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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 9/2019

01.09.2019 | Autoimmunity (TK Tarrant, Section Editor)

Genetic and Environmental Contributors for Celiac Disease

verfasst von: Gloria Serena, Rosiane Lima, Alessio Fasano

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 9/2019

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Abstract

Purpose of Review

Celiac disease (CD) is an autoimmune enteropathy triggered by gluten. The purpose of this review is to examine the major genetic and environmental factors that contribute to CD pathogenesis.

Recent Findings

We reviewed the current state of knowledge on the genetic and environmental components that play a role in CD onset. A genome-wide association study (GWAS) analysis has highlighted several genes other than HLA involved in CD. Recent studies have shown that HLA haplotype influences the microbiome composition in infants and that dysbiosis in the intestinal microflora, in turn, contributes to loss of tolerance to gluten. Recently, observational studies have discussed the hypothesis stating that breast-feeding had a protective role against CD onset.

Summary

CD etiology is influenced by genetic and environmental factors. A better understanding of these components would deepen our knowledge on the mechanisms that lead to loss of tolerance and could help in developing a more “personalized medicine.”
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Metadaten
Titel
Genetic and Environmental Contributors for Celiac Disease
verfasst von
Gloria Serena
Rosiane Lima
Alessio Fasano
Publikationsdatum
01.09.2019
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 9/2019
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-019-0871-5

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Bilateraler Hörsturz hat eine schlechte Prognose

15.04.2024 Hörsturz Nachrichten

Die Mehrzahl der Menschen mit Hörsturz ist einseitig betroffen, doch auch ein beidseitiger Hörsturz ist möglich. Wie häufig solche Fälle sind und wie sich ihr Verlauf darstellt, hat eine HNO-Expertenrunde aus den USA untersucht.

Update HNO

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