nach oben

Erschienen in:

14.03.2017 | Original Paper

Theta Burst Stimulation of the Precuneus Modulates Resting State Connectivity in the Left Temporal Pole

verfasst von: Matteo Mancini, Chiara Mastropasqua, Sonia Bonnì, Viviana Ponzo, Mara Cercignani, Silvia Conforto, Giacomo Koch, Marco Bozzali

Erschienen in: Brain Topography | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

It has been shown that continuous theta burst stimulation (cTBS) over the precuneus acts on specific memory retrieval abilities. In order to study the neural mechanisms beyond these findings, we combined cTBS and resting-state functional magnetic resonance imaging. Our experimental protocol involved stimulation and sham conditions on a group of healthy subjects, and each condition included a baseline and two follow-up acquisitions (5 and 15 min after baseline) after cTBS. We analysed brain functional connectivity by means of graph theoretical measures, with a specific focus on the network modular structure. Our results showed that cTBS of the precuneus selectively affects the left temporal pole, decreasing its functional connectivity in the first follow-up. Moreover, we observed a significant increase in the size of the module of the precuneus in the second follow-up. Such effects were absent in the sham condition. We observed here a modulation of functional connectivity as a result of inhibitory stimulation over the precuneus. Such a modulation first acts indirectly on the temporal area and then extends the connectivity of the precuneus itself by a feed-back mechanism. Our current findings extend our previous behavioural observations and increase our understanding of the mechanisms underlying the stimulation of the precuneus.

Nur mit Berechtigung zugänglich

Achard S, Bullmore E (2007) Efficiency and cost of economical brain functional networks. PLoS Comput Biol 3(2) 174–183CrossRef

Aertsen AM, Gerstein GL (1985) Evaluation of neuronal connectivity: sensitivity of cross-correlation. Brain Res 340:341–354CrossRefPubMed

Bassett DS, Wymbs NF, Porter MA, Mucha PJ, Carlson JM, Grafton ST (2011) Dynamic reconfiguration of human brain networks during learning. Proc Natl Acad Sci USA 108(18):7641–7646CrossRefPubMedPubMedCentral

Bassett DS, Wymbs NF, Rombach MP, Porter MA, Mucha PJ Grafton ST (2013) Task-based core-periphery organisation of human brain dynamics. PLoS Comput Biol 9(9) 1–16CrossRef

Benjamini Y, Yekutieli D (2001) The control of the false discovery rate in multiple testing under dependency. Ann Stat 29(4):1165–1188CrossRef

Blaizot X, Mansilla F, Insausti AM, Constans JM, Salinas-Alamán A, Pró-Sistiaga P, Mohedano-Moriano A, Insausti R (2010) The human parahippocampal region: I. Temporal pole cytoarchitectonic MRI correlation. Cereb Cortex 20(9):2198–2212CrossRefPubMedPubMedCentral

Bonnì S, Veniero D, Mastropasqua C, Ponzo V, Caltagirone C, Bozzali M, Koch G (2015) TMS evidence for a selective role of the precuneus in source memory retrieval. Behav Brain Res 282:70–75CrossRefPubMed

Braun U, Schaefer A, Walter H, Erk S, Romanczuk-Seiferth N, Haddad L, Schweiger J, Grimm O, Heinz A, Tost H, Meyer-Lindenberg A, Bassett DS (2015) Dynamic reconfiguration of frontal brain networks during executive cognition in humans. Proc Natl Acad Sci USA 112(37):11678–11683CrossRefPubMedPubMedCentral

Bullmore E, Sporns O (2009) Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10:186–198CrossRefPubMed

Bullmore E, Fadili J, Maxim V, Sendur L, Whitcher B, Suckling J, Brammer M, Breakspear M (2004) Wavelets and functional magnetic resonance imaging of the human brain. Neuroimage 23:S234–S249CrossRefPubMed

Cavanna AE, Trimble MR (2006) The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129:564–583CrossRefPubMed

