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Erschienen in: Neuroradiology 3/2012

01.03.2012 | Interventional Neuroradiology

Unprotected carotid artery stenting: complications in 6 months follow-up

verfasst von: Reza Mohammadian, Bahram Sohrabi, Reza Mansourizadeh, Farideh Mohammadian, Babak Nasiri, Sajad Haririan

Erschienen in: Neuroradiology | Ausgabe 3/2012

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Abstract

Introduction

The most serious complications of carotid artery stenting (CAS) are related to the release of particles into the cerebral circulation. Although embolic protection devices may reduce the incidence of cerebral embolization, their use may be associated with additional complications including spasm or dissection. In this report, we present our experience with patients who underwent unprotected CAS.

Methods

We prospectively enrolled patients with symptomatic internal carotid artery stenosis from October 2008 to June 2010.Stenosis diagnosed based on carotid duplex and/or CT angiography findings and confirmed by digital subtraction angiography. All stenting procedures were done without using a protection device. Neurologist evaluated neurological situation of the patients, 24 h, 30 days, 3 and 6 months after stenting. Patients had carotid duplex scan scheduled on the third and sixth month after the procedure.

Results

Overall, 116patients underwent stenting; technical success rate was 100% .Mean age of patients was 68.48 ± 9.84 years, and 69% of the patients were male. One patient (1/116, 0.86%) developed transient ischemic attack during the procedure. One non-neurologic death (1/116, 0.86%) occurred 18 h after the procedure because of myocardial infarction. In 1-month follow-up, only one patient (1/115, 0.87%) presented with neurological complication as a consequence of thalamic hemorrhagic. Six months follow-up revealed two cases (2/115, 1.74%) with in-stent restenosis which one of them was severe and symptomatic and underwent angioplasty.

