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30.10.2019 | Review Article

Update on management and progress of novel therapeutics for R/R AML: an Iberian expert panel consensus

verfasst von: Pau Montesinos, Juan Bergua, Joana Infante, Jordi Esteve, José Eduardo Guimaraes, Jordi Sierra, Miguel Ángel Sanz

Erschienen in: Annals of Hematology | Ausgabe 11/2019

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Abstract

A significant proportion of adult patients with acute myeloid leukemia (AML) fail to achieve complete remission or will relapse later on after achieving it. Prognosis for relapsed or refractory (R/R) AML patients remains discouraging, with the main curative option still relying on hematopoietic stem cell transplant (HSCT) for those who are eligible. Beyond morphological bone marrow and peripheral blood assessment, evaluation of patient performance status and comorbidities, as well as genetic/molecular characterization, is crucial to make an accurate diagnosis and prognosis, which will be useful to select the most appropriate treatment. Emerging strategies are mainly focusing on the development of immune- and molecular-based approaches. Novel targeted therapies are generally well tolerated, potentially allowing them to be administered alone or in combination with classical chemotherapy agents. Enrolment in clinical trials should be considered first option for R/R AML patients, either as a bridge to HSCT or to benefit from novel therapies that eventually may prolong survival and improve quality of life. An Iberian expert panel has reviewed the recent advances in the management of R/R AML with the aim to develop updated evidence and expert opinion-based recommendations.

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Titel: Update on management and progress of novel therapeutics for R/R AML: an Iberian expert panel consensus
verfasst von: Pau Montesinos
Juan Bergua
Joana Infante
Jordi Esteve
José Eduardo Guimaraes
Jordi Sierra
Miguel Ángel Sanz
Publikationsdatum: 30.10.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Annals of Hematology / Ausgabe 11/2019
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-019-03820-w

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