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International Urology and Nephrology

Erschienen in:

01.12.2010 | Nephrology - Original Paper

Torque teno virus infection in hemodialysis patients in North India

verfasst von: Mohammad Irshad, Kishore Mandal, Shiwani Singh, S. K. Agarwal

Erschienen in: International Urology and Nephrology | Ausgabe 4/2010

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Abstract

This study describes the prevalence and association of Torque teno virus (TTV) infection with blood-transmitted viral hepatitis including hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in patients with chronic renal failure (CRF) on maintenance hemodialysis (HD). TTV infection was diagnosed by detection of TTV-DNA in serum, using the polymerase chain reaction (PCR) technique. TTV-DNA was estimated in a total number of one hundred patients with CRF and in 100 voluntary blood donors as controls. The markers of HBV and HCV were also tested in sera samples of these patients. TTV-DNA was detected in 39 of 100 patients (39%) with CRF and in 27 of 100 (27%) healthy controls. The analysis of the results demonstrated HBsAg, IgM anti-HBc, anti-HCV, and HCV core antigen in 5.0, 3.0, 6.0, and 4.0% of patients, respectively. This study could not show any association of TTV with HBV and HCV infections for the transmission pattern or any impact on severity of diseases caused by these viruses in CRF patients. TTV also could not show any association with demographic characteristics of patients, duration of dialysis, number of blood transfusions and renal/liver function of the patients. As such, this study concludes that TTV appears as a benign pathogen, showing no sign of renal/liver damage or any change in the severity of diseases caused by blood-borne hepatitis viruses.

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Titel: Torque teno virus infection in hemodialysis patients in North India
verfasst von: Mohammad Irshad
Kishore Mandal
Shiwani Singh
S. K. Agarwal
Publikationsdatum: 01.12.2010
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 4/2010
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-009-9648-4

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