Erschienen in:
05.08.2017 | Concise Commentary
Therapeutic Potential of the Gabaergic System in Ulcerative Colitis: Current Status and Perspectives
verfasst von:
Maria Grazia Zizzo, Rosa Serio
Erschienen in:
Digestive Diseases and Sciences
|
Ausgabe 10/2017
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Excerpt
An extensive body of literature supports the physiological and pathological importance of γ-amino butyric acid (GABA)ergic signalling in the gut. Although the functional significance of GABA in the gastrointestinal tract is still a matter of debate, GABA may contribute to the “neuroimmune dialogue” between the enteric nervous system and the intestinal mucosal immune system during inflammatory events [
1] such as with the prototypic gut inflammatory disease, inflammatory bowel disease (IBD). …