Background
Methods
Site of study and patients
Molecular characterization
Data analysis
Results
Clinical and demographic characteristics |
P. vivax malaria patients | Controls |
---|---|---|
n = 111 | N = 97 | |
Careiro | ||
Gender | ||
Male n (%) | 63 (57) | 61 (63) |
Female n (%) | 48 (43) | 36 (37) |
Age/years (mean ± SD) | 35.9 ± 17.8 | 34.2 ± 16 |
Previous history of malaria n (%) | 72 (65) | – |
Episodes of malaria (mean) | 05 | – |
Plasmodium vivax (%) | 81 | – |
Plasmodium falciparum (%) | 19 | – |
Clinical and demographic characteristics |
P. vivax malaria patients | Controls |
---|---|---|
n = 208 | n = 166 | |
Brasileirinho + Ipiranga + Puraquequara | ||
Gender | ||
Male n (%) | 131 (63) | 84 (51) |
Female n (%) | 77 (37) | 82 (49) |
Age/years (mean ± SD) | 39.5 ± 21.3 | 39.5 ± 21.3 |
Previous history of malaria n (%) | 174 (84) | – |
Episodes of malaria (mean) | 10 | – |
Plasmodium vivax (%) | 89 | – |
Plasmodium falciparum (%) | 11 | – |
Polymorphism, genotypes and, alleles |
P. vivax malaria patients | Controls |
---|---|---|
n = 301 (%) | n = 255 (%) | |
TOLLIP rs5743899 | ||
GG | 32 (11) | 24 (10) |
GA | 124 (41) | 108 (42) |
AA | 145 (48) | 123 (48) |
G | 188 (31) | 156 (31) |
A | 414 (69) | 354 (69) |
Polymorphism, genotypes and, alleles |
P. vivax malaria patients | Controls |
---|---|---|
n = 319 (%) | n = 263 (%) | |
TOLLIP rs3750920 | ||
CC | 66 (21) | 68 (26) |
CT | 134 (42) | 132 (50) |
TT | 119 (37) | 63 (24) |
C | 133 (42) | 134 (51) |
T | 186 (58) | 129 (49) |
Polymorphism, genotypes and, alleles |
P. vivax malaria patients | Controls |
---|---|---|
p value | OR [95% CI] | |
Genotypes and alleles comparisons TOLLIP rs3750920 | ||
CC vs. TT | 0.004 | 1.95 [1.23–3.07] |
CC + CT vs. TT | 0.0005 | 0.52 [0.37–0.76] |
TT vs. CT | 0.002 | 0.53 [0.36–0.79] |
T vs. C | 0.002 | 0.69 [0.55–0.87] |
Polymorphism and, genotypes |
P. vivax malaria patients | OR (IC 95%) | χ2
| (p) value | ||
---|---|---|---|---|---|---|
Low parasite load | High parasite load | |||||
n = 103 (%) | n = 102 (%) | |||||
TOLLIP 899 (rs3750920) | ||||||
G/G | 8 (8) | 11 (11) | 0.738 (0.423–1.287) | 1.15 | 0.283 | G/G + G/A vs. A/A |
G/A | 39 (38) | 28 (27) | 0.522 (0.186–1.466) | 1.55 | 0.213 | G/G vs. G/A |
A/A | 56 (54) | 63 (62) | 0.638 (0.349–1.168) | 2.13 | 0.144 | G/A vs. A/A |
TOLLIP rs3750920 | ||||||
C/C | 35 (34) | 37 (36) | 0.808 (0.434–1.506) | 0.45 | 0.501 | C/C vs. C/T |
C/T | 48 (47) | 41 (40) | 0.712 (0.345–1.470) | 0.85 | 0.357 | C/T vs. T/T |
T/T | 20 (19) | 24 (24) | 1.135 (0.535–2.408) | 0.11 | 0.741 | C/C vs. T/T |