Chai LR, Mattar MG, Blank IA, Fedorenko E, Bassett DS (2016) Functional network dynamics of the language system. Cereb Cortex 26(11):4148–4159CrossRefPubMedCentral

Cocchi L, Sale MV, Lord A, Zalesky A, Breakspear M, Mattingley JB (2015) Dissociable effects of local inhibitory and excitatory theta-burst stimulation on large-scale brain dynamics. J Neurophysiol 113:3375–3385CrossRefPubMedPubMedCentral

Cocchi L, Sale MV, Gollo LL, Bell PT, Nguyen VT, Zalesky A, Breakspear M, Mattingley JB (2016) A hierarchy of timescales explains distinct effects of local inhibition of primary visual cortex and frontal eye fields. Elife 5:1–17CrossRef

Cox RW (1996) AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29(3):162–173CrossRefPubMed

Daselaar SM, Prince SE, Dennis NA, Hayes SM, Kim H, Cabeza R (2009) Posterior midline and ventral parietal activity is associated with retrieval success and encoding failure. Front Hum Neurosci 3(13):1–10

Deco G, Jirsa VK, McIntosh AR (2011) Emerging concepts for the dynamical organization of resting-state activity in the brain. Nat Rev Neurosci 12:43–56CrossRefPubMed

Desikan RS, Segonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT, Albert MS, Killiany RJ (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31:968–980CrossRefPubMed

Donaldson DI, Wheeler ME, Petersen SE (2010) Remember the source: dissociating frontal and parietal contributions to episodic memory. J Cogn Neurosci 22(2):377–391CrossRefPubMed

Doron KW, Bassett DS, Gazzaniga MS (2012) Dynamic network structure of interhemispheric coordination. Proc Natl Acad Sci USA 109(46):18661–18668CrossRefPubMedPubMedCentral

Fallani, FDV, Richiardi J, Chavez M, Achard S (2014) Graph analysis of functional brain networks: practical issues in translational neuroscience. Philos Trans R Soc B 369(1653):1–36

Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33:341–355CrossRefPubMed

Fisher RA, (1935) The design of experiments. Hafner, New York

Fornito A, Harrison BJ, Zalesky A, Simons JS (2012) Competitive and cooperative dynamics of large-scale brain functional networks supporting recollection. Proc Natl Acad Sci USA 109(31):12788–12793CrossRefPubMedPubMedCentral

Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700–711CrossRefPubMed

Fox MD, Halko MA, Eldaief MC, Pascual-Leone A (2012a) Measuring and manipulating brain connectivity with resting state functional connectivity magnetic resonance imaging (fcMRI) and transcranial magnetic stimulation (TMS). Neuroimage 62:2232–2243CrossRefPubMedPubMedCentral

Fox MD, Liu H, Pascual-Leone A (2012b) Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity. Neuroimage 66C:151–160

Fox MD, Buckner RL, Liu H, Chakavarty MM, Lozano AM, Pascual-Leone A (2014) Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological disease. Proc Natl Acad Sci USA 111(41):E4367–E4375CrossRefPubMedPubMedCentral

Friston KJ, Frith CD, Frackowiak RS (1993) Principal component analysis learning algorithms: a neurobiological analysis. Proc Biol Sci 254:47–54CrossRefPubMed

Gabrowsky TJ, Damasio H, Tranel D, Cooper GE, Ponto LLB Watkins GL, Hichwa RD (2003) Residual naming after damage to the left temporal pole: a PET activation study. Neuroimage 19:846–860CrossRef

Gallassi R, Sambati L, Poda R, Maserati MS, Oppi F, Giulioni M, Tinuper P (2011) Accelerated long-term forgetting in temporal lobe epilepsy: evidence of improvement after left temporal pole lobectomy. Epilepsy Behav 22:793–795CrossRefPubMed

Gallos LK, Makse HA, Sigman M (2012) A small world of weak ties provides optimal global integration of self-similar modules in functional brain networks. Proc Natl Acad Sci USA 109(8):2825–2830CrossRefPubMedPubMedCentral

