How is functional chronic constipation defined?
Must include for 1 month at least two of the following in infants up to 4 years of age: |
- Two or fewer defecations per week; |
- History of excessive stool retention; BLUE |
- History of painful or hard bowel movements; |
- History of large diameter stools; BLUE |
- Presence of a large fecal mass in the rectum. |
In toilet-trained children, the following additional criteria may be used: |
- At least one episode/week of fecal incontinence after the acquisition of toileting skills; |
- History of large-diameter stools that may obstruct the toilet.BLUE |
Must include 2 or more of the following occurring at least once per week for a minimum of 1 month with insufficient criteria for a diagnosis of irritable bowel syndrome in children older than 4 years: |
- 2 or fewer defecations in the toilet per week in a child of a developmental age of at least 4 years BLUE |
- At least 1 episode of fecal incontinence per week |
- History of retentive posturing or excessive volitional stool retention BLUE |
- History of painful or hard bowel movements |
- Presence of a large fecal mass in the rectum BLUE |
- History of large diameter stools that can obstruct the toilet. |
What is the incidence?
What is the etiology?
Which are the signs and symptoms of functional constipation?
What is the differential diagnosis?
- Delayed meconium passage |
- Onset of symptoms <1 month |
- Starting in neonatal period |
- Ribbon stools |
- Absent anal/cremasteric reflex |
- Blood in the stools in the absence of anal fissures |
- Failure to thrive or weight loss |
- Abdominal distension |
- Bilious vomiting |
- Abnormal position of anus |
- Tuft of hair on spine |
- Deep sacral dimple |
- Alteration lower extremity strength/tone/reflex |
What pharmacological treatments are recommended for disimpaction?
Oral Laxatives | Dosages |
---|---|
Osmotic Laxatives | |
PEG 3350/4000 WHITE | All age groups: Maintenance: 0.2–0.8 g/kg/day in 1–2 doses Fecal disimpaction: 1–1.5 g/kg/day (maximum 6 days) |
Lactulose | All age groups: 1–2 g/kg/day, in 1–2 doses |
Lactitol WHITE | 1–6 years: 0.5–1 g/kg/day in 2–3 doses 6–12 years: 10–30 g/day in 2–3 doses 12–18 years: 20–60 g/day in 2–3 doses |
Magnesium hydroxide | 2–5 years: 0.4–1.2 g/day, in 1 or more doses 6–11 years: 1.2–2.4 g/day, in 1 or more doses 12–18 years: 2.4–4.8 g/day, in 1 or more doses |
Stimulant Laxatives WHITE | |
Bisacodyl | 3–10 years: 5 mg/day, in 1 dose/day (at night) 10–11 years: 5–10 mg/day, in 1 dose/day (at night) 12–18 years: 5–15 mg/day, in 1 dose/day (at night) |
Senna WHITE | 2–6 years: 2.5–5 mg, 1 or 2 doses/day 6–11 years: 7.5–10 mg, 1 dose/day 12–18 years: 15–20 mg, 1 dose/day |
Sodium picosulfate | 1 month to 4 years: 2.5–10 mg/day, in 1 dose/day 4–18 years: 2.5–20 mg/day, in 1 dose/day |
Rectal Laxatives DARK BLUE | Dosages |
Bisacodyl | 2–10 years: 5 mg/day, in 1 dose/day (at night) > 10 years: 5–10 mg/day, in 1 dose/day (at night) |
Sodium lauryl sulfoacetate WHITE | 1 month to 1 year: 2.5 mL/dose (= 0.5 enema) 1–18 years: 5 mL/dose (= 1 enema) |
Sodium docusate | < 6 years: 60 mL > 6 years: 120 mL |
Sodium phosphate | 1–18 y: 2.5 mL/kg, max 133 mL/dose |
Oral and rectal laxatives DARK BLUE | Dosages |
Mineral oil/liquid paraffin WHITE | 2–11 years: 30–60 mL, in 1 dose/day > 11 years: 60–150 mL, in 1 dose/day |
3–18 years: 1–3 mL/kg/day, 1 or more doses/day (maximum 90 mL/day) |