Conclusion

Unprotected carotid stenting appears to accompany with low early and late complications. Cerebral embolization during CAS is not the only cause of these complications and the use of cerebral protection devices may therefore not prevent all major complications including myocardial infarction, hyperperfusion syndrome, and re-stenosis.
Literatur
1.
Zurück zum Zitat Goodney PP, Schemerhone ML, Powell RJ (2006) Current status of carotid artery stenting. J Vasc Surg 43:406–411PubMedCrossRef Goodney PP, Schemerhone ML, Powell RJ (2006) Current status of carotid artery stenting. J Vasc Surg 43:406–411PubMedCrossRef
2.
Zurück zum Zitat van Heesewijk HP, Vos JA, Louwerse ES, van den Berg JC, Overtoom TT, Ernst SM, Mauser HW, Moll FL, Ackerstaff RG, Carotid PTA and Stenting Collaborative Research Group (2002) New brain lesions at MR imaging after carotid angioplasty and stent placement. Radiology 224:361–365PubMedCrossRef van Heesewijk HP, Vos JA, Louwerse ES, van den Berg JC, Overtoom TT, Ernst SM, Mauser HW, Moll FL, Ackerstaff RG, Carotid PTA and Stenting Collaborative Research Group (2002) New brain lesions at MR imaging after carotid angioplasty and stent placement. Radiology 224:361–365PubMedCrossRef
3.
Zurück zum Zitat Reimers B, Corvaja N, Moshiri S, Sacca S, Albiero R, Di Mario C, Pascotto P, Colombo A (2001) Cerebral protection with filter devices during carotid artery stenting. Circulation 104:12–15PubMedCrossRef Reimers B, Corvaja N, Moshiri S, Sacca S, Albiero R, Di Mario C, Pascotto P, Colombo A (2001) Cerebral protection with filter devices during carotid artery stenting. Circulation 104:12–15PubMedCrossRef
4.
Zurück zum Zitat Al-Mubarak N, Roubin GS, Vitek JJ, Iyer SS, New G, Leon MB (2001) Effect of the distal-balloon protection system on microembolization during carotid stenting. Circulation 104:1999–2002PubMedCrossRef Al-Mubarak N, Roubin GS, Vitek JJ, Iyer SS, New G, Leon MB (2001) Effect of the distal-balloon protection system on microembolization during carotid stenting. Circulation 104:1999–2002PubMedCrossRef
5.
Zurück zum Zitat Kastrup A, Groschel K, Krapf H, Brehm BR, Dichgans J, Schulz JB (2003) Early outcome of carotid angioplasty and stenting with and without cerebral protection devices: a systematic review of the literature. Stroke 34:813–819PubMedCrossRef Kastrup A, Groschel K, Krapf H, Brehm BR, Dichgans J, Schulz JB (2003) Early outcome of carotid angioplasty and stenting with and without cerebral protection devices: a systematic review of the literature. Stroke 34:813–819PubMedCrossRef
6.
Zurück zum Zitat Cremonesi A, Manetti R, Setacci F, Setacci C, Castriota F (2003) Protected carotid stenting: clinical advantages and complications of embolic protection devices in 442 consecutive patients. Stroke 34:1936–1941PubMedCrossRef Cremonesi A, Manetti R, Setacci F, Setacci C, Castriota F (2003) Protected carotid stenting: clinical advantages and complications of embolic protection devices in 442 consecutive patients. Stroke 34:1936–1941PubMedCrossRef
7.
Zurück zum Zitat Eckert B, Zeumer H (2003) Editorial comment—carotid artery stenting with or without protection devices? Strong opinions, poor evidence. Stroke 34:1941–1943PubMedCrossRef Eckert B, Zeumer H (2003) Editorial comment—carotid artery stenting with or without protection devices? Strong opinions, poor evidence. Stroke 34:1941–1943PubMedCrossRef
8.
Zurück zum Zitat Perona F, Castellazzi G, Valvassori L, Boccardi E, de Girolamo L, Cornalba GP et al (2009) Safety of unprotected carotid artery stent placement in symptomatic and asymptomatic patients: a retrospective analysis of 30-day combined adverse outcomes. Radiology 250(1):178–183PubMedCrossRef Perona F, Castellazzi G, Valvassori L, Boccardi E, de Girolamo L, Cornalba GP et al (2009) Safety of unprotected carotid artery stent placement in symptomatic and asymptomatic patients: a retrospective analysis of 30-day combined adverse outcomes. Radiology 250(1):178–183PubMedCrossRef
9.
Zurück zum Zitat Tietke MWK, Kerby T, Alfke K, Riedel C, Rohr A, Jensen U et al (2010) Complication rate in unprotected carotid artery stenting with closed-cell stents. Neuroradiology 52:611–618PubMedCrossRef Tietke MWK, Kerby T, Alfke K, Riedel C, Rohr A, Jensen U et al (2010) Complication rate in unprotected carotid artery stenting with closed-cell stents. Neuroradiology 52:611–618PubMedCrossRef
10.
Zurück zum Zitat Barbato JE, Dillavou E, Horowitz MB, Jovin TG, Kanal E, David S et al (2008) A randomized trial of carotid artery stenting with and without cerebral protection. J Vasc Surg 47:760–765PubMedCrossRef Barbato JE, Dillavou E, Horowitz MB, Jovin TG, Kanal E, David S et al (2008) A randomized trial of carotid artery stenting with and without cerebral protection. J Vasc Surg 47:760–765PubMedCrossRef
