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Current HIV/AIDS Reports
Erschienen in: Current HIV/AIDS Reports 2/2014

01.06.2014 | The Global Epidemic (S Vermund, Section Editor)

Understanding HIV Compartments and Reservoirs

verfasst von: Valentina Svicher, Francesca Ceccherini-Silberstein, Andrea Antinori, Stefano Aquaro, Carlo Federico Perno

Erschienen in: Current HIV/AIDS Reports | Ausgabe 2/2014

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Abstract

The spectrum of HIV-1 cellular reservoirs is highly diversified, and their role varies according to the milieu of the anatomical sites in which the virus replicates. In this light, mechanisms underlying HIV-1 persistence in anatomical compartments may be profoundly different from what is observed in peripheral blood. This scenario is further complicated by sub-optimal drug penetration in tissues allowing persistent and cryptic HIV-1 replication in body districts despite undetectable viremia. On this basis, this review aims at providing recent insights regarding the critical role of HIV-1 cellular reservoirs in different anatomical compartments, and their relationship with the pathogenesis of HIV-1 infection. A comprehensive definition of the complex interplay between the virus and its reservoir is critical in order to set up prophylactic and therapeutic strategies aimed at achieving the maximal virological suppression and hopefully in the near future the cure of HIV-1 infection (either functional or biological).
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Metadaten
Titel
Understanding HIV Compartments and Reservoirs
verfasst von
Valentina Svicher
Francesca Ceccherini-Silberstein
Andrea Antinori
Stefano Aquaro
Carlo Federico Perno
Publikationsdatum
01.06.2014
Verlag
Springer US
Erschienen in
Current HIV/AIDS Reports / Ausgabe 2/2014
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-014-0207-y

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