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Erschienen in:
01.01.2015 | Original Article
Twelve-month treatment with Liraglutide ameliorates Visceral Adiposity Index and common cardiovascular risk factors in type 2 diabetes outpatients
Erschienen in: Journal of Endocrinological Investigation | Ausgabe 1/2015
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Aim
In addition to the effects on glycemic control and body weight, GLP-1 receptor agonists may favorably affect other major cardiovascular disease (CVD) risk factors, although currently available data are still sparse. In this retrospective study, we evaluated the effects of 12-month treatment with liraglutide on major CVD risk factors in 115 type 2 diabetes outpatients (60 men and 55 women), on stable hypoglycemic, anti-hypertensive and/or lipid-lowering therapy.
Methods
Clinical and anthropometric data, metabolic and lipid profile, as well as the Visceral Adiposity Index (VAI), an obesity-related CVD risk factor, were measured in all participants at baseline and after 12-month treatment.
Results
Treatment with liraglutide was associated with a significant reduction from baseline values of fasting blood glucose (−42.1 mg/dl, P < 0.05), HbA1c (−1.5 %, −17 mmol/mol, P < 0.05), body weight (−7.1 kg, P < 0.05), waist circumference (-6.8 cm, P < 0.001), total-cholesterol (−27.4 mg/dl, P < 0.05), LDL-cholesterol (−25.4 mg/dl, P < 0.05), triglycerides (−56.1 mg/dl, P < 0.05), and non-HDL-C (−36.6 mg/dl, P < 0.05) and an increase of HDL-cholesterol concentrations (+9.3 mg/dl, P < 0.001), a significant reduction in both systolic and diastolic blood pressure (−14.7 mmHg, P < 0.001 and −9.0 mmHg, P < 0.05, respectively) and a decrease of VAI values (−1.6, P < 0.001). All these differences were independent of changes in BMI and comparable in men and women.
Conclusions
In conclusion, 12-month treatment with liraglutide in add-on to on-going hypoglycemic therapy significantly ameliorates all major CVD risk factors and reduces cardiometabolic risk, as estimated by VAI values.