11.
Zurück zum Zitat Theiss W, Hermanek P, Mathias K et al (2008) Predictors of death and stroke after carotid angioplasty and stenting a subgroup analysis of the pro-CAS data. Stroke 39(8):2325–2330PubMedCrossRef Theiss W, Hermanek P, Mathias K et al (2008) Predictors of death and stroke after carotid angioplasty and stenting a subgroup analysis of the pro-CAS data. Stroke 39(8):2325–2330PubMedCrossRef
12.
Zurück zum Zitat Rothwell PM, Eliasziw M, Gutnikov SA, Fox AJ, Taylor DW, Mayberg MR, Warlow CP, Barnett HJM, Carotid Endarterectomy Trialists' Collaboration (2003) Analysis of pooled data from the randomized controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 361:107–116PubMedCrossRef Rothwell PM, Eliasziw M, Gutnikov SA, Fox AJ, Taylor DW, Mayberg MR, Warlow CP, Barnett HJM, Carotid Endarterectomy Trialists' Collaboration (2003) Analysis of pooled data from the randomized controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 361:107–116PubMedCrossRef
13.
Zurück zum Zitat Jordan WD Jr, Voellinger DC, Doblar DD, Plyushcheva NP, Fisher WS, McDowell HA (1999) Microemboli detected by transcranial doppler monitoring in patients during carotid angioplasty versus carotid endarterectomy. Cardiovasc Surg 7:33–38PubMedCrossRef Jordan WD Jr, Voellinger DC, Doblar DD, Plyushcheva NP, Fisher WS, McDowell HA (1999) Microemboli detected by transcranial doppler monitoring in patients during carotid angioplasty versus carotid endarterectomy. Cardiovasc Surg 7:33–38PubMedCrossRef
14.
Zurück zum Zitat Ohki T, Marin ML, Lyon RT (1998) Ex vivo human carotid artery bifurcation stenting: correlation of lesion characteristics with embolic potential. J Vasc Surg 27:463–471PubMedCrossRef Ohki T, Marin ML, Lyon RT (1998) Ex vivo human carotid artery bifurcation stenting: correlation of lesion characteristics with embolic potential. J Vasc Surg 27:463–471PubMedCrossRef
15.
Zurück zum Zitat Manninen HI, Rasanen HT, Vanninen RL, Vainio P, Hippel MM, Kosma V (1999) Stent placement versus percutaneous transluminal angioplasty of human carotid arteries in cadavers in situ: distal embolization and findings at intravascular US, MR imaging, and histopathologic analysis. Radiology 212:483–492PubMed Manninen HI, Rasanen HT, Vanninen RL, Vainio P, Hippel MM, Kosma V (1999) Stent placement versus percutaneous transluminal angioplasty of human carotid arteries in cadavers in situ: distal embolization and findings at intravascular US, MR imaging, and histopathologic analysis. Radiology 212:483–492PubMed
16.
Zurück zum Zitat Orlandi G, Fanucchi S, Fioretti C et al (2001) Characteristics of cerebral microembolism during carotid stenting and angioplasty alone. Arch Neurol 58(9):1410–1413PubMedCrossRef Orlandi G, Fanucchi S, Fioretti C et al (2001) Characteristics of cerebral microembolism during carotid stenting and angioplasty alone. Arch Neurol 58(9):1410–1413PubMedCrossRef
17.
Zurück zum Zitat Grunwald IQ, Papanagiotou P, Politi M et al (2006) Endovascular treatment of unruptured intracranial aneurysms: occurrence of thromboembolic events. Neurosurgery 58(4):612–618PubMedCrossRef Grunwald IQ, Papanagiotou P, Politi M et al (2006) Endovascular treatment of unruptured intracranial aneurysms: occurrence of thromboembolic events. Neurosurgery 58(4):612–618PubMedCrossRef
18.
Zurück zum Zitat Vos JA, van den Berg JC, Ernst SMPG, Suttorp MJ, Overtoom TTC, Mauser HW, Vogels OJM (2005) Carotid angioplasty and stent placement: comparison of transcranial Doppler US data and clinical outcome with and without filtering cerebral protection devices in 509 patients. Radiology 234:493–499PubMedCrossRef Vos JA, van den Berg JC, Ernst SMPG, Suttorp MJ, Overtoom TTC, Mauser HW, Vogels OJM (2005) Carotid angioplasty and stent placement: comparison of transcranial Doppler US data and clinical outcome with and without filtering cerebral protection devices in 509 patients. Radiology 234:493–499PubMedCrossRef
19.
Zurück zum Zitat Macdonald S, Evans DH, Griffiths PD, McKevitt FM, Venables GS, Cleveland TJ, Gaines PA (2010) Filter-protected versus unprotected carotid artery stenting: a randomised trial. Cerebrovasc Dis 29(3):282–289PubMedCrossRef Macdonald S, Evans DH, Griffiths PD, McKevitt FM, Venables GS, Cleveland TJ, Gaines PA (2010) Filter-protected versus unprotected carotid artery stenting: a randomised trial. Cerebrovasc Dis 29(3):282–289PubMedCrossRef
20.
Zurück zum Zitat Jaeger HJ, Mathias KD, Hauth E, Drescher R, Gissler HM, Hennigs S, Christmann A (2002) Cerebral ischemia detected with diffusion weighted MR imaging after stent implantation in the carotid artery. AJNR Am J Neuroradiol 23:200–207PubMed Jaeger HJ, Mathias KD, Hauth E, Drescher R, Gissler HM, Hennigs S, Christmann A (2002) Cerebral ischemia detected with diffusion weighted MR imaging after stent implantation in the carotid artery. AJNR Am J Neuroradiol 23:200–207PubMed
