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01.10.2014 | Original Contribution

Three-month B vitamin supplementation in pre-school children affects folate status and homocysteine, but not cognitive performance

verfasst von: Astrid Rauh-Pfeiffer, Uschi Handel, Hans Demmelmair, Wolfgang Peissner, Mareile Niesser, Diego Moretti, Vanessa Martens, Sheila Wiseman, Judith Weichert, Moritz Heene, Markus Bühner, Berthold Koletzko

Erschienen in: European Journal of Nutrition | Ausgabe 7/2014

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Abstract

Background

Suboptimal vitamin B status might affect cognitive performance in early childhood. We tested the hypothesis that short-term supplementation with folic acid and selected B vitamins improves cognitive function in healthy children in a population with relatively low folate status.

Methods

We screened 1,002 kindergarten children for suboptimal folate status by assessing the total urinary para-aminobenzoylglutamate excretion. Two hundred and fifty low ranking subjects were recruited into a double blind, randomized, controlled trial to receive daily a sachet containing 220 μg folic acid, 1.1 mg vitamin B₂, 0.73 mg B₆, 1.2 μg B₁₂ and 130 mg calcium, or calcium only for 3 months. Primary outcomes were changes in verbal IQ, short-term memory and processing speed between baseline and study end. Secondary outcomes were urinary markers of folate and vitamin B₁₂ status, acetyl-para-aminobenzoylglutamate and methylmalonic acid, respectively, and, in a subgroup of 120 participants, blood folate and plasma homocysteine.

Results

Pre- and post-intervention cognitive measurements were completed by 115 children in the intervention and 122 in the control group. Compared to control, median blood folate increased by about 50 % (P for difference, P < 0.0001). Homocysteine decreased by 1.1 μmol/L compared to baseline, no change was seen in the control group (P for difference P < 0.0001) and acetyl-para-aminobenzoylglutamate was 4 nmol/mmol higher compared to control at the end of the intervention (P < 0.0001). We found no relevant differences between the groups for the cognitive measures.

Conclusion

Short-term improvement of folate and homocysteine status in healthy children does not appear to affect cognitive performance.

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Titel: Three-month B vitamin supplementation in pre-school children affects folate status and homocysteine, but not cognitive performance
verfasst von: Astrid Rauh-Pfeiffer
Uschi Handel
Hans Demmelmair
Wolfgang Peissner
Mareile Niesser
Diego Moretti
Vanessa Martens
Sheila Wiseman
Judith Weichert
Moritz Heene
Markus Bühner
Berthold Koletzko
Publikationsdatum: 01.10.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 7/2014
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-013-0647-y

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Three-month B vitamin supplementation in pre-school children affects folate status and homocysteine, but not cognitive performance