Skip to main content
main-content

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Malaria Journal 1/2017

TOLLIP gene variant is associated with Plasmodium vivax malaria in the Brazilian Amazon

Zeitschrift:
Malaria Journal > Ausgabe 1/2017
Autoren:
Larissa W. Brasil, Laila R. A. Barbosa, Felipe J. de Araujo, Allyson G. da Costa, Luan D. O. da Silva, Suzana K. Pinheiro, Anne C. G. de Almeida, Andrea Kuhn, Sheila Vitor-Silva, Gisely C. de Melo, Wuelton M. Monteiro, Marcus V. G. de Lacerda, Rajendranath Ramasawmy

Abstract

Background

Toll-interacting protein is a negative regulator in the TLR signaling cascade, particularly by impeding the TLR2 and, TLR4 pathway. Recently, TOLLIP was shown to regulate human TLR signaling pathways. Two common TOLLIP polymorphisms (rs5743899 and rs3750920) were reported to be influencing IL-6, TNF and IL-10 expression. In this study, TOLLIP variants were investigated to their relation to Plasmodium vivax malaria in the Brazilian Amazon.

Methods

This cohort study was performed in the municipalities of Careiro and, Manaus, in Western Brazilian Amazon. A total of 319 patients with P. vivax malaria and, 263 healthy controls with no previous history of malaria were included in the study. Genomic DNA was extracted from blood collected on filter paper, using the QIAamp® DNA Mini Kit, according to the manufacturer’s suggested protocol. The rs5743899 and rs3750920 polymorphisms of the TOLLIP gene were typed by PCR–RFLP.

Results

Homozygous individuals for the rs3750920 T allele gene had twice the risk of developing malaria when compared to individuals homozygous for the C allele (OR 2.0 [95% CI 1.23–3.07]; p = 0.004). In the dominant model, carriers the C allele indicates protection to malaria, carriers of the C allele were compared to individuals with the T allele, and the difference is highly significant (OR 0.52 [95% CI 0.37–0.76]; p = 0.0006). The linkage disequilibrium between the two polymorphisms was weak (r2 = 0.037; D′ = 0.27).

Conclusions

These findings suggest that genes involved in the TLRs-pathway may be involved in malaria susceptibility. The association of the TOLLIP rs3750920 T allele with susceptibility to malaria further provides evidence that genetic variations in immune response genes may predispose individuals to malaria.
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2017

Malaria Journal 1/2017 Zur Ausgabe

Neu im Fachgebiet Innere Medizin

22.05.2019 | DAC 2019 | Kongressbericht | Nachrichten

So macht die Mischinfusion, was sie soll

22.05.2019 | DAC 2019 | Kongressbericht | Nachrichten

Neue Leitlinie "Prolongiertes Weaning" – ein Ausblick

22.05.2019 | DAC 2019 | Kongressbericht | Nachrichten

Juristische Fallstricke am Lebensende

Meistgelesene Bücher aus der Inneren Medizin

2017 | Buch

Rheumatologie aus der Praxis

Entzündliche Gelenkerkrankungen – mit Fallbeispielen

Dieses Fachbuch macht mit den wichtigsten chronisch entzündlichen Gelenk- und Wirbelsäulenerkrankungen vertraut. Anhand von über 40 instruktiven Fallbeispielen werden anschaulich diagnostisches Vorgehen, therapeutisches Ansprechen und der Verlauf …

Herausgeber:
Rudolf Puchner

2016 | Buch

Ambulant erworbene Pneumonie

Was, wann, warum – Dieses Buch bietet differenzierte Diagnostik und Therapie der ambulant erworbenen Pneumonie zur sofortigen sicheren Anwendung. Entsprechend der neuesten Studien und Leitlinien aller wichtigen Fachgesellschaften.

Herausgeber:
Santiago Ewig

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Innere Medizin und bleiben Sie gut informiert – ganz bequem per eMail.

© Springer Medizin 

Bildnachweise