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19.02.2022 | Original Article

Transcriptomic modulation in response to high-intensity interval training in monocytes of older women with type 2 diabetes

verfasst von: Jovane Hamelin Morrissette, Dominic Tremblay, Alexis Marcotte-Chénard, Farah Lizotte, Marie A. Brunet, Benoit Laurent, Eléonor Riesco, Pedro Geraldes

Erschienen in: European Journal of Applied Physiology | Ausgabe 4/2022

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Abstract

Purpose

Type 2 diabetes is associated with a higher risk of cardiovascular diseases, lowering the quality of life and increasing mortality rates of affected individuals. Circulating monocytes are tightly involved in the atherosclerosis process leading to cardiovascular diseases (CVD), and their inflammatory profile can be modified by exercise. The objective was to exploratory identify genes associated with CVD that could be regulated by high-intensity interval training (HIIT) in monocytes of type 2 diabetes patients.

Methods

Next-generation RNA sequencing (RNA-seq) analyses were conducted on isolated circulating monocytes (CD14⁺) of six women aged 60 and over with type 2 diabetes who completed a 12-week supervised HIIT intervention on a treadmill.

Results

Following the intervention, a reduction of resting diastolic blood pressure was observed. Concomitant with this result, 56 genes were found to be downregulated following HIIT intervention in isolated monocytes. A large proportion of the regulated genes was involved in cellular adhesion, migration and differentiation into an “atherosclerosis-specific” macrophage phenotype.

Conclusion

The downregulation of transcripts in monocytes globally suggests a favorable cardiovascular effect of the HIIT in older women with type 2 diabetes. In the context of precision medicine and personalized exercise prescription, shedding light on the fundamental mechanisms underlying HIIT effects on the gene profile of immune cells is essential to develop efficient nonpharmacological strategies to prevent CVD in high-risk population.

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Titel: Transcriptomic modulation in response to high-intensity interval training in monocytes of older women with type 2 diabetes
verfasst von: Jovane Hamelin Morrissette
Dominic Tremblay
Alexis Marcotte-Chénard
Farah Lizotte
Marie A. Brunet
Benoit Laurent
Eléonor Riesco
Pedro Geraldes
Publikationsdatum: 19.02.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 4/2022
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-022-04911-9

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Springer Medizin

Transcriptomic modulation in response to high-intensity interval training in monocytes of older women with type 2 diabetes

Abstract

Purpose

Methods

Results

Conclusion

Neu im Fachgebiet Arbeitsmedizin

Das Geschlechterparadoxon in der gesundheitlich beeinträchtigten Lebenszeit – Ende eines Mythos?

Gesunde Lebenserwartung: Ein kritischer Blick auf Nutzen und Potenziale des demographischen Gesundheitsindikators

Wie hat sich die Lebenserwartung ohne funktionelle Einschränkungen in Deutschland entwickelt? Eine Analyse mit Daten des Deutschen Alterssurveys (DEAS)

Hitzeschutz im Fokus der hessischen Betreuungs- und Pflegeaufsicht

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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