Gratton C, Lee TG, Nomura EM, D’Esposito M (2013) The effect of theta-burst TMS on cognitive control networks measured with resting state fMRI. Front Syst Neurosci 7(124):1–14

Guimerà R, Amaral LAN (2005) Functional cartography of complex metabolic networks. Nature 433:895–900CrossRefPubMedPubMedCentral

Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC (2005) Theta burst stimulation of the human motor cortex. Neuron 45:201–206CrossRefPubMed

Huijbers W, Vannini P, Sperling RA, Pennartz CM, Cabeza R, Daselaar SM (2012) Explaining the encoding/retrieval flip: memory-related deactivations and activations in the posteromedial cortex. Neuropsychologia 50(14):3764–3774CrossRefPubMed

Hutchinson JB, Uncapher MR, Wagner AD (2009) Posterior parietal cortex and episodic retrieval: convergent and divergent effects of attention and memory. Learn Mem 16(6):343–356CrossRefPubMedPubMedCentral

Koch G, Del Olmo MF, Cheeran B et al (2007) Focal stimulation of the posterior parietal cortex increases the excitability of the ipsilateral motor cortex. J Neurosci 27:6815–6822CrossRefPubMed

Liston C, Chen AC, Zebley BD, Drysdale AT, Gordon R, Leuchter B, Voss HU, Casey BJ, Etkin A, Dubin MJ (2014) Default mode network mechanisms of transcranial magnetic stimulation in depression. Biol Psychiatry 76(7):517–526CrossRefPubMedPubMedCentral

Luft C, Pereda E, Banissy MJ, Bhattacharya J (2014) Best of both worlds: promise of combining brain stimulation and brain connectome. Front Syst Neurosci 8(132):1–15

Maguire EA, Mummery CJ, Büchel C (2000) Patterns of hippocampal–cortical interaction dissociate temporal lobe memory subsystems. Hippocampus 10(4):475–482CrossRefPubMed

Mastropasqua C, Bozzali M, Ponzo V, Giulietti G, Caltagirone C, Cercignani M, Koch G (2014) Network based statistical analysis detects changes induced by continuous theta-burst stimulation on brain activity at rest. Front Psychiatry 5(97):1–7

Newman MEJ (2006) Finding community structure in networks using the eigenvectors of matrices. Phys Rev E 74:1–22CrossRef

Pobric G, Ralph MAL, Jeffries E (2009) The role of the anterior temporal lobes in the comprehension of concrete and abstract words: rTMS evidence. Cortex 45:1104–1110CrossRefPubMedPubMedCentral

Ranieri F, Ferraccioli M, Bassi MS, Musumeci G, Di Lazzaro V, Gainotti G, Marra C (2015) Familiarity for famous faces and names is not equally subtended by the right and left temporal poles: evidence from an rTMS study. Neurobiol Learn Mem 125:15–23CrossRefPubMed

Rubinov M, Sporns O (2010) Complex network measures of brain connectivity: uses and interpretations. Neuroimage 52:1059–1069CrossRefPubMed

Sale MV, Mattingley JB, Zalesky A, Cocchi L (2015) Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation. Neurosci Behav Rev 57:187–198CrossRef

Serra, L., Mancini, M., Silvestri, G., et al., (2016a) Brain connectomics’ modification to clarify motor and nonmotor features of myotonic dystrophy type 1. Neural Plast. doi:10.1155/2016/2696085 PubMedPubMedCentral

Serra L, Cercignani M, Bruschini M, Cipolotti L, Mancini M, Silvestri G et al (2016b) “I know that you know that I know”: neural substrates associated with social cognition deficits in DM1 patients. PLoS ONE 11(6):e0156901CrossRefPubMedPubMedCentral

Shipton OA, El-Gaby M, Apergis-Schoute J, Disseroth K, Bannerman DM, Paulsen O, Kohl MM (2014) Left-right dissociation of hippocampal memory processes in mice. Proc Natl Acad Sci USA 111(42):15238–15243CrossRefPubMedPubMedCentral

Sporns O. (2015) Cerebral cartography and connectomics. Philos Trans B 370(1668): 1–12CrossRef

Sporns O, Betzel RF (2016) Modular nrain networks. Annu Rev Psychol 67:613–640CrossRefPubMed

Stokes MG, Chambers CD, Gould IC, Henderson TR, Janko NE, Allen NB, Mattingley JB (2005) Simple metric for scaling motor threshold based on scalp-cortex distance: application to studies using transcranial magnetic stimulation. J Neurophysiol 94(6):4520–4527CrossRefPubMed

Turriziani P, Smirni D, Zappalà G, Mangano GR, Oliveri M, Cipolotti L (2012) Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex. Front Hum Neurosci 6(62):1–8

van Wijk, BCM, Stam, CJ, Daffertshofer, A, (2010) Comparing brain networks of different size and connectivity density using graph theory. PLoS ONE 5(10):1–13

van den Heuvel MP, Hulshoff Pol HE (2010) Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol 20:519–534CrossRefPubMed

van den Heuvel MP, Sporns O (2011) Rich-club organization of the human connectome. J Neurosci 31(44):15775–15786CrossRefPubMed

van den Heuvel MP, Sporns O (2013a) Network hubs in the human brain. Trends Cogn Sci 17(12):683–696CrossRefPubMed

van den Heuvel MP, Sporns O (2013b) An anatomical substrate for integration among functional networks in human cortex. J Neurosci 33(36):14489–14500CrossRefPubMed

Wagner AD, Shannon BJ, Kahn L, Buckner RL (2005) Parietal lobe contributions to episodic memory retrieval. Trends Cogn Sci 9:445–453CrossRefPubMed

Zanto TP, Rubens MT, Thangavel A, Gazzaley A (2011) Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory. Nat Neurosci 14:656–661CrossRefPubMedPubMedCentral

Titel: Theta Burst Stimulation of the Precuneus Modulates Resting State Connectivity in the Left Temporal Pole
verfasst von: Matteo Mancini
Chiara Mastropasqua
Sonia Bonnì
Viviana Ponzo
Mara Cercignani
Silvia Conforto
Giacomo Koch
Marco Bozzali
Publikationsdatum: 14.03.2017
Verlag: Springer US
Erschienen in: Brain Topography / Ausgabe 3/2017
Print ISSN: 0896-0267
Elektronische ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-017-0559-x

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Bluttest erkennt Parkinson schon zehn Jahre vor der Diagnose

10.05.2024 Parkinson-Krankheit Nachrichten

Ein Bluttest kann abnorm aggregiertes Alpha-Synuclein bei einigen Menschen schon zehn Jahre vor Beginn der motorischen Parkinsonsymptome nachweisen. Mit einem solchen Test lassen sich möglicherweise Prodromalstadien erfassen und die Betroffenen früher behandeln.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Wartezeit nicht kürzer, aber Arbeit flexibler

Psychotherapie Medizin aktuell

Fünf Jahren nach der Neugestaltung der Psychotherapie-Richtlinie wurden jetzt die Effekte der vorgenommenen Änderungen ausgewertet. Das Hauptziel der Novellierung war eine kürzere Wartezeit auf Therapieplätze. Dieses Ziel wurde nicht erreicht, es gab jedoch positive Auswirkungen auf andere Bereiche.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2017

Brain Areas Responsible for Vigilance: An EEG Source Imaging Study

Whole-Brain High-Resolution Structural Connectome: Inter-Subject Validation and Application to the Anatomical Segmentation of the Striatum

Prior Visual Experience Modulates Learning of Sound Localization Among Blind Individuals

Cerebellar Involvement in Patients with Mild to Moderate Myoclonus Due to EPM1: Structural and Functional MRI Findings in Comparison with Healthy Controls and Ataxic Patients

Neurophysiological Correlates of Attentional Fluctuation in Attention-Deficit/Hyperactivity Disorder