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Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

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19.05.2021 | Original Article

Three-dimensional imaging and molecular analysis of the effects of photobiomodulation and mechanical vibration on orthodontic retention treatment in rats

Effects of photobiomodulation and mechanical vibration on orthodontic retention treatment

verfasst von: Taner Öztürk, DDS, MDS, Nisa Gül Amuk, DDS, PhD

Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie | Sonderheft 1/2022

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Abstract

Purpose

We aimed to evaluate and compare effects of photobiomodulation (PBM) and low-magnitude high-frequency mechanical vibration (HFMV) on orthodontic retention.

Methods

Sixty-four female Wistar albino rats were divided into 9 groups (2 negative and positive controls each, 3 PBM and 2 HFMV groups) and studied for 25 days. In the experimental groups, closed nickel–titanium closed coil springs with a 50 cN force were placed for 10 days between the maxillary incisor and molar. PBM and HFMV were applied daily over long- (15 days) and short-term (7 days) retention periods. The PBM groups received PBM with a single wavelength (650 nm) or higher wavelengths (532, 650, 940 nm) for 9 min per day. HFMV groups received HFMV of 10, 20, and 30 Hz for 10 min per day. Right and left maxilla were assessed using micro-computed tomography imaging and real-time polymerase chain reaction. The amount of tooth movement during the retention period, expression levels of cyclooxygenase‑2 (COX-2), osteoprotegerin (OPG), and receptor activator of nuclear factor-kappa B ligand (RANKL) mRNA gene expression levels, OPG/RANKL ratios, alveolar bone trabecular thickness (Tb.Th), trabecular number (Tb.N), and structure model index were analyzed. Kruskal–Wallis and Mann–Whitney U tests were used for multiple comparisons of the nonparametric distributed data and binary comparisons, respectively.

Results

When using the long-term retention protocol, PBM and HFMV treatment increased Tb.N (p < 0.05) and decreased COX‑2 mRNA gene expression levels (p < 0.05) and Tb.Th (p < 0.05) compared to controls. For short-term retention, PBM and HFMV decreased the amount of relapse tooth movement compared to controls. In addition, Tb.Th (p < 0.05) and the mRNA gene expression levels of COX‑2 and RANKL (p < 0.05) were decreased.

Conclusion

PBM and HFMV might be able to support retention after orthodontic tooth movement by reducing bone resorption and increasing bone quality.

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Titel: Three-dimensional imaging and molecular analysis of the effects of photobiomodulation and mechanical vibration on orthodontic retention treatment in rats
Effects of photobiomodulation and mechanical vibration on orthodontic retention treatment
verfasst von: Taner Öztürk, DDS, MDS
Nisa Gül Amuk, DDS, PhD
Publikationsdatum: 19.05.2021
Verlag: Springer Medizin
Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie / Ausgabe Sonderheft 1/2022
Print ISSN: 1434-5293
Elektronische ISSN: 1615-6714
DOI: https://doi.org/10.1007/s00056-021-00296-0

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Three-dimensional imaging and molecular analysis of the effects of photobiomodulation and mechanical vibration on orthodontic retention treatment in rats

Effects of photobiomodulation and mechanical vibration on orthodontic retention treatment

Abstract

Purpose

Methods

Results

Conclusion

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