21.
Zurück zum Zitat Wholey MH, Wholey M, Mathias K et al (2000) Global experience in cervical carotid artery stenting. Cathet Cardiovasc Interv 50:160–167CrossRef Wholey MH, Wholey M, Mathias K et al (2000) Global experience in cervical carotid artery stenting. Cathet Cardiovasc Interv 50:160–167CrossRef
22.
Zurück zum Zitat Connors JJ III, Seidenwurm D, Wojak JC et al (2000) Treatment of atherosclerotic disease at the cervical carotid bifurcation: current status and review of literature. AJNR Am J Neuroradiol 21:444–450PubMed Connors JJ III, Seidenwurm D, Wojak JC et al (2000) Treatment of atherosclerotic disease at the cervical carotid bifurcation: current status and review of literature. AJNR Am J Neuroradiol 21:444–450PubMed
23.
Zurück zum Zitat Phatouros CC, Higashida RT, Malek AM et al (2000) Carotid artery stent placement for atherosclerotic disease: rationale, technique and current status. Radiology 217:26–41PubMed Phatouros CC, Higashida RT, Malek AM et al (2000) Carotid artery stent placement for atherosclerotic disease: rationale, technique and current status. Radiology 217:26–41PubMed
24.
Zurück zum Zitat Wholey MH, Jarmolowski CR, Wholey M, Eles GR (2003) Carotid artery stent placement: ready for prime time? J Vasc Interv Radiol 14:1–10PubMedCrossRef Wholey MH, Jarmolowski CR, Wholey M, Eles GR (2003) Carotid artery stent placement: ready for prime time? J Vasc Interv Radiol 14:1–10PubMedCrossRef
25.
Zurück zum Zitat Jaeger HJ, Mathias KD, Drescher R et al (2001) Diffusion weighted MR imaging after angioplasty or angioplasty plus stenting of arteries supplying the brain. AJNR Am J Neuroradiol 22(7):1251–1259PubMed Jaeger HJ, Mathias KD, Drescher R et al (2001) Diffusion weighted MR imaging after angioplasty or angioplasty plus stenting of arteries supplying the brain. AJNR Am J Neuroradiol 22(7):1251–1259PubMed
26.
Zurück zum Zitat Wholey MH, Al-Mubarek N (2003) Updated review of the global carotid artery stent registry. Cathet Cardiovasc Interv 60(2):259–266CrossRef Wholey MH, Al-Mubarek N (2003) Updated review of the global carotid artery stent registry. Cathet Cardiovasc Interv 60(2):259–266CrossRef
27.
Zurück zum Zitat Rapp JH, Wakil L, Sawhney R et al (2007) Subclinical embolization after carotid artery stenting: new lesions on diffusion-weighted magnetic resonance imaging occur postprocedure. J Vasc Surg 45(5):867–872PubMedCrossRef Rapp JH, Wakil L, Sawhney R et al (2007) Subclinical embolization after carotid artery stenting: new lesions on diffusion-weighted magnetic resonance imaging occur postprocedure. J Vasc Surg 45(5):867–872PubMedCrossRef
28.
Zurück zum Zitat Ringleb PA, Allenberg J, Bruckmann H et al (2006) 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non inferiority trial. Lancet 368(9543):1239–1247PubMedCrossRef Ringleb PA, Allenberg J, Bruckmann H et al (2006) 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non inferiority trial. Lancet 368(9543):1239–1247PubMedCrossRef
29.
Zurück zum Zitat Wholey MH, Wholey M (2003) Current status in cervical carotid artery stent placement. J Cardiovasc Surg (Torino) 44:331–339 Wholey MH, Wholey M (2003) Current status in cervical carotid artery stent placement. J Cardiovasc Surg (Torino) 44:331–339
30.
Zurück zum Zitat Hauth EAM, Drescher R, Christian Jansen H, Gissler M, Schwarz M, Forsting M, Jaeger HJ, Mathias KD (2006) Complications and follow-up after unprotected carotid artery stenting. Cardiovasc Intervent Radiol 29:511–518PubMedCrossRef Hauth EAM, Drescher R, Christian Jansen H, Gissler M, Schwarz M, Forsting M, Jaeger HJ, Mathias KD (2006) Complications and follow-up after unprotected carotid artery stenting. Cardiovasc Intervent Radiol 29:511–518PubMedCrossRef
31.
Zurück zum Zitat Fiehler J, Jansen O, Berger J, Eckstein HH, Ringleb PA, Stingele R (2008) Differences in complication rates among the centers in the SPACE study. Neuroradiology 50(12):1049–1053PubMedCrossRef Fiehler J, Jansen O, Berger J, Eckstein HH, Ringleb PA, Stingele R (2008) Differences in complication rates among the centers in the SPACE study. Neuroradiology 50(12):1049–1053PubMedCrossRef
Metadaten
Titel
Unprotected carotid artery stenting: complications in 6 months follow-up
verfasst von
Reza Mohammadian
Bahram Sohrabi
Reza Mansourizadeh
Farideh Mohammadian
Babak Nasiri
Sajad Haririan
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
Neuroradiology / Ausgabe 3/2012
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-011-0867-x

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