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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 9/2019

01.09.2019 | Autoimmunity (TK Tarrant, Section Editor)

Update on the Genetics of Autoinflammatory Disorders

verfasst von: Isabelle Jéru

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 9/2019

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Abstract

Purpose of the Review

This review aims at presenting the most significant data obtained in the field of the genetics of autoinflammatory disorders (AID) over the last past 5 years.

Recent Findings

More than 15 genes have been implicated in AID since 2014, unveiling new pathogenic pathways. Recent data have revealed atypical modes of transmission in several inherited AID, such as somatic mosaicism and digenism. First pieces of evidence showing an involvement of epigenetic modifications in the pathogenesis of AID have also been brought to light. Novel genetic data have been obtained on the molecular bases of genetically complex AID.

Summary

The development of next-generation sequencing in routine clinical practice has led to an explosion in the identification of new AID genes. Advances in the knowledge of AID further blur the limits between monogenic and multifactorial forms of these syndromes, and between autoinflammatory and autoimmune conditions.
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Metadaten
Titel
Update on the Genetics of Autoinflammatory Disorders
verfasst von
Isabelle Jéru
Publikationsdatum
01.09.2019
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 9/2019
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-019-0874-2

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