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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Undifferentiated-type gastric adenocarcinoma: prognostic impact of three histological types

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Han Hong Lee, Kyo Young Song, Cho Hyun Park, Hae Myung Jeon
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-254) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

HHLcontributed to study conception and design, analysis of data, drafting of the manuscript and critical revision. KYS was responsible for acquisition and interpretation of data. CHP was responsible for interpretation of data and critical revision. HMJ contributed to study conception and design and critical revision. All authors read and approved the final manuscript.

Abstract

Background

The prognostic value of the three constituents of undifferentiated-type gastric adenocarcinoma remains unclear. The present study assessed the clinicopathological characteristics and prognosis of undifferentiated-type mucinous adenocarcinoma (uMAC) and signet ring cell carcinoma (SRC) compared with those of poorly differentiated adenocarcinoma (PDAC).

Methods

In total, 1,376 patients with undifferentiated-type gastric adenocarcinoma were included, consisting of 1,002 patients diagnosed with PDAC, 54 with uMAC and 320 with SRC. Clinicopathological factors and survival rates were compared among the three histological types.

Results

Significant differences in the distribution of pathological stages were observed among the groups. Patients with SRC had a significantly better survival rate than those with PDAC or uMAC, in both the all patients including non-curative resected patients and curative-resected groups. In addition, there was significant difference in survival between the PDAC and uMAC groups. Multivariate analysis suggested that age, gender, tumor depth, lymph node metastasis and curability significantly affected survival. Histological type was not an independent prognostic factor. There was no significant difference in the pattern of recurrence among the three groups.

Conclusions

The uMAC and SRC had worse and favorable prognosis compared with PDCA, respectively. However, there were no differences in survival by pathological stage, thus histological type was not an independent predictor of prognosis.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_1179_MOESM1_ESM.tiff
Authors’ original file for figure 2
12957_2012_1179_MOESM2_ESM.tiff
Literatur
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