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Intensive Care Medicine

Erschienen in:

01.04.2015 | What's New in Intensive Care

The tens of thousands of lives saved by randomized clinical trials in critical care

verfasst von: Gordon S. Doig, Ian Roberts, Rinaldo Bellomo

Erschienen in: Intensive Care Medicine | Ausgabe 4/2015

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Excerpt

In the second half of 1952, a total of 2,722 patients with poliomyelitis were admitted to the Blegdam Hospital for communicable diseases in Copenhagen. With 12 % of all admissions requiring artificial respiratory support, resources were soon overwhelmed, and the initial case-fatality rate for patients with respiratory failure reached 90 %. Driven by necessity, a few dedicated professionals persisted with “therapeutic improvisations” and eventually refined the specific skills required to provide long-term manual positive pressure ventilation through a tracheostomy [1]. Because of excellent record keeping, subsequent publications demonstrated that manual positive pressure ventilation halved the case-fatality rate [2]. …

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Levy MM, Rhodes A, Phillips GS, Townsend SR, Schorr CA, Beale R et al (2014) Surviving sepsis campaign: association between performance metrics and outcomes in a 7.5-year study. Intensiv Care Med 40:1623–1633CrossRef

Roberts I, Yates D, Sandercock P, Farrell B, Wasserberg J, Lomas G et al (2004) Effect of intravenous corticosteroids on death within 14 days in 10,008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 364:1321–1328CrossRefPubMed

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Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S et al (2009) Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med 361:1627–1638CrossRefPubMed

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Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lee J et al (2012) An observational study fluid balance and patient outcomes in the randomized evaluation of normal vs. augmented level of replacement therapy trial. Crit Care Med 40:1753–1760CrossRefPubMed

Titel: The tens of thousands of lives saved by randomized clinical trials in critical care
verfasst von: Gordon S. Doig
Ian Roberts
Rinaldo Bellomo
Publikationsdatum: 01.04.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 4/2015
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-014-3573-4

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