nach oben

Spektrum der Augenheilkunde

Erschienen in:

13.07.2021 | Trockenes Auge | review

Diagnostik des Trockenen Auges

verfasst von: PD Dr. Stefan Palkovits, PhD

Erschienen in: Spektrum der Augenheilkunde | Ausgabe 5/2021

Einloggen, um Zugang zu erhalten

Zusammenfassung

Die Diagnostik des Trockenen Auges umfasst ein breites Feld an unterschiedlichen Untersuchungsmodalitäten, wie beispielsweise die Beurteilung des Tränenfilms, der Augenoberfläche und der Augenlider. Das folgende Review beinhaltet eine strukturierte Übersicht der genannten Untersuchungen sowie Empfehlungen zur Durchführung dieser. Eine möglichst exakte Diagnose ist eine Grundvoraussetzung, um eine entsprechende Therapie einzuleiten und die Beschwerden der PatientInnen zu behandeln.

Nichols KK, Nichols JJ, Mitchell GL. The lack of association between signs and symptoms in patients with dry eye disease. Cornea. 2004; https://doi.org/10.1097/01.ico.0000133997.07144.9e.CrossRefPubMed

Sullivan BD, Crews LA, Messmer EM, et al. Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: clinical implications. Acta Ophthalmol. 2014; https://doi.org/10.1111/aos.12012.CrossRefPubMed

Begley CG, Chalmers RL, Abetz L, et al. The relationship between habitual patient-reported symptoms and clinical signs among patients with dry eye of varying severity. Invest Ophthalmol Vis Sci. 2003; https://doi.org/10.1167/iovs.03-0270.CrossRefPubMed

Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS II definition and classification report. Ocul Surf. 2017; https://doi.org/10.1016/j.jtos.2017.05.008.CrossRefPubMed

Wolffsohn JS, Arita R, Chalmers R, et al. TFOS DEWS II diagnostic methodology report. Ocul Surf. 2017; https://doi.org/10.1016/j.jtos.2017.05.001.CrossRefPubMedPubMedCentral

Foulks GN. Challenges and pitfalls in clinical trials of treatments for dry eye. Ocul Surf. 2003; https://doi.org/10.1016/S1542-0124(12)70004-6.CrossRefPubMed

Begley CG, Chalmers RL, Mitchell GL, et al. Characterization of ocular surface symptoms from optometric practices in North America. Cornea. 2001; https://doi.org/10.1097/00003226-200108000-00011.CrossRefPubMed

Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. Reliability and validity of the ocular surface disease index. Arch Ophthalmol. 2000; https://doi.org/10.1001/archopht.118.5.615.CrossRefPubMed

Finis D, Pischel N, König C, et al. Comparison of the OSDI and SPEED questionnaires for the evaluation of dry eye disease in clinical routine. Ophthalmologe. 2014; https://doi.org/10.1007/s00347-014-3042-z.CrossRefPubMed

10.

Solomon JD, Greiner JV, Korb DR. Correlation and comparison of two dry eye questionnaires: standard patient evaluation of eye dryness (SPEED) vs. ocular surface disease index (OSDI). Invest Ophthalmol Vis Sci. 2008;49:5324.

11.

Blackie CA, Solomon JD, Scaffidi RC, Greiner JV, Lemp MA, Korb DR. The relationship between dry eye symptoms and lipid layer thickness. Cornea. 2009; https://doi.org/10.1097/ico.0b013e318191b870.CrossRefPubMed

12.

Schaumberg DA, Gulati A, Mathers WD, et al. Development and validation of a short global dry eye symptom index. Ocul Surf. 2007; https://doi.org/10.1016/S1542-0124(12)70053-8.CrossRefPubMed

13.

Cher I. A new look at lubrication of the ocular surface: fluid mechanics behind the blinking eyelids. Ocul Surf. 2008; https://doi.org/10.1016/S1542-0124(12)70271-9.CrossRefPubMed

14.

Willcox MDP, Argüeso P, Georgiev GA, et al. TFOS DEWS II tear film report. Ocul Surf. 2017; https://doi.org/10.1016/j.jtos.2017.03.006.CrossRefPubMedPubMedCentral

15.

Mooi JK, Wang MTM, Lim J, Müller A, Craig JP. Minimising instilled volume reduces the impact of fluorescein on clinical measurements of tear film stability. Contact Lens Anterior Eye. 2017; https://doi.org/10.1016/j.clae.2017.01.004.CrossRefPubMed

16.

Wang MTM, Murphy PJ, Blades KJ, Craig JP. Comparison of non-invasive tear film stability measurement techniques. Clin Exp Optom. 2018; https://doi.org/10.1111/cxo.12546.CrossRefPubMed

17.

Downie LE. Automated tear film surface quality breakup time as a novel clinical marker for tear hyperosmolarity in dry eye disease. Invest Ophthalmol Vis Sci. 2015; https://doi.org/10.1167/iovs.15-17772.CrossRefPubMed

18.

