Erschienen in:
01.05.2008 | Poster presentation
Understanding and exploiting changes in O-linked glycosylation in breast cancer
verfasst von:
S Julien, J Coleman, G Picco, R Beatson, J Taylor-Papadimitriou, J Burchell
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2008
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Excerpt
The differences in glycosylation patterns seen in breast malignancy strongly influence the final structure of membrane and secreted glycoproteins, and these novel tumour-associated glycoforms can modify the behaviour of the malignant cell and its interaction with immune effector cells. Changes in mucin type O-glycosylation occur in breast carcinomas and are the result, at least in part, of changes in the expression of specific glycosyltransferases [
1]. A similar change in the expression of glycosyltransferases resulting in the change of glycans attached to O-linked glycoproteins is seen when normal dendritic cells mature and migrate to the lymph nodes [
2]. As 70% to 80% of metastatic breast cancers metastasize via the lymphatics, a particular pattern of O-linked glycans may be required for cells to migrate and/or settle in the lymph nodes. …
