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Journal of Natural Medicines

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01.01.2017 | Review

Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives

verfasst von: Megan M. Marlow, Sumedh S. Shah, Eduardo A. Véliz, Michael E. Ivan, Regina M. Graham

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2017

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Abstract

Resistance mechanisms employed by high-grade gliomas allow them to successfully evade current standard treatment of chemotherapy and radiation treatment. Withaferin A (WA), utilized in Ayurvedic medicine for centuries, is attracting attention for its antitumor capabilities. Here we review pertinent literature on WA as a high-grade glioma treatment, and discuss the cancerous mechanisms it affects. WA is relatively nontoxic and has shown potential in crossing the blood–brain barrier. WA prevents p53 alterations and inactivates overexpressed MDM2 through ARF and ROS production. Furthermore, WA upregulates Bax, inducing mitochondrial death cascades, inhibits mutated Akt, mTOR, and NF-κB pathways, and inhibits angiogenesis in tumors. Therapy with WA for high-grade gliomas is supported through the literature. Further investigation is warranted and encouraged to fully unearth its abilities against malignant gliomas.

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Titel: Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives
verfasst von: Megan M. Marlow
Sumedh S. Shah
Eduardo A. Véliz
Michael E. Ivan
Regina M. Graham
Publikationsdatum: 01.01.2017
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2017
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-016-1020-2

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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