Nichols KK, Mitchell GL, Zadnik K. The repeatability of clinical measurements of dry eye. Cornea. 2004; https://doi.org/10.1097/00003226-200404000-00010.CrossRefPubMed

19.

Yokoi N, Bron AJ, Tiffany JM, Kinoshita S. Reflective meniscometry: a new field of dry eye assessment. Cornea. 2000; https://doi.org/10.1097/00003226-200005001-00008.CrossRefPubMed

20.

Mishima S, Gasset A, Klyce SD, Baum JL. Determination of tear volume and tear flow. Invest Ophthalmol. 1966;5(3):264–76.PubMed

21.

Werkmeister RM, Alex A, Kaya S, et al. Measurement of tear film thickness using ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2013; https://doi.org/10.1167/iovs.13-11920.CrossRefPubMed

22.

Schmidl D, Witkowska KJ, Kaya S, et al. The association between subjective and objective parameters for the assessment of dry-eye syndrome. Invest Ophthalmol Vis Sci. 2015; https://doi.org/10.1167/iovs.14-15814.CrossRefPubMed

23.

Garhöfer G, Dos Santos VA, Stegmann H, et al. The association between tear film thickness as measured with OCT and symptoms and signs of dry eye disease: a pooled analysis of 6 clinical trials. J Clin Med. 2020; https://doi.org/10.3390/jcm9113791.CrossRefPubMedPubMedCentral

24.

Ang M, Baskaran M, Werkmeister RM, et al. Anterior segment optical coherence tomography. Prog Retin Eye Res. 2018; https://doi.org/10.1016/j.preteyeres.2018.04.002.CrossRefPubMed

25.

Nguyen P, Huang D, Li Y, et al. Correlation between optical coherence tomography-derived assessments of lower tear meniscus parameters and clinical features of dry eye disease. Cornea. 2012; https://doi.org/10.1097/ICO.0b013e3182261577.CrossRefPubMedPubMedCentral

26.

Li L, Braun RJ, Driscoll TA, Henshaw WD, Banks JW, King-Smith PE. Computed tear film and osmolarity dynamics on an eye-shaped domain. Math Med Biol. 2016; https://doi.org/10.1093/imammb/dqv013.CrossRefPubMed

27.

Braun RJ, King-Smith PE, Begley CG, Li L, Gewecke NR. Dynamics and function of the tear film in relation to the blink cycle. Prog Retin Eye Res. 2015; https://doi.org/10.1016/j.preteyeres.2014.11.001.CrossRefPubMed

28.

Potvin R, Makari S, Rapuano CJ. Tear film osmolarity and dry eye disease: a review of the literature. Clin Ophthalmol. 2015; https://doi.org/10.2147/OPTH.S95242.CrossRefPubMedPubMedCentral

29.

Jackson DC, Zeng W, Wong CY, et al. Tear interferon-gamma as a biomarker for evaporative dry eye disease. Invest Ophthalmol Vis Sci. 2016; https://doi.org/10.1167/iovs.16-19757.CrossRefPubMedPubMedCentral

30.

Tomlinson A, Khanal S, Ramaesh K, Diaper C, McFadyen A. Tear film osmolarity: determination of a referent for dry eye diagnosis. Invest Ophthalmol Vis Sci. 2006; https://doi.org/10.1167/iovs.05-1504.CrossRefPubMed

31.

Bron AJ, Tomlinson A, Foulks GN, et al. Rethinking dry eye disease: a perspective on clinical implications. Ocul Surf. 2014; https://doi.org/10.1016/j.jtos.2014.02.002.CrossRefPubMed

32.

Rolando M, Baldi F, Zingirian M. The effect of hyperosmolarity on tear mucus ferning. Fortschr Ophthalmol. 1986;83(6):644–6.PubMed

33.

Maragou M, Vaikousis E, Ntre A, et al. Tear and saliva ferning tests in sjögren’s syndrome (SS). Clin Rheumatol. 1996; https://doi.org/10.1007/BF02230328.CrossRefPubMed

34.

Horwath J, Ettinger K, Bachernegg M, Bodner E, Schmut O. Ocular ferning test—effect of temperature and humidity on tear ferning patterns. Ophthalmologica. 2001; https://doi.org/10.1159/000050838.CrossRefPubMed

35.

Bron AJ, Argüeso P, Irkec M, Bright FV. Clinical staining of the ocular surface: mechanisms and interpretations. Prog Retin Eye Res. 2015; https://doi.org/10.1016/j.preteyeres.2014.10.001.CrossRefPubMed

36.

Argüeso P, Tisdale A, Spurr-Michaud S, Sumiyoshi M, Gipson IK. Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye. Invest Ophthalmol Vis Sci. 2006; https://doi.org/10.1167/iovs.05-0735.CrossRefPubMed

37.

Dundas M, Walker A, Woods RL. Clinical grading of corneal staining of non-contact lens wearers. Ophthalmic Physiol Opt. 2001; https://doi.org/10.1016/S0275-5408(00)00011-9.CrossRefPubMed

38.

