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01.07.2022 | Original Paper

TMCO1 expression promotes cell proliferation and induces epithelial–mesenchymal transformation in human gliomas

verfasst von: Lun Gao, Zhang Ye, Jun-Hui Liu, Ji-An Yang, Yong Li, Jia-Yang Cai, Yi-Xuan Wang, Shi-Ao Tong, Gang Deng, Shenqi Zhang, Qian-Xue Chen

Erschienen in: Medical Oncology | Ausgabe 7/2022

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Abstract

Transmembrane and coiled-coil domains 1 (TMCO1) is a recently discovered transmembrane protein of endoplasmic reticulum (ER), which plays a critical role in maintaining calcium homeostasis. TMCO1 dysfunction has been proved to be closely related to a variety of human diseases, including glaucoma, deformities, mental retardation and tumorigenesis. However, the role of TMCO1 in gliomas remains unclear. The purpose of this study was to detect the role of TMCO1 in the pathogenesis and progression of gliomas. This study demonstrated that TMCO1 was upregulated in gliomas and its overexpression predicted poor prognosis. We also revealed that the expression of TMCO1 was associated with the World Health Organization (WHO) grade of gliomas. Knockdown of TMCO1 inhibited the proliferation and induced apoptosis of U87 and U251 cells. In addition, TMCO1 induced GBM cell migration and invasion by promoting epithelial–mesenchymal transition (EMT). These date collectively proved the crucial role of TMCO1 as a novel prognostic factor and underlying therapeutic target for glioma patients.

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Titel: TMCO1 expression promotes cell proliferation and induces epithelial–mesenchymal transformation in human gliomas
verfasst von: Lun Gao
Zhang Ye
Jun-Hui Liu
Ji-An Yang
Yong Li
Jia-Yang Cai
Yi-Xuan Wang
Shi-Ao Tong
Gang Deng
Shenqi Zhang
Qian-Xue Chen
Publikationsdatum: 01.07.2022
Verlag: Springer US
Erschienen in: Medical Oncology / Ausgabe 7/2022
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-022-01687-y

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

TMCO1 expression promotes cell proliferation and induces epithelial–mesenchymal transformation in human gliomas

Abstract

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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