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02.03.2022 | Original Article

Ultrasonographic evaluation reveals thinning of cervical nerve roots and peripheral nerves in spinal and bulbar muscular atrophy

verfasst von: Daisuke Watanabe, Hiroshi Tsukamoto, Tatsuya Abe, Ruriko Kitao, Aya Okuma, Masatoshi Mihara, Atsuko Katsumoto, Yukiko Iwahashi, Yuichi Higashiyama, Yosuke Miyaji, Hideto Joki, Hiroshi Doi, Tetsuo Komori, Fumiaki Tanaka

Erschienen in: Neurological Sciences | Ausgabe 7/2022

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Abstract

Background

Ultrasonography (US) is a noninvasive and patient-friendly tool for the evaluation of peripheral nerves. In motor neuron diseases, amyotrophic lateral sclerosis (ALS) has been reported to show the atrophy of peripheral nerves on US. However, the US findings are still unclear in spinal and bulbar muscular atrophy (SBMA), an adult-onset lower motor neuron disease caused by an abnormal CAG repeat expansion in the androgen receptor gene.

Methods

We prospectively recruited and evaluated 11 patients with genetically confirmed SBMA and 9 patients with ALS diagnosed according to the revised El Escorial ALS criteria or the Awaji electrodiagnostic criteria. The C5–C7 cervical nerve roots and the median and ulnar nerves were evaluated ultrasonographically.

Results

The cross-sectional areas (CSAs) of the C6 and C7 nerve roots, the median nerve in the upper arm and forearm, and the ulnar nerve in the upper arm were smaller in patients with SBMA than those in patients with ALS (p < 0.05), whereas the CSAs of the C5 nerve root and the ulnar nerve in the forearm were not smaller.

Conclusions

US showed that the peripheral nerves in patients with SBMA were thinner than those in patients with ALS despite similar degrees of weakness and motor neuron loss. Possible causes include additional sensory nerve involvement and longer disease duration in patients with SBMA than those in patients with ALS.

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Titel: Ultrasonographic evaluation reveals thinning of cervical nerve roots and peripheral nerves in spinal and bulbar muscular atrophy
verfasst von: Daisuke Watanabe
Hiroshi Tsukamoto
Tatsuya Abe
Ruriko Kitao
Aya Okuma
Masatoshi Mihara
Atsuko Katsumoto
Yukiko Iwahashi
Yuichi Higashiyama
Yosuke Miyaji
Hideto Joki
Hiroshi Doi
Tetsuo Komori
Fumiaki Tanaka
Publikationsdatum: 02.03.2022
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 7/2022
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-05969-1

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Abstract

Background

Methods

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Conclusions

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