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21.03.2020 | Note

Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities

verfasst von: Duc Viet Ho, Hanh Nhu Thi Hoang, Hung Quoc Vo, Khan Viet Nguyen, Ty Viet Pham, Anh Tuan Le, Kiem Van Phan, Hien Minh Nguyen, Hiroyuki Morita, Hoai Thi Nguyen

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2020

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Abstract

Three new steroidal saponins, aspiletreins A–C (1–3), together with 2H-chromen-2-one (4), and α-tocopherol (5), were isolated from whole Aspidistra letreae plants collected in Vietnam. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR, IR, and HRESIMS, and by comparison with the reported data in the literature. Compounds 1–3 exhibited moderate cytotoxicities against the LU-1, HeLa, MDA-MB-231, HepG2, and MKN-7 human cancer cell lines, with IC₅₀ values ranging from 7.69 ± 0.40 to 20.46 ± 3.11 µM.

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Titel: Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities
verfasst von: Duc Viet Ho
Hanh Nhu Thi Hoang
Hung Quoc Vo
Khan Viet Nguyen
Ty Viet Pham
Anh Tuan Le
Kiem Van Phan
Hien Minh Nguyen
Hiroyuki Morita
Hoai Thi Nguyen
Publikationsdatum: 21.03.2020
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2020
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-020-01395-9

Springer Medizin

Abstract

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