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Neurological Sciences

Erschienen in:

01.06.2011 | Original Article

Therapeutic time window for the neuroprotective effects of NGF when administered after focal cerebral ischemia

verfasst von: Ji-Ping Yang, Huai-Jun Liu, Hua Yang, Ping-Yong Feng

Erschienen in: Neurological Sciences | Ausgabe 3/2011

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Abstract

In the present study, we evaluated the neuroprotection time window for nerve growth factor (NGF) after ischemia/reperfusion brain injury in rabbits as related to this anti-apoptosis mechanism. Male New Zealand rabbits were subjected to 2 h of middle cerebral artery occlusion (MCAO), followed by 70 h of reperfusion. NGF was administered after injury to evaluate the time window. Neurological deficits, infarct volume, neural cell apoptosis and expressions of caspase-3 and Bcl-2 were measured. Compared to saline-treated control, NGF treatment at 2, 3 and 5 h after MCAO significantly reduced infarct volume, neural cell apoptosis and expression of caspase-3 (P < 0.01), up-regulated the expression of Bcl-2 and improved functional recovery (P < 0.01). However, treatment at latter time points did not produce significant neuroprotection. Neuroprotection treatment with NGF provides an extended time window of up to 5 h after ischemia/reperfusion brain injury, in part by attenuating the apoptosis.

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Titel: Therapeutic time window for the neuroprotective effects of NGF when administered after focal cerebral ischemia
verfasst von: Ji-Ping Yang
Huai-Jun Liu
Hua Yang
Ping-Yong Feng
Publikationsdatum: 01.06.2011
Verlag: Springer Milan
Erschienen in: Neurological Sciences / Ausgabe 3/2011
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-011-0512-9

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