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Acta Neurochirurgica

Erschienen in:

04.02.2020 | Original Article - Tumor - Schwannoma

Tumor miRNA expression profile is related to vestibular schwannoma growth rate

verfasst von: Hjalte C. R. Sass, Morten Hansen, Rehannah Borup, Finn Cilius Nielsen, Per Cayé-Thomasen

Erschienen in: Acta Neurochirurgica | Ausgabe 5/2020

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Abstract

Objective

Our objective was to investigate if the tumor microRNA (miRNA) expression profile was related to tumor growth rate. Growth-related miRNAs might be potential targets for future therapeutic intervention.

Material and methods

Tumor tissue was sampled during surgery of patients with a sporadic vestibular schwannoma. Tumor growth rate was determined by tumor measurement on the two latest pre-operative MRI scans. Tumor miRNA expression was analyzed using the Affymetrix Gene Chip® protocol, and CEL files were generated using GeneChip® Command Console® Software and normalized using Partek Genomics Suite 6.5. The CEL files were analyzed using the statistical software program R. Principal component analysis, affected gene ontology analysis, and analysis of miRNA expression fold changes were used for analysis of potential relations between miRNA expression profile and tumor growth rate.

Results and conclusion

Tumor miRNA expression is related to the growth rate of sporadic vestibular schwannomas. Rapid tumor growth is associated with deregulation of several miRNAs, including upregulation of miR-29abc, miR-19, miR-340-5p, miR-21, and miR-221 and downregulation of miR-744 and let-7b. Gene ontologies affected by the deregulated miRNAs included neuron development and differentiation, gene silencing, and negative regulation of various biological processes, including cellular and intracellular signaling and metabolism.

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Titel: Tumor miRNA expression profile is related to vestibular schwannoma growth rate
verfasst von: Hjalte C. R. Sass
Morten Hansen
Rehannah Borup
Finn Cilius Nielsen
Per Cayé-Thomasen
Publikationsdatum: 04.02.2020
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 5/2020
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-020-04238-4

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Material and methods

Results and conclusion

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