Bron AJ, de Paiva CS, Chauhan SK, et al. TFOS DEWS II pathophysiology report. Ocul Surf. 2017; https://doi.org/10.1016/j.jtos.2017.05.011.CrossRefPubMed

39.

Whitcher JP, Shiboski CH, Shiboski SC, et al. A simplified quantitative method for assessing Keratoconjunctivitis sicca from the Sjögren’s syndrome international registry. Am J Ophthalmol. 2010; https://doi.org/10.1016/j.ajo.2009.09.013.CrossRefPubMed

40.

Höh H. Lidkantenparallele Konjunktivale Falten. Trockenes Auge: Anatomie, Physiologie, Pathophysiologie, Diagnostik Und Therapie Des Sicca-Syndroms. : Kaden Verlag; 2001.

41.

Calonge M, Diebold Y, Sáez V, et al. Impression cytology of the ocular surface: a review. Exp Eye Res. 2004; https://doi.org/10.1016/j.exer.2003.09.009.CrossRefPubMed

42.

Haller-Schober EM, Schwantzer G, Berghold A, Fischl M, Theisl A, Horwath-Winter J. Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome. Eye (Lond). 2006; https://doi.org/10.1038/sj.eye.6702058.CrossRef

43.

Messmer EM, von Lindenfels V, Garbe A, Kampik A. Matrix metalloproteinase 9 testing in dry eye disease using a commercially available point-of-care Immunoassay. Ophthalmology. 2016; https://doi.org/10.1016/j.ophtha.2016.07.028.CrossRefPubMed

44.

Kaufman HE. The practical detection of MMP‑9 diagnoses ocular surface disease and may help prevent its complications. Cornea. 2013; https://doi.org/10.1097/ICO.0b013e3182541e9a.CrossRefPubMed

45.

Chan TCY, Chow SSW, Wan KHN, Yuen HKL. Update on the association between dry eye disease and meibomian gland dysfunction. Hong Kong Med J. 2019; https://doi.org/10.12809/hkmj187331.CrossRefPubMed

46.

Geerling G, Tauber J, Baudouin C, et al. The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2011; https://doi.org/10.1167/iovs.10-6997g.CrossRefPubMedPubMedCentral

47.

Goto E, Tseng SCG. Differentiation of lipid tear deficiency dry eye by kinetic analysis of tear interference images. Arch Ophthalmol. 2003; https://doi.org/10.1001/archopht.121.2.173.CrossRefPubMed

48.

Li J, Ma J, Hu M, Yu J, Zhao Y. Assessment of tear film lipid layer thickness in patients with Meibomian gland dysfunction at different ages. BMC Ophthalmol. 2020; https://doi.org/10.1186/s12886-020-01667-8.CrossRefPubMedPubMedCentral

49.

Eom Y, Lee JS, Kang SY, Kim HM, Song JS. Correlation between quantitative measurements of tear film lipid layer thickness and meibomian gland loss in patients with obstructive meibomian gland dysfunction and normal controls. Am J Ophthalmol. 2013; https://doi.org/10.1016/j.ajo.2013.01.008.CrossRefPubMed

50.

Hwang JH, Lee JH, Chung SH. Comparison of Meibomian gland imaging findings and lipid layer thickness between primary Sjögren syndrome and non-Sjögren syndrome dry eyes. Ocul Immunol Inflamm. 2020; https://doi.org/10.1080/09273948.2018.1562557.CrossRefPubMed

51.

Yamaguchi M, Kutsuna M, Uno T, Zheng X, Kodama T, Ohashi Y. Marx line: fluorescein staining line on the inner lid as indicator of meibomian gland function. Am J Ophthalmol. 2006; https://doi.org/10.1016/j.ajo.2005.11.004.CrossRefPubMed

52.

Jansen ME, Begley CG, Himebaugh NH, Port NL. Effect of contact lens wear and a near task on tear film break-up. Optom Vis Sci. 2010; https://doi.org/10.1097/OPX.0b013e3181d951df.CrossRefPubMed

Titel: Diagnostik des Trockenen Auges
verfasst von: PD Dr. Stefan Palkovits, PhD
Publikationsdatum: 13.07.2021
Verlag: Springer Vienna
Schlagwort: Trockenes Auge
Erschienen in: Spektrum der Augenheilkunde / Ausgabe 5/2021
Print ISSN: 0930-4282
Elektronische ISSN: 1613-7523
DOI: https://doi.org/10.1007/s00717-021-00495-5

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Diagnostik des Trockenen Auges

Zusammenfassung

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde

Springer Medizin

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2021

Allergie und Trockenes Auge

Attrition und Osmokinetik – Zwei Konzepte zur Pathogenese des Trockenen Auges

Das postoperative trockene Auge nach ophthalmochirurgischen Eingriffen

Trockenes Auge – Update

Anwendungsmöglichkeiten der optischen Kohärenztomographie beim trockenen Auge

Therapie des Trockenen Auges

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde