union Against Tuberculosis Committee on Prophylaxis (1982) Efficacy of various durations of isoniazid preventive therapy for tuberculosis: five years of follow-up in the IUAT trial. Bull World Health Organ 60(4):555PubMedCentral International Union Against Tuberculosis Committee on Prophylaxis (1982) Efficacy of various durations of isoniazid preventive therapy for tuberculosis: five years of follow-up in the IUAT trial. Bull World Health Organ 60(4):555PubMedCentral
26.
Zurück zum Zitat Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, O’Brien RJ (2017) Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention clinical practice guidelines: diagnosis of tuberculosis in adults and children. Clin Infect Dis 64(2):e1–e33 5CrossRefPubMed Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, O’Brien RJ (2017) Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention clinical practice guidelines: diagnosis of tuberculosis in adults and children. Clin Infect Dis 64(2):e1–e33 5CrossRefPubMed
27.
Zurück zum Zitat Malakmadze N, González IM, Oemig T, Isiadinso I, Rembert D, McCauley MM, Wand P, Diem L, Cowan L, Palumbo GJ, Fraser M (2005) Unsuspected recent transmission of tuberculosis among high-risk groups: implications of universal tuberculosis genotyping in its detection. Clin Infect Dis 40(3):366–373CrossRefPubMed Malakmadze N, González IM, Oemig T, Isiadinso I, Rembert D, McCauley MM, Wand P, Diem L, Cowan L, Palumbo GJ, Fraser M (2005) Unsuspected recent transmission of tuberculosis among high-risk groups: implications of universal tuberculosis genotyping in its detection. Clin Infect Dis 40(3):366–373CrossRefPubMed
28.
Zurück zum Zitat Kimerling ME, Benjamin WH, Lok KH, Curtis G, Dunlap NE (1998) Restriction fragment length polymorphism screening of Mycobacterium tuberculosis isolates: population surveillance for targeting disease transmission in a community. Int J Tuberc Lung Dis 2(8):655–662PubMed Kimerling ME, Benjamin WH, Lok KH, Curtis G, Dunlap NE (1998) Restriction fragment length polymorphism screening of Mycobacterium tuberculosis isolates: population surveillance for targeting disease transmission in a community. Int J Tuberc Lung Dis 2(8):655–662PubMed
29.
Zurück zum Zitat Behr MA, Small PM (1997) Molecular fingerprinting of Mycobacterium tuberculosis: how can it help the clinician? Clin Infect Dis 25(4):806–810CrossRefPubMed Behr MA, Small PM (1997) Molecular fingerprinting of Mycobacterium tuberculosis: how can it help the clinician? Clin Infect Dis 25(4):806–810CrossRefPubMed
30.
Zurück zum Zitat Moore SL, Rafi M (2001) Imaging of musculoskeletal and spinal tuberculosis. Radiol Clin N Am 39:329–342CrossRefPubMed Moore SL, Rafi M (2001) Imaging of musculoskeletal and spinal tuberculosis. Radiol Clin N Am 39:329–342CrossRefPubMed
31.
Zurück zum Zitat Gard RK, Somvanshi DS (2011) Spinal tuberculosis: a review. J Spinal Cord Med 34:440–454CrossRef Gard RK, Somvanshi DS (2011) Spinal tuberculosis: a review. J Spinal Cord Med 34:440–454CrossRef
32.
Zurück zum Zitat Guo LX, Ma YZ, Chen X, Bao D, Luo XB (2010) Clinical study of short course chemotherapy in spinal tuberculosis. Zhogguo Gu Shang 23:491–494 Guo LX, Ma YZ, Chen X, Bao D, Luo XB (2010) Clinical study of short course chemotherapy in spinal tuberculosis. Zhogguo Gu Shang 23:491–494
33.
Zurück zum Zitat Kotil K, Alan MS (2007) Medical management of Pott disease in thoracic and lumbar spine: a prospective clinical study. J Neurosurg Spine 6:222–228CrossRefPubMed Kotil K, Alan MS (2007) Medical management of Pott disease in thoracic and lumbar spine: a prospective clinical study. J Neurosurg Spine 6:222–228CrossRefPubMed
34.
Zurück zum Zitat Parthasarthy R, Sriram K, Santha T (1999) Short course chemotherapy for tuberculosis of spine—a comparison between treatment and radical surgery. J Bone Joint Surg Br 81:464–471CrossRef Parthasarthy R, Sriram K, Santha T (1999) Short course chemotherapy for tuberculosis of spine—a comparison between treatment and radical surgery. J Bone Joint Surg Br 81:464–471CrossRef
35.
Zurück zum Zitat Mak KC, Cheung KM (2013) Surgical treatment of acute TB spondylitis: indications and outcomes. Eur Spine J 22(4):603–611CrossRefPubMed Mak KC, Cheung KM (2013) Surgical treatment of acute TB spondylitis: indications and outcomes. Eur Spine J 22(4):603–611CrossRefPubMed
36.
Zurück zum Zitat Tuli SM (1975) Results of treatment of spinal tuberculosis by “middle-path” regime. J Boone Joint Surg (Br) 57B:13–23CrossRef Tuli SM (1975) Results of treatment of spinal tuberculosis by “middle-path” regime. J Boone Joint Surg (Br) 57B:13–23CrossRef
37.
Zurück zum Zitat Kumar R, Srivastava AK, Tiwari RK (2011) Surgical management of Pott’s disease of the spine in pediatric patients: a single surgeon’s experience of 8 years in a tertiary care center. J PediatrNeurosci 6(Suppl 1):S101–S108 Kumar R, Srivastava AK, Tiwari RK (2011) Surgical management of Pott’s disease of the spine in pediatric patients: a single surgeon’s experience of 8 years in a tertiary care center. J PediatrNeurosci 6(Suppl 1):S101–S108
38.
Zurück zum Zitat Chatterjee S, Basu S (2003) Trans sternal decompression of postlaminectomy caries of the upper dorsal spine. Br J Neurosurg 17(3):270–271CrossRefPubMed Chatterjee S, Basu S (2003) Trans sternal decompression of postlaminectomy caries of the upper dorsal spine. Br J Neurosurg 17(3):270–271CrossRefPubMed
39.
Zurück zum Zitat Jain AK, Maheshwari AV, Jena S (2007) Kyphus correction in spinal tuberculosis. Clin Orthop Relat Res 460:117–123CrossRefPubMed Jain AK, Maheshwari AV, Jena S (2007) Kyphus correction in spinal tuberculosis. Clin Orthop Relat Res 460:117–123CrossRefPubMed
40.
Zurück zum Zitat Laheri VJ, Badhe NP, Dewnany GT (2001) Single stage decompression, anterior interbody fusion and posterior instrumentation for tuberculous kyphosis of the dorso-lumbar spine. Spinal Cord 39:429–436CrossRefPubMed Laheri VJ, Badhe NP, Dewnany GT (2001) Single stage decompression, anterior interbody fusion and posterior instrumentation for tuberculous kyphosis of the dorso-lumbar spine. Spinal Cord 39:429–436CrossRefPubMed
41.
Zurück zum Zitat Bezer M, Kucukdurmaz F, Guven O (2007) Transpedicular decancellation osteotomy in the treatment of posttuberculous kyphosis. J Spinal Disord Tech 20:209–215CrossRefPubMed Bezer M, Kucukdurmaz F, Guven O (2007) Transpedicular decancellation osteotomy in the treatment of posttuberculous kyphosis. J Spinal Disord Tech 20:209–215CrossRefPubMed
42.
Zurück zum Zitat Moon MS, Woo YK, Lee KS, Ha KY, Kim SS, Sun DH (1995) Posterior instrumentation and anterior interbody fusion for tuberculous kyphosis of dorsal and lumbar spines. Spine 20:1910–1916CrossRefPubMed Moon MS, Woo YK, Lee KS, Ha KY, Kim SS, Sun DH (1995) Posterior instrumentation and anterior interbody fusion for tuberculous kyphosis of dorsal and lumbar spines. Spine 20:1910–1916CrossRefPubMed
43.
Zurück zum Zitat Moon MS (1999) Tuberculosis of the spine-controversies and a new challenge. Spine 22:1791–1797CrossRef Moon MS (1999) Tuberculosis of the spine-controversies and a new challenge. Spine 22:1791–1797CrossRef
Metadaten
Titel
The spectrum of tuberculosis of the spine in pediatric age group: a review
verfasst von
Sandip Chatterjee
Aditya Banta
Publikationsdatum
13.07.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Child's Nervous System / Ausgabe 10/2018
Print ISSN: 0256-7040
Elektronische ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-018